CCR2
C-C chemokine receptor type 2
Protein Summary
Receptor for the CCL2, CCL7 and CCL13 chemokines (PubMed:23408426). Receptor for the beta-defensin DEFB106A/DEFB106B (PubMed:23938203). Transduces a signal by increasing intracellular calcium ion levels (By similarity). Upon CCL2 ligation, mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion (Probable). (Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection. The protein encoded by this gene is a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The encoded protein mediates agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This protein can also be a coreceptor with CD4 for HIV-1 infection. This gene is located in the ch ...more
- ENST00000292301
- ENSP00000292301
- ENSG00000121807
- ENST00000400888
- ENSP00000383681
- ENST00000445132
- ENSP00000399285
- CMKBR2
- CKR2
- CCR-2
- CCR2A
- CCR2B
- CD192
- CKR2A
- CKR2B
- CMKBR2
- MCP-1-R
- CC-CKR-2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
ligand (protein) | 1 | ||
gene perturbation | 0.92 | ||
molecular function | 0.81 | ||
cellular component | 0.78 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1762.59 (req: < 5)
Gene RIFs: 327 (req: <= 3)
Antibodies: 800 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1762.59 (req: >= 5)
Gene RIFs: 327 (req: > 3)
Antibodies: 800 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 55
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 984
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1