Abstract
The adenosine triphosphate-binding cassette transporter-homologous gene ATP11A belongs to an extended family of adenosine triphosphate-binding cassette transporters. We analysed the ATP11A gene in 7 colorectal cancer cell lines and 95 paired cases of colorectal cancer and non-cancerous regions to demonstrate the importance of ATP11A expression in colorectal cancer prognosis. ATP11A was expressed in the 7 colorectal cancer cell lines. ATP11A mRNA expression was higher in colorectal cancer tissue than in corresponding normal tissue (P<0.001). Patients with high ATP11A expression showed a poorer disease-free survival rate compared to those with low expression (P<0.001), thus indicating that increase in ATP11A expression was an independent predictor of metachronous metastasis of colorectal cancer. The present study suggests that ATP11A is a useful predictive marker of metastasis in colorectal cancer patients.
MeSH terms
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ATP-Binding Cassette Transporters / genetics
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ATP-Binding Cassette Transporters / metabolism
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ATP-Binding Cassette Transporters / physiology*
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Adenocarcinoma / diagnosis*
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Adenocarcinoma / genetics
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Adenocarcinoma / mortality
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Adenocarcinoma / pathology*
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Adenosine Triphosphatases / genetics
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Adenosine Triphosphatases / physiology*
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Adult
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Aged
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Aged, 80 and over
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Biomarkers, Tumor / genetics
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Cell Line, Tumor
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Colorectal Neoplasms / diagnosis*
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Colorectal Neoplasms / genetics
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Colorectal Neoplasms / mortality
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Colorectal Neoplasms / pathology*
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Female
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Follow-Up Studies
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Gene Expression Regulation, Neoplastic
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Humans
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Male
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Middle Aged
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Neoplasm Metastasis
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Neoplasms, Second Primary / diagnosis*
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Neoplasms, Second Primary / genetics
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Neoplasms, Second Primary / mortality
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Neoplasms, Second Primary / pathology
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Prognosis
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Survival Analysis
Substances
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ATP-Binding Cassette Transporters
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Biomarkers, Tumor
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Adenosine Triphosphatases
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ATP11A protein, human