SB-215505

SB-215505 é uma droga que actua como antagonista potente e selectivo no receptor de serotonina 5-HT_2B, com uma boa selectividade sobre os relacionados receptores 5-HT_2A e 5-HT_2C.^[1]

É usada em pesquisa científica relacionada com a função da família de receptores 5-HT₂, especialmente para estudar o papeldos receptores 5-HT_2B no coração,^[2]^[3]^[4] e para distinguir as respostas mediadas por 5-HT_2B das produzidas por 5-HT_2A ou 5-HT_2C.^[5]^[6]^[7]

Referências

↑ Kantor S, Jakus R, Balogh B, Benko A, Bagdy G (2004). «Increased wakefulness, motor activity and decreased theta activity after blockade of the 5-HT2B receptor by the subtype-selective antagonist SB-215505». British Journal of Pharmacology. 142 (8): 1332–42. PMC 1575194. PMID 15265808. doi:10.1038/sj.bjp.0705887
↑ Jaffré F, Callebert J, Sarre A, Etienne N, Nebigil CG, Launay JM, Maroteaux L, Monassier L (2004). «Involvement of the serotonin 5-HT2B receptor in cardiac hypertrophy linked to sympathetic stimulation: control of interleukin-6, interleukin-1beta, and tumor necrosis factor-alpha cytokine production by ventricular fibroblasts». Circulation. 110 (8): 969–74. PMID 15302781. doi:10.1161/01.CIR.0000139856.20505.57
↑ Liang YJ, Lai LP, Wang BW, Juang SJ, Chang CM, Leu JG, Shyu KG (2006). «Mechanical stress enhances serotonin 2B receptor modulating brain natriuretic peptide through nuclear factor-kappaB in cardiomyocytes». Cardiovascular Research. 72 (2): 303–12. PMID 16962085. doi:10.1016/j.cardiores.2006.08.003
↑ Monassier L, Laplante MA, Jaffré F, Bousquet P, Maroteaux L, de Champlain J (2008). «Serotonin 5-HT(2B) receptor blockade prevents reactive oxygen species-induced cardiac hypertrophy in mice». Hypertension. 52 (2): 301–7. PMID 18591460. doi:10.1161/HYPERTENSIONAHA.107.105551
↑ Reavill C, Kettle A, Holland V, Riley G, Blackburn TP (1999). «Attenuation of haloperidol-induced catalepsy by a 5-HT2C receptor antagonist». British Journal of Pharmacology. 126 (3): 572–4. PMC 1565856. PMID 10188965. doi:10.1038/sj.bjp.0702350
↑ Fletcher PJ, Grottick AJ, Higgins GA (2002). «Differential effects of the 5-HT(2A) receptor antagonist M100907 and the 5-HT(2C) receptor antagonist SB242084 on cocaine-induced locomotor activity, cocaine self-administration and cocaine-induced reinstatement of responding». Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 27 (4): 576–86. PMID 12377394. doi:10.1016/S0893-133X(02)00342-1
↑ Fletcher PJ, Tampakeras M, Sinyard J, Higgins GA (2007). «Opposing effects of 5-HT(2A) and 5-HT(2C) receptor antagonists in the rat and mouse on premature responding in the five-choice serial reaction time test». Psychopharmacology. 195 (2): 223–34. PMID 17673981. doi:10.1007/s00213-007-0891-z

[pmid15265808-1] Kantor S, Jakus R, Balogh B, Benko A, Bagdy G (2004). «Increased wakefulness, motor activity and decreased theta activity after blockade of the 5-HT2B receptor by the subtype-selective antagonist SB-215505». British Journal of Pharmacology. 142 (8): 1332–42. PMC 1575194. PMID 15265808. doi:10.1038/sj.bjp.0705887

[pmid15302781-2] Jaffré F, Callebert J, Sarre A, Etienne N, Nebigil CG, Launay JM, Maroteaux L, Monassier L (2004). «Involvement of the serotonin 5-HT2B receptor in cardiac hypertrophy linked to sympathetic stimulation: control of interleukin-6, interleukin-1beta, and tumor necrosis factor-alpha cytokine production by ventricular fibroblasts». Circulation. 110 (8): 969–74. PMID 15302781. doi:10.1161/01.CIR.0000139856.20505.57

[pmid16962085-3] Liang YJ, Lai LP, Wang BW, Juang SJ, Chang CM, Leu JG, Shyu KG (2006). «Mechanical stress enhances serotonin 2B receptor modulating brain natriuretic peptide through nuclear factor-kappaB in cardiomyocytes». Cardiovascular Research. 72 (2): 303–12. PMID 16962085. doi:10.1016/j.cardiores.2006.08.003

[pmid18591460-4] Monassier L, Laplante MA, Jaffré F, Bousquet P, Maroteaux L, de Champlain J (2008). «Serotonin 5-HT(2B) receptor blockade prevents reactive oxygen species-induced cardiac hypertrophy in mice». Hypertension. 52 (2): 301–7. PMID 18591460. doi:10.1161/HYPERTENSIONAHA.107.105551

[pmid10188965-5] Reavill C, Kettle A, Holland V, Riley G, Blackburn TP (1999). «Attenuation of haloperidol-induced catalepsy by a 5-HT2C receptor antagonist». British Journal of Pharmacology. 126 (3): 572–4. PMC 1565856. PMID 10188965. doi:10.1038/sj.bjp.0702350

[pmid12377394-6] Fletcher PJ, Grottick AJ, Higgins GA (2002). «Differential effects of the 5-HT(2A) receptor antagonist M100907 and the 5-HT(2C) receptor antagonist SB242084 on cocaine-induced locomotor activity, cocaine self-administration and cocaine-induced reinstatement of responding». Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 27 (4): 576–86. PMID 12377394. doi:10.1016/S0893-133X(02)00342-1

[pmid17673981-7] Fletcher PJ, Tampakeras M, Sinyard J, Higgins GA (2007). «Opposing effects of 5-HT(2A) and 5-HT(2C) receptor antagonists in the rat and mouse on premature responding in the five-choice serial reaction time test». Psychopharmacology. 195 (2): 223–34. PMID 17673981. doi:10.1007/s00213-007-0891-z

[1]

[2]

[3]

[4]

[5]

[6]

[7]