Abstract
Four of six specific pathogen-free cats were infected after intravaginal exposure to molecularly cloned lymphotropic but non-Crandell feline kidney (CRFK)-tropic feline immunodeficiency virus strain TM2 and its AP-1 deletion mutant. The sequences of the env V3-to-V5 region which defines the CRFK tropism were unchanged in the infected cats through the infection. These data suggest that the strain was transmitted across the mucosal epithelium without a broadening of cell tropism.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Antibodies, Viral / blood
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Cats
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Cloning, Molecular
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Disease Models, Animal
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Feline Acquired Immunodeficiency Syndrome / transmission*
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Feline Acquired Immunodeficiency Syndrome / virology
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Female
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Immunodeficiency Virus, Feline / genetics*
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Immunodeficiency Virus, Feline / immunology
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Lentivirus Infections / transmission
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Lentivirus Infections / virology
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Molecular Sequence Data
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Mucous Membrane / virology*
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Mutation*
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Tropism
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Vagina / virology