Protein Summary
Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival. This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane pr ...more
- ENST00000319622
- ENSP00000320171
- ENSG00000067225
- ENST00000335181
- ENSP00000334983
- ENST00000449901
- ENSP00000403365
- ENST00000565154
- ENSP00000455901
- ENST00000565184
- ENSP00000455736
- ENST00000568459
- ENSP00000456970
- OIP3
- PK2
- PK3
- PKM2
- PK3
- TCB
- OIP3
- PKM2
- CTHBP
- THBP1
- HEL-S-30
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 1 | ||
viral protein | 1 | ||
virus | 1 | ||
molecular function | 0.99 | ||
protein complex | 0.98 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1905.09 (req: < 5)
Gene RIFs: 444 (req: <= 3)
Antibodies: 1066 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1905.09 (req: >= 5)
Gene RIFs: 444 (req: > 3)
Antibodies: 1066 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 25
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 16
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1