Neural network modeling and control of type 1 diabetes mellitus

Bioprocess Biosyst Eng. 2005 Apr;27(2):75-9. doi: 10.1007/s00449-004-0363-3. Epub 2004 Dec 1.

Abstract

This paper presents a developed and validated dynamic simulation model of type 1 diabetes, that simulates the progression of the disease and the two term controller that is responsible for the insulin released to stabilize the glucose level. The modeling and simulation of type 1 diabetes mellitus is based on an artificial neural network approach. The methodology builds upon an existing rich database on the progression of type 1 diabetes for a group of diabetic patients. The model was found to perform well at estimating the next glucose level over time without control. A neural controller that mimics the pancreas secretion of insulin into the body was also developed. This controller is of the two term type: one stage is responsible for short-term and the other for mid-term insulin delivery. It was found that the controller designed predicts an adequate amount of insulin that should be delivered into the body to obtain a normalization of the elevated glucose level. This helps to achieve the main objective of insulin therapy: to obtain an accurate estimate of the amount of insulin to be delivered in order to compensate for the increase in glucose concentration.

Publication types

  • Evaluation Study

MeSH terms

  • Algorithms
  • Blood Glucose / analysis*
  • Computer Simulation
  • Diabetes Mellitus, Type 1 / drug therapy*
  • Diabetes Mellitus, Type 1 / physiopathology*
  • Drug Therapy, Computer-Assisted / methods*
  • Feedback
  • Humans
  • Insulin / administration & dosage*
  • Insulin Infusion Systems
  • Metabolic Clearance Rate
  • Models, Biological*
  • Neural Networks, Computer*
  • Treatment Outcome

Substances

  • Blood Glucose
  • Insulin