Dysfunctional social behavior has been implicated in the experience of depression. People with greater depressive symptoms report more frequent negative social interactions and react more strongly to them. It remains unknown, however, whether reaction strength differs depending on whether social interactions are positive or negative. Drawing on socio-evolutionary models of depression (N. B. Allen & P. B. T. Badcock, 2003), we proposed that people with greater depressive symptoms should not only react more strongly to negative social interactions but also to positive social interactions and a sense of belonging. Using non-clinical samples, two daily process studies examined the role of depression in people's reactivity to social interactions in natural, ongoing, social contexts. In Study 1, the number of positive and negative social events showed a stronger relation to well-being among people with greater depressive symptoms. Study 2 extended this finding to perceptions of belonging in memorable social interactions, finding a stronger link between belonging and well-being among people with greater depressive symptoms. Together these studies provide the first indication that depressive symptoms may sensitize people to everyday experiences of both social rejection and social acceptance.