Lung Cancer Screening

Semin Respir Crit Care Med. 2022 Dec;43(6):839-850. doi: 10.1055/s-0042-1757885. Epub 2022 Nov 28.

Abstract

Lung cancer is a leading cause of cancer death in the United States and globally with the majority of lung cancer cases attributable to cigarette smoking. Given the high societal and personal cost of a diagnosis of lung cancer including that most cases of lung cancer when diagnosed are found at a late stage, work over the past 40 years has aimed to detect lung cancer earlier when curative treatment is possible. Screening trials using chest radiography and sputum failed to show a reduction in lung cancer mortality however multiple studies using low dose CT have shown the ability to detect lung cancer early and a survival benefit to those screened. This review will discuss the history of lung cancer screening, current recommendations and screening guidelines, and implementation and components of a lung cancer screening program.

Publication types

  • Review

MeSH terms

  • Early Detection of Cancer*
  • Humans
  • Lung Neoplasms* / diagnostic imaging
  • Lung Neoplasms* / epidemiology
  • Sputum