Inhibition of human immunodeficiency virus type 1 replication in primary CD4(+) T lymphocytes, monocytes, and dendritic cells by cytotoxic T lymphocytes

M E Severino; N V Sipsas; P T Nguyen; S A Kalams; B D Walker; R P Johnson; O O Yang

doi:10.1128/jvi.74.14.6695-6699.2000

Inhibition of human immunodeficiency virus type 1 replication in primary CD4(+) T lymphocytes, monocytes, and dendritic cells by cytotoxic T lymphocytes

J Virol. 2000 Jul;74(14):6695-9. doi: 10.1128/jvi.74.14.6695-6699.2000.

Authors

M E Severino¹, N V Sipsas, P T Nguyen, S A Kalams, B D Walker, R P Johnson, O O Yang

Affiliation

¹ AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA.

Abstract

We demonstrate that human immunodeficiency virus type 1 (HIV-1)-specific CD8(+) cytotoxic T lymphocytes (CTL) suppress HIV-1 replication in primary lymphocytes, monocytes, and dendritic cells individually. Viral inhibition is significantly diminished in lymphocyte-dendritic cell clusters, suggesting that these clusters in vivo could be sites where viral replication is more difficult to control by CTL.

Publication types

Research Support, U.S. Gov't, P.H.S.

MeSH terms

CD4-Positive T-Lymphocytes / immunology*
CD4-Positive T-Lymphocytes / virology
Cells, Cultured
Cytotoxicity, Immunologic
Dendritic Cells / immunology*
Dendritic Cells / virology
HIV-1 / immunology*
HIV-1 / physiology
Humans
Monocytes / immunology*
Monocytes / virology
T-Lymphocytes, Cytotoxic / immunology*
T-Lymphocytes, Cytotoxic / virology
Virus Replication

Abstract

Publication types

MeSH terms

Grants and funding