Pharos : Ligand List

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Type

description

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Ligand

354150

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Drug

1782

Activity

description

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IC50

237397

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Ki

98714

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EC50

34816

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Kd

7573

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AC50

4722

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KB

22

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A2

9

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ED50

5

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ID50

2

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IC90

1

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MEC

1

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XC50

1

Action

description

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INHIBITOR

557

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AGONIST

428

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ANTAGONIST

338

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BLOCKER

124

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ANTIBODY BINDING

80

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POSITIVE ALLOSTERIC MODULATOR

41

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ACTIVATOR

32

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BINDING AGENT

28

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MODULATOR

23

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OPENER

15

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POSITIVE MODULATOR

14

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PARTIAL AGONIST

13

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ANTISENSE INHIBITOR

8

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INVERSE AGONIST

8

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SUBSTRATE

6

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GATING INHIBITOR

6

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RELEASING AGENT

5

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NEGATIVE ALLOSTERIC MODULATOR

4

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PHARMACOLOGICAL CHAPERONE

3

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ALLOSTERIC MODULATOR

3

Target Count

description

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1

21

[ 1, 21 ]

Data Source

description

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PubChem CIDs

355932

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ChEMBL

353872

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Guide to Pharmacology

5136

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Drug Central - ChEMBL

1095

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Drug Central - Scientific Literature

277

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Drug Central - Drug Label

200

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Drug Central - GtoPdb

156

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Drug Central - Kegg Drug

17

PANTHER Class

description

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receptor

84897

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G-protein coupled receptor

68127

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hydrolase

40137

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transferase

36775

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protease

28353

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nucleic acid binding

24785

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kinase

24667

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transporter

24433

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serine protease

23700

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oxidoreductase

23338

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protein kinase

21456

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non-receptor serine/threonine protein kinase

18942

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ion channel

14620

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transcription factor

13159

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C4 zinc finger nuclear receptor

10166

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oxygenase

9155

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protease inhibitor

8974

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aspartic protease

8761

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metalloprotease

8387

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reductase

8287

DTO Class

description

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G-protein coupled receptor

88674

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Class A rhodopsin like

82334

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Enzyme

77170

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Kinase

58811

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Protein kinase

55273

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Protease

44183

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Ion channel

29818

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TK group

25147

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Serine protease

19942

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Oxidoreductase

14876

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Transporter

12423

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Epigenetic regulator

11772

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Nuclear receptor

11718

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5-hydroxytryptamine receptor

10449

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SLC superfamily of solute carriers

10007

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Hydrolase

9382

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Oxygenase

9155

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Aspartic protease

8761

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Metalloprotease

8374

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Transferase

7768

Reactome Pathway

description

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Signal Transduction

189639

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Signaling by GPCR

116657

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GPCR downstream signalling

115578

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Immune System

103440

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GPCR ligand binding

90526

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Metabolism

86038

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Class A/1 (Rhodopsin-like receptors)

83856

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Cytokine Signaling in Immune system

68914

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Metabolism of proteins

66591

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Signaling by Interleukins

65852

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Disease

64567

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Gene expression (Transcription)

60538

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RNA Polymerase II Transcription

59349

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Generic Transcription Pathway

59278

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G alpha (i) signalling events

58802

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Innate Immune System

57000

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Hemostasis

54268

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Metabolism of lipids

49303

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G alpha (q) signalling events

45630

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Signaling by Receptor Tyrosine Kinases

44116

Ligands (355932)

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IDG

NIH Common Fund IDG KMC

PHAROS

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