1Y9J
 
 | | Solution structure of the rat Sly1 N-terminal domain | | Descriptor: | Sec1 family domain containing protein 1 | | Authors: | Arac, D, Dulubova, I, Pei, J, Huryeva, I, Grishin, N.V, Rizo, J. | | Deposit date: | 2004-12-15 | | Release date: | 2005-02-15 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Three-dimensional Structure of the rSly1 N-terminal Domain Reveals a Conformational Change Induced by Binding to Syntaxin 5.
J.Mol.Biol., 346, 2005
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4DLQ
 | | Crystal structure of the GAIN and HormR domains of CIRL 1/Latrophilin 1 (CL1) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... | | Authors: | Arac, D, Boucard, A.A, Bolliger, M.F, Nguyen, J, Soltis, M, Sudhof, T.C, Brunger, A.T. | | Deposit date: | 2012-02-06 | | Release date: | 2012-02-22 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis.
Embo J., 31, 2012
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4DLO
 | | Crystal structure of the GAIN and HormR domains of brain angiogenesis inhibitor 3 (BAI3) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Brain-specific angiogenesis inhibitor 3, ... | | Authors: | Arac, D, Boucard, A.A, Bolliger, M.F, Nguyen, J, Soltis, M, Sudhof, T.C, Brunger, A.T. | | Deposit date: | 2012-02-06 | | Release date: | 2012-02-22 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis.
Embo J., 31, 2012
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3BIX
 | | Crystal structure of the extracellular esterase domain of Neuroligin-1 | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, NICKEL (II) ION, ... | | Authors: | Arac, D, Boucard, A.A, Ozkan, E, Strop, P, Newell, E, Sudhof, T.C, Brunger, A.T. | | Deposit date: | 2007-12-01 | | Release date: | 2007-12-18 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structures of Neuroligin-1 and the Neuroligin-1/Neurexin-1beta Complex Reveal Specific Protein-Protein and Protein-Ca(2+) Interactions.
Neuron, 56, 2007
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3BIW
 | | Crystal structure of the Neuroligin-1/Neurexin-1beta synaptic adhesion complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Arac, D, Boucard, A.A, Ozkan, E, Strop, P, Newell, E, Sudhof, T.C, Brunger, A.T. | | Deposit date: | 2007-12-01 | | Release date: | 2007-12-18 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Structures of Neuroligin-1 and the Neuroligin-1/Neurexin-1beta Complex Reveal Specific Protein-Protein and Protein-Ca(2+) Interactions.
Neuron, 56, 2007
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5KVM
 | | Extracellular region of mouse GPR56/ADGRG1 in complex with FN3 monobody | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Adhesion G-protein coupled receptor G1, ... | | Authors: | Salzman, G.S, Ding, C, Koide, S, Arac, D. | | Deposit date: | 2016-07-14 | | Release date: | 2016-09-28 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.449 Å) | | Cite: | Structural Basis for Regulation of GPR56/ADGRG1 by Its Alternatively Spliced Extracellular Domains.
Neuron, 91, 2016
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8FIA
 | | The structure of fly Teneurin self assembly | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Bandekar, S.J, Li, J, Arac, D. | | Deposit date: | 2022-12-15 | | Release date: | 2023-05-03 | | Last modified: | 2023-06-14 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | The structure of fly Teneurin-m reveals an asymmetric self-assembly that allows expansion into zippers.
Embo Rep., 24, 2023
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8SUF
 | | The complex of TOL-1 ectodomain bound to LAT-1 Lectin domain | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Latrophilin-like protein 1, ... | | Authors: | Carmona Rosas, G, Li, J, Arac, D, Ozkan, E. | | Deposit date: | 2023-05-12 | | Release date: | 2024-05-15 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (4 Å) | | Cite: | Structural basis and functional roles for Toll-like receptor binding to Latrophilin adhesion-GPCR in embryo development
To Be Published
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8DJG
 | | ADGRL3-lectin domain in complex with an activating synthetic antibody fragment | | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Isoform 2 of Adhesion G protein-coupled receptor L3, ... | | Authors: | Kordon, S.P, Bandekar, S.J, Arac, D. | | Deposit date: | 2022-06-30 | | Release date: | 2023-02-15 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | Isoform- and ligand-specific modulation of the adhesion GPCR ADGRL3/Latrophilin3 by a synthetic binder.
Nat Commun, 14, 2023
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6V55
 | | Full extracellular region of zebrafish Gpr126/Adgrg6 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Adhesion G-protein coupled receptor G6, CALCIUM ION | | Authors: | Leon, K, Arac, D. | | Deposit date: | 2019-12-03 | | Release date: | 2020-01-15 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2.38 Å) | | Cite: | Structural basis for adhesion G protein-coupled receptor Gpr126 function.
Nat Commun, 11, 2020
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6VHH
 | | Human Teneurin-2 and human Latrophilin-3 binary complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Adhesion G protein-coupled receptor L3, ... | | Authors: | Xie, Y, Li, J, Arac, D, Zhao, M. | | Deposit date: | 2020-01-09 | | Release date: | 2020-06-03 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (2.97 Å) | | Cite: | Alternative splicing controls teneurin-latrophilin interaction and synapse specificity by a shape-shifting mechanism.
Nat Commun, 11, 2020
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6CMX
 | | Human Teneurin 2 extra-cellular region | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Teneurin-2, alpha-D-mannopyranose, ... | | Authors: | Shalev-Benami, M, Li, J, Sudhof, T, Skiniotis, G, Arac, D. | | Deposit date: | 2018-03-06 | | Release date: | 2018-07-25 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural Basis for Teneurin Function in Circuit-Wiring: A Toxin Motif at the Synapse.
Cell, 173, 2018
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1K5W
 | | THREE-DIMENSIONAL STRUCTURE OF THE SYNAPTOTAGMIN 1 C2B-DOMAIN: SYNAPTOTAGMIN 1 AS A PHOSPHOLIPID BINDING MACHINE | | Descriptor: | CALCIUM ION, Synaptotagmin I | | Authors: | Fernandez, I, Arac, D, Ubach, J, Gerber, S.H, Shin, O, Gao, Y, Anderson, R.G.W, Sudhof, T.C, Rizo, J. | | Deposit date: | 2001-10-12 | | Release date: | 2002-01-23 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Three-dimensional structure of the synaptotagmin 1 C2B-domain: synaptotagmin 1 as a phospholipid binding machine.
Neuron, 32, 2001
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5CMP
 | | human FLRT3 LRR domain | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Leucine-rich repeat transmembrane protein FLRT3 | | Authors: | Lu, Y, Salzman, G, Arac, D. | | Deposit date: | 2015-07-17 | | Release date: | 2015-08-12 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.601 Å) | | Cite: | Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion.
Structure, 23, 2015
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5CMN
 | | FLRT3 LRR domain in complex with LPHN3 Olfactomedin domain | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Latrophilin-3, ... | | Authors: | Lu, Y, Salzman, G, Arac, D. | | Deposit date: | 2015-07-17 | | Release date: | 2015-08-12 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (3.605 Å) | | Cite: | Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion.
Structure, 23, 2015
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1K8X
 | | Crystal Structure Of AlphaT183V Mutant Of Tryptophan Synthase From Salmonella Typhimurium | | Descriptor: | PYRIDOXAL-5'-PHOSPHATE, SODIUM ION, TRYPTOPHAN SYNTHASE, ... | | Authors: | Kulik, V, Weyand, M, Siedel, R, Niks, D, Arac, D, Dunn, M.F, Schlichting, I. | | Deposit date: | 2001-10-26 | | Release date: | 2002-12-18 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | On the Role of AlphaThr183 in the Allosteric Regulation and Catalytic Mechanism of Tryptophan Synthase
J.Mol.Biol., 324, 2002
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1KFJ
 | | CRYSTAL STRUCTURE OF WILD-TYPE TRYPTOPHAN SYNTHASE COMPLEXED WITH L-SERINE | | Descriptor: | SODIUM ION, TRYPTOPHAN SYNTHASE ALPHA CHAIN, TRYPTOPHAN SYNTHASE BETA CHAIN, ... | | Authors: | Kulik, V, Weyand, M, Seidel, R, Niks, D, Arac, D, Dunn, M.F, Schlichting, I. | | Deposit date: | 2001-11-21 | | Release date: | 2003-10-21 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | On the role of alphaThr183 in the allosteric regulation and catalytic mechanism of tryptophan synthase.
J.Mol.Biol., 324, 2002
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1KIL
 | | Three-dimensional structure of the complexin/SNARE complex | | Descriptor: | Complexin I SNARE-complex binding region, MAGNESIUM ION, SNAP-25 C-terminal SNARE motif, ... | | Authors: | Chen, X, Tomchick, D, Kovrigin, E, Arac, D, Machius, M, Sudhof, T.C, Rizo, J. | | Deposit date: | 2001-12-03 | | Release date: | 2002-03-13 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Three-dimensional structure of the complexin/SNARE complex.
Neuron, 33, 2002
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1KFK
 | | Crystal structure of Tryptophan Synthase From Salmonella Typhimurium | | Descriptor: | PYRIDOXAL-5'-PHOSPHATE, SODIUM ION, TRYPTOPHAN SYNTHASE ALPHA CHAIN, ... | | Authors: | Kulik, V, Weyand, M, Seidel, R, Niks, D, Arac, D, Dunn, M.F, Schlichting, I. | | Deposit date: | 2001-11-21 | | Release date: | 2003-10-21 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | On the role of alphaThr183 in the allosteric regulation and catalytic mechanism of tryptophan synthase.
J.Mol.Biol., 324, 2002
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1KFB
 | | CRYSTAL STRUCTURE OF ALPHAT183V MUTANT OF TRYPTOPHAN SYNTHASE FROM SALMONELLA TYPHIMURIUM WITH Indole Glycerol Phosphate | | Descriptor: | INDOLE-3-GLYCEROL PHOSPHATE, PYRIDOXAL-5'-PHOSPHATE, TRYPTOPHAN SYNTHASE ALPHA CHAIN, ... | | Authors: | Kulik, V, Weyand, M, Siedel, R, Niks, D, Arac, D, Dunn, M.F, Schlichting, I. | | Deposit date: | 2001-11-20 | | Release date: | 2003-01-07 | | Last modified: | 2021-10-27 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | On the Role of alphaTHR183 in the Allosteric Regulation and Catalytic Mechanism of Tryptophan Synthase
J.Mol.Biol., 324, 2002
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1KFE
 | | CRYSTAL STRUCTURE OF ALPHAT183V MUTANT OF TRYPTOPHAN SYNTHASE FROM SALMONELLA TYPHIMURIUM WITH L-Ser Bound To The Beta Site | | Descriptor: | SODIUM ION, TRYPTOPHAN SYNTHASE ALPHA CHAIN, TRYPTOPHAN SYNTHASE BETA CHAIN, ... | | Authors: | Kulik, V, Weyand, M, Siedel, R, Niks, D, Arac, D, Dunn, M.F, Schlichting, I. | | Deposit date: | 2001-11-20 | | Release date: | 2003-01-07 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | On the Role of AlphaTHR183 in the Allosteric Regulation and Catalytic Mechanism of Tryptophan Synthase
J.Mol.Biol., 324, 2002
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1KFC
 | | CRYSTAL STRUCTURE OF ALPHAT183V MUTANT OF TRYPTOPHAN SYNTHASE FROM SALMONELLA TYPHIMURIUM With Indole Propanol Phosphate | | Descriptor: | INDOLE-3-PROPANOL PHOSPHATE, PYRIDOXAL-5'-PHOSPHATE, SODIUM ION, ... | | Authors: | Kulik, V, Weyand, M, Siedel, R, Niks, D, Arac, D, Dunn, M.F, Schlichting, I. | | Deposit date: | 2001-11-20 | | Release date: | 2003-01-07 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | On the Role of AlphaTHR183 in the Allosteric Regulation and Catalytic Mechanism of Tryptophan Synthase
J.Mol.Biol., 324, 2002
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