Abstract
Human aging is characterized by debilitating diseases, including heart failure, cardiac pacemaker defects, muscle wasting, and osteoporosis, in heart, skeletal muscle, and bone. Recent studies are identifying pathways for these aging-related diseases by examining how the process of aging influences tissue-specific progenitors and differentiated cell lineages in these organ systems. These advances form a foundation for new therapeutic strategies to delay the onset of aging-related disorders.
MeSH terms
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Bone Diseases, Metabolic / genetics
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Bone Diseases, Metabolic / pathology
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Bone Diseases, Metabolic / physiopathology*
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Bone Remodeling / genetics
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Bone Remodeling / physiology
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Cell Differentiation / genetics
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Cell Differentiation / physiology
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Cell Lineage / genetics
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Cell Lineage / physiology*
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DNA, Mitochondrial / genetics
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DNA, Mitochondrial / physiology
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Heart Diseases / genetics
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Heart Diseases / pathology
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Heart Diseases / physiopathology*
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Humans
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Insulin-Like Growth Factor I / genetics
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Insulin-Like Growth Factor I / metabolism
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Longevity / genetics
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Longevity / physiology*
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Muscular Diseases / genetics
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Muscular Diseases / pathology
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Muscular Diseases / physiopathology*
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Mutation / genetics
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Mutation / physiology
Substances
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DNA, Mitochondrial
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Insulin-Like Growth Factor I