Cooperative ratiometric chemosensors: pinwheel receptors with an integrated fluorescence system

J Org Chem. 2001 Oct 5;66(20):6505-12. doi: 10.1021/jo001775t.

Abstract

The synthesis and fluorescent properties of a second generation cooperative chemical sensor are described. The sensor has two interacting binding pockets for cooperative recognition of two analytes. Cooperative binding activates a ratiometric fluorescent response via formation of an excimer. Binding was characterized by NMR, absorption, and fluorescence spectroscopy. The advantages of separating the recognition elements from the fluorescent response elements are discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acetylene / analogs & derivatives
  • Binding Sites
  • Biosensing Techniques*
  • Fluorescent Dyes / chemical synthesis
  • Polycyclic Aromatic Hydrocarbons / chemistry
  • Spectrum Analysis

Substances

  • Fluorescent Dyes
  • Polycyclic Aromatic Hydrocarbons
  • Acetylene