1O17
 
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1IDJ
 | | PECTIN LYASE A | | Descriptor: | PECTIN LYASE A | | Authors: | Mayans, O, Scott, M, Connerton, I, Gravesen, T, Benen, J, Visser, J, Pickersgill, R, Jenkins, J. | | Deposit date: | 1996-10-04 | | Release date: | 1997-10-15 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Two crystal structures of pectin lyase A from Aspergillus reveal a pH driven conformational change and striking divergence in the substrate-binding clefts of pectin and pectate lyases.
Structure, 5, 1997
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1IDK
 | | PECTIN LYASE A | | Descriptor: | PECTIN LYASE A | | Authors: | Mayans, O, Scott, M, Connerton, I, Gravesen, T, Benen, J, Visser, J, Pickersgill, R, Jenkins, J. | | Deposit date: | 1996-10-04 | | Release date: | 1997-10-15 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.93 Å) | | Cite: | Two crystal structures of pectin lyase A from Aspergillus reveal a pH driven conformational change and striking divergence in the substrate-binding clefts of pectin and pectate lyases.
Structure, 5, 1997
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1GXB
 | | ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE IN COMPLEX WITH PYROPHOSPHATE AND MAGNESIUM | | Descriptor: | ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE, MAGNESIUM ION, PYROPHOSPHATE 2- | | Authors: | Mayans, O, Ivens, A, Nissen, L.J, Kirschner, K, Wilmanns, M. | | Deposit date: | 2002-04-02 | | Release date: | 2003-04-03 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | Structural Analysis of Two Enzymes Catalysing Reverse Metabolic Reactions Implies Common Ancestry
Embo J., 21, 2002
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1G1C
 | | I1 DOMAIN FROM TITIN | | Descriptor: | IMMUNOGLOBULIN-LIKE DOMAIN I1 FROM TITIN | | Authors: | Mayans, O, Wuerges, J, Gautel, M, Wilmanns, M. | | Deposit date: | 2000-10-11 | | Release date: | 2001-10-12 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural evidence for a possible role of reversible disulphide bridge formation in the elasticity of the muscle protein titin.
Structure, 9, 2001
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6FWX
 | | Chimeric titin Z1Z2-Z1Z2 tandem (Z1212) functionalized with a GRGDS exogenous peptide from fibronectin | | Descriptor: | 1,2-ETHANEDIOL, Titin,Titin,Titin | | Authors: | Mayans, O, Fleming, J, Hill, C. | | Deposit date: | 2018-03-07 | | Release date: | 2019-03-27 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Self-Assembling Proteins as High-Performance Substrates for Embryonic Stem Cell Self-Renewal.
Adv. Mater. Weinheim, 31, 2019
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3DDT
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6YP6
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4GSN
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8BVO
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8BXR
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8BW6
 | | Titin FnIII-domain I110 (I/A6) from the MIR region | | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Mayans, O, Fleming, J.R. | | Deposit date: | 2022-12-06 | | Release date: | 2023-02-15 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Immunological and Structural Characterization of Titin Main Immunogenic Region; I110 Domain Is the Target of Titin Antibodies in Myasthenia Gravis.
Biomedicines, 11, 2023
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4M3L
 | | Crystal Structure of the coiled coil domain of MuRF1 | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, E3 ubiquitin-protein ligase TRIM63, ... | | Authors: | Mayans, O, Franke, B. | | Deposit date: | 2013-08-06 | | Release date: | 2014-03-26 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Molecular basis for the fold organization and sarcomeric targeting of the muscle atrogin MuRF1.
Open Biol, 4, 2014
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4JNW
 | | Bacterially expressed Titin Kinase | | Descriptor: | GLYCEROL, Titin | | Authors: | Bogomolovas, J, Labeit, S, Mayans, O. | | Deposit date: | 2013-03-16 | | Release date: | 2014-05-14 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.06 Å) | | Cite: | Titin kinase is an inactive pseudokinase scaffold that supports MuRF1 recruitment to the sarcomeric M-line.
Open Biol, 4, 2014
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8OSP
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3UTO
 | | Twitchin kinase region from C.elegans (Fn31-NL-kin-CRD-Ig26) | | Descriptor: | 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, CITRATE ANION, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Castelmur, E, Barbieri, S, Mayans, O. | | Deposit date: | 2011-11-26 | | Release date: | 2012-08-08 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Identification of an N-terminal inhibitory extension as the primary mechanosensory regulator of twitchin kinase.
Proc.Natl.Acad.Sci.USA, 109, 2012
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4OAJ
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3LPW
 | | Crystal structure of the FnIII-tandem A77-A78 from the A-band of titin | | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, A77-A78 domain from Titin | | Authors: | Bucher, R.M, Mayans, O. | | Deposit date: | 2010-02-06 | | Release date: | 2010-09-08 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | The structure of the FnIII Tandem A77-A78 points to a periodically conserved architecture in the myosin-binding region of titin
J.Mol.Biol., 401, 2010
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8RYI
 | | Metformin hydrolase from Aminobacter niigataensis MD1 with urea in the active site | | Descriptor: | Agmatinase family protein, Arginase family protein, CALCIUM ION, ... | | Authors: | Fleming, J.R, Lutz, H, Bachmann, A, Mayans, O. | | Deposit date: | 2024-02-08 | | Release date: | 2024-08-28 | | Last modified: | 2024-10-02 | | Method: | X-RAY DIFFRACTION (2.06 Å) | | Cite: | Metformin hydrolase is a recently evolved nickel-dependent heteromeric ureohydrolase.
Nat Commun, 15, 2024
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1WT6
 | | Coiled-Coil domain of DMPK | | Descriptor: | Myotonin-protein kinase | | Authors: | Garcia, P, Marino, M, Mayans, O. | | Deposit date: | 2004-11-16 | | Release date: | 2005-11-16 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Molecular insights into the self-assembly mechanism of dystrophia myotonica kinase
Faseb J., 20, 2006
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3B43
 | | I-band fragment I65-I70 from titin | | Descriptor: | Titin | | Authors: | von Castelmur, E, Marino, M, Labeit, D, Labeit, S, Mayans, O. | | Deposit date: | 2007-10-23 | | Release date: | 2008-01-22 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | A regular pattern of Ig super-motifs defines segmental flexibility as the elastic mechanism of the titin chain
Proc.Natl.Acad.Sci.Usa, 105, 2008
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4YRU
 | | Crystal structure of C-terminally truncated Neuronal Calcium Sensor (NCS-1) from Rattus norvegicus | | Descriptor: | CALCIUM ION, Neuronal calcium sensor 1 | | Authors: | Pandalaneni, S, Karrupiah, V, Mayans, O, Derrick, J.P, Lian, L.Y. | | Deposit date: | 2015-03-15 | | Release date: | 2015-04-01 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Neuronal Calcium Sensor-1 Binds the D2 Dopamine Receptor and G-protein-coupled Receptor Kinase 1 (GRK1) Peptides Using Different Modes of Interactions.
J.Biol.Chem., 290, 2015
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7NIP
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2NZI
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5N2P
 | | Sulfolobus solfataricus Tryptophan Synthase A | | Descriptor: | CHLORIDE ION, TETRAETHYLENE GLYCOL, Tryptophan synthase alpha chain | | Authors: | Fleming, J, Mayans, O. | | Deposit date: | 2017-02-08 | | Release date: | 2018-06-13 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.059 Å) | | Cite: | Evolutionary Morphing of Tryptophan Synthase: Functional Mechanisms for the Enzymatic Channeling of Indole.
J.Mol.Biol., 430, 2018
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