Abstract
Background:
Single nucleotide polymorphisms (SNPs) may show clinicopathological importance as prognostic markers. This study examined the association of SNPs and the expression of drug resistance-associated markers with response to chemotherapy in advanced ovarian cancer (stages III and IV) patients.
Materials and methods:
SNPs were analyzed for MDR1, MRP1, MRP2 and LRP in 60 advanced ovarian cancer patients. The protein expression of each factor was analyzed by immunohistochemistry in all patients.
Results:
As a result of examining the relevance of SNP genotypes to the response to chemotherapy, a significant relevance (p=0.01) was observed regarding MRP1 exon-17 SNP (G2168A) involving amino acid substitution. No significant relationship was observed between protein expression and the response to chemotherapy or disease-free survival time.
Conclusion:
Analysis of drug resistance gene polymorphism appears to be an indicator of the response to chemotherapy in advanced ovarian cancer.
MeSH terms
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ATP Binding Cassette Transporter, Subfamily B / biosynthesis
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ATP Binding Cassette Transporter, Subfamily B / genetics
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ATP Binding Cassette Transporter, Subfamily B, Member 1 / biosynthesis
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ATP Binding Cassette Transporter, Subfamily B, Member 1 / genetics
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ATP-Binding Cassette Sub-Family B Member 4
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Bridged-Ring Compounds / administration & dosage
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Carcinoma, Endometrioid / drug therapy
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Carcinoma, Endometrioid / genetics
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Carcinoma, Endometrioid / metabolism
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Carcinoma, Endometrioid / pathology
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Cystadenocarcinoma, Serous / drug therapy
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Cystadenocarcinoma, Serous / genetics
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Cystadenocarcinoma, Serous / metabolism
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Cystadenocarcinoma, Serous / pathology
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Drug Resistance, Multiple / genetics*
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Drug Resistance, Neoplasm
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Exons
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Female
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Humans
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Immunohistochemistry
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Multidrug Resistance-Associated Proteins / biosynthesis
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Multidrug Resistance-Associated Proteins / genetics*
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Neoplasm Proteins / biosynthesis
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Neoplasm Proteins / genetics
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Neoplasm Staging
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Organoplatinum Compounds / administration & dosage
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Ovarian Neoplasms / drug therapy*
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Ovarian Neoplasms / genetics*
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Ovarian Neoplasms / metabolism
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Ovarian Neoplasms / pathology
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Polymorphism, Single Nucleotide
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Prognosis
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Promoter Regions, Genetic
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Taxoids / administration & dosage
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Vault Ribonucleoprotein Particles / biosynthesis
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Vault Ribonucleoprotein Particles / genetics
Substances
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ATP Binding Cassette Transporter, Subfamily B
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ATP Binding Cassette Transporter, Subfamily B, Member 1
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Bridged-Ring Compounds
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Multidrug Resistance-Associated Proteins
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Neoplasm Proteins
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Organoplatinum Compounds
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Taxoids
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Vault Ribonucleoprotein Particles
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major vault protein
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taxane
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multidrug resistance-associated protein 1