Skip to main content
PMC home page
Gut logoLink to Gut
. 1988 Oct;29(10):1358–1363. doi: 10.1136/gut.29.10.1358

Gastrin cell function in familial multiple endocrine neoplasia type I.

C B Lamers 1, J I Rotter 1, J B Jansen 1
PMCID: PMC1434020  PMID: 2904393

Abstract

Recent studies have suggested that patients with multiple endocrine neoplasia type I (MEN I) may have abnormal serum gastrin secretion in the absence of gastrin producing tumours. G-(gastrin) cell function by three provocation tests in 20 patients with hyperparathyroidism from six MEN I-families were studied: each patient was an obligate carrier of the MEN I-gene. The serum gastrin response to secretin was used to identify the presence of gastrinoma, that to a test meal of G-cell hyperfunction of the antral and/or duodenal mucosa, and that to bombesin to differentiate antral from duodenal G-cell hyperfunction. Seven patients had basal hypergastrinaemia and hyperchlorhydria. These patients had increased serum gastrin responses to secretin (p less than 0.01) and to bombesin (p less than 0.02), but normal postprandial responses. In the 13 normogastrinaemic patients the responses to the three stimuli were normal. In families with MEN-I gastrinoma is the only endocrine disorder accounting for abnormal gastrin secretion. G-cell function is normal in obligate carriers of the MEN I-gene.

Full text

PDF
1358

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barreras R. F. Calcium and gastric secretion. Gastroenterology. 1973 Jun;64(6):1168–1184. [PubMed] [Google Scholar]
  2. Basso N., Lezoche E., Materia A., Giri S., Speranza V. Effect of bombesin on extragastric gastrin in man. Am J Dig Dis. 1975 Oct;20(10):923–927. doi: 10.1007/BF01070877. [DOI] [PubMed] [Google Scholar]
  3. Christiansen J. Primary hyperparathyroidism and peptic ulcer disease. Scand J Gastroenterol. 1974;9(2):111–114. [PubMed] [Google Scholar]
  4. Creutzfeldt W., Arnold R., Creutzfeldt C., Feurle G., Ketterer H. Gastrin and G-cells in the antral mucosa of patients with pernicious anaemia, acromegaly and hyperparathyroidism and in a Zollinger-Ellison tumour of the pancreas. Eur J Clin Invest. 1971 Sep;1(6):461–479. doi: 10.1111/j.1365-2362.1971.tb00558.x. [DOI] [PubMed] [Google Scholar]
  5. Dent R. I., James J. H., Want C. A., Deftos L. J., Talamo R., Fischer J. E. Hyperparathyroidism: gastric acid secretion and gastrin. Ann Surg. 1972 Sep;176(3):360–369. doi: 10.1097/00000658-197209000-00012. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Deveney C. W., Deveney K. E. Zollinger-Ellison syndrome (gastrinoma). Current diagnosis and treatment. Surg Clin North Am. 1987 Apr;67(2):411–422. doi: 10.1016/s0039-6109(16)44192-7. [DOI] [PubMed] [Google Scholar]
  7. Friesen S. R., Schimke R. N., Pearse A. G. Genetic aspects of the Z-E syndrome: prospective studies in two kindred; antral gastrin cell hyperplasia. Ann Surg. 1972 Sep;176(3):370–383. doi: 10.1097/00000658-197209000-00013. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Friesen S. R. The development of endocrinopathies in the prospective screening of two families with multiple endocrine adenopathy, type I. World J Surg. 1979 Nov;3(6):753–764. doi: 10.1007/BF01654811. [DOI] [PubMed] [Google Scholar]
  9. Isenberg J. I., Walsh J. H., Grossman M. I. Zollinger-Ellison syndrome. Gastroenterology. 1973 Jul;65(1):140–165. [PubMed] [Google Scholar]
  10. Isenberg J. I., Walsh J. H., Passaro E., Jr, Moore E. W., Grossman M. I. Unusual effect of secretin on serum gastrin, serum calcium, and gastric acid secretion in a patient with suspected Zollinger-Ellison syndrome. Gastroenterology. 1972 Apr;62(4):626–631. [PubMed] [Google Scholar]
  11. Jansen J. B., Lamers C. B. Serum gastrin responses to bombesin and food in patients with hypergastrinemia. Dig Dis Sci. 1982 Apr;27(4):303–307. doi: 10.1007/BF01296748. [DOI] [PubMed] [Google Scholar]
  12. Lambers C. B., Lind T., Moberg S., Jansen J. B., Olbe L. Omeprazole in Zollinger-Ellison syndrome. Effects of a single dose and of long-term treatment in patients resistant to histamine H2-receptor antagonists. N Engl J Med. 1984 Mar 22;310(12):758–761. doi: 10.1056/NEJM198403223101205. [DOI] [PubMed] [Google Scholar]
  13. Lamers C. B., Buis J. T., van Tongeren J. Secretin-stimulated serum gastrin levels in hyperparathyroid patients from families with multiple endocrine adenomatosis type I. Ann Intern Med. 1977 Jun;86(6):719–724. doi: 10.7326/0003-4819-86-6-719. [DOI] [PubMed] [Google Scholar]
  14. Lamers C. B. Clinical usefulness of the secretin provocation test. J Clin Gastroenterol. 1981 Sep;3(3):255–259. doi: 10.1097/00004836-198109000-00009. [DOI] [PubMed] [Google Scholar]
  15. Lamers C. B. Familial multiple endocrine neoplasia type I (Wermer's syndrome). Neth J Med. 1978;21(6):270–274. [PubMed] [Google Scholar]
  16. Lamers C. B., Ruland C. M., Joosten H. J., Verkooyen H. C., van Tongeren J. H., Rehfeld J. F. Hypergastrinemia of antral origin in duodenal ulcer. Am J Dig Dis. 1978 Nov;23(11):998–1002. doi: 10.1007/BF01263099. [DOI] [PubMed] [Google Scholar]
  17. Lamers C. B., Stadil F., Van Tongeren J. H. Prevalence of endocrine abnormalities in patients with the Zollinger-Ellison syndrome and in their families. Am J Med. 1978 Apr;64(4):607–612. doi: 10.1016/0002-9343(78)90580-6. [DOI] [PubMed] [Google Scholar]
  18. Lamers C. B., Van Tongeren J. H. Serum gastrin response to acute and chronic hypercalcaemia in man: studies on the value of calcium stimulated serum gastrin levels in the diagnosis of Zollinger-Ellison syndrome. Eur J Clin Invest. 1977 Aug;7(4):315–317. doi: 10.1111/j.1365-2362.1977.tb01611.x. [DOI] [PubMed] [Google Scholar]
  19. Lips C. J., Vasen H. F., Lamers C. B. Multiple endocrine neoplasia syndromes. Crit Rev Oncol Hematol. 1984;2(2):117–184. doi: 10.1016/s1040-8428(84)80017-7. [DOI] [PubMed] [Google Scholar]
  20. Norton J. A., Cornelius M. J., Doppman J. L., Maton P. N., Gardner J. D., Jensen R. T. Effect of parathyroidectomy in patients with hyperparathyroidism, Zollinger-Ellison syndrome, and multiple endocrine neoplasia type I: a prospective study. Surgery. 1987 Dec;102(6):958–966. [PubMed] [Google Scholar]
  21. Passaro E., Jr, Stabile B. E. Of gastrinomas and their management. Gastroenterology. 1983 Jun;84(6):1621–1623. [PubMed] [Google Scholar]
  22. Skogseid B., Oberg K., Benson L., Lindgren P. G., Lörelius L. E., Lundquist G., Wide L., Wilander E. A standardized meal stimulation test of the endocrine pancreas for early detection of pancreatic endocrine tumors in multiple endocrine neoplasia type 1 syndrome: five years experience. J Clin Endocrinol Metab. 1987 Jun;64(6):1233–1240. doi: 10.1210/jcem-64-6-1233. [DOI] [PubMed] [Google Scholar]
  23. Strodel W. E., Vinik A. I., Eckhauser F. E., Thompson N. W. Hyperparathyroidism and gastroenteropancreatic hormone levels. Surgery. 1985 Dec;98(6):1101–1106. [PubMed] [Google Scholar]
  24. Taylor I. L., Calam J., Rotter J. I., Vaillant C., Samloff I. M., Cook A., Simkin E., Dockray G. J. Family studies of hypergastrinemic, hyperpepsinogenemic I duodenal ulcer. Ann Intern Med. 1981 Oct;95(4):421–425. doi: 10.7326/0003-4819-95-4-421. [DOI] [PubMed] [Google Scholar]
  25. WERMER P. Genetic aspects of adenomatosis of endocrine glands. Am J Med. 1954 Mar;16(3):363–371. doi: 10.1016/0002-9343(54)90353-8. [DOI] [PubMed] [Google Scholar]
  26. Zaniewski M., Jordan P. H., Jr, Yip B., Thornby J. I., Mallette L. E. Serum gastrin level is increased by chronic hypercalcemia of parathyroid or nonparathyroid origin. Arch Intern Med. 1986 Mar;146(3):478–482. [PubMed] [Google Scholar]
  27. van Heerden J. A., Smith S. L., Miller L. J. Management of the Zollinger-Ellison syndrome in patients with multiple endocrine neoplasia type I. Surgery. 1986 Dec;100(6):971–977. [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES