Endophytic naphthopyrone metabolites are co-inhibitors of xanthine oxidase, SW1116 cell and some microbial growths

Y C Song; H Li; Y H Ye; C Y Shan; Y M Yang; R X Tan

doi:10.1016/j.femsle.2004.10.005

Endophytic naphthopyrone metabolites are co-inhibitors of xanthine oxidase, SW1116 cell and some microbial growths

FEMS Microbiol Lett. 2004 Dec 1;241(1):67-72. doi: 10.1016/j.femsle.2004.10.005.

Authors

Y C Song¹, H Li, Y H Ye, C Y Shan, Y M Yang, R X Tan

Affiliation

¹ Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, PR China.

PMID: 15556711
DOI: 10.1016/j.femsle.2004.10.005

Abstract

Fractionation of the extract of Aspergillus niger. IFB-E003, an endophyte in Cyndon dactylon, gave four known compounds naphtho-gamma-pyrones rubrofusarin B, fonsecinone A, asperpyrone B and aurasperone A, which were further investigated biologically. Rubrofusarin B was shown to be cytotoxic to the colon cancer cell line SW1116 (IC50: 4.5 microgml-1), and aurasperone A inhibitory on XO (xanthine oxidase) (IC50: 10.9 micromoll-1). Moreover, the four naphtho-gamma-pyrones exhibited growth inhibitions against the five test microbes with MICs ranging in between 1.9 and 31.2 microgml(-1). The present recognition of rubrofusarin B and aurasperone A as strong co-inhibitors on XO, colon cancer cell and some microbial pathogens is of significance for the imperative discovery of new relevant therapeutic agents.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Infective Agents / pharmacology*
Aspergillus niger / metabolism*
Enzyme Inhibitors / pharmacology*
Pyrones / pharmacology*
Xanthine Oxidase / antagonists & inhibitors*

Substances

Anti-Infective Agents
Enzyme Inhibitors
Pyrones
rubrofusarin
Xanthine Oxidase