PIK3CD
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
Protein Summary
Phosphoinositide-3-kinase (PI3K) that phosphorylates PftdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Mediates immune responses. Plays a role in B-cell development, proliferation, migration, and function. Required for B-cell receptor (BCR) signaling. Mediates B-cell proliferation response to anti-IgM, anti-CD40 and IL4 stimulation. Promotes cytokine production in response to TLR4 and TLR9. Required for antibody class switch mediated by TLR9. Involved in the antigen presentation function of B-cells. Involved in B-cell chemotaxis in response to CXCL13 and sphingosine 1-phosphate (S1P). Required for proliferation, signaling and cytokine production of naive, effector and memory T-cells. Required for T-cell recepto ...more
- ENST00000377346
- ENSP00000366563
- ENSG00000171608
- APDS
- PI3K
- IMD14
- p110D
- P110DELTA
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
biological process | 0.97 | ||
molecular function | 0.96 | ||
pathway | 0.91 | ||
hub protein | 0.88 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 202.19 (req: < 5)
Gene RIFs: 134 (req: <= 3)
Antibodies: 517 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 202.19 (req: >= 5)
Gene RIFs: 134 (req: > 3)
Antibodies: 517 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 43
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 1408
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 5