Therapeutic Enzyme-Responsive Nanoparticles for Targeted Delivery and Accumulation in Tumors

Adv Mater. 2015 Aug 19;27(31):4611-5. doi: 10.1002/adma.201501803. Epub 2015 Jul 14.

Abstract

An enzyme-responsive, paclitaxel-loaded nanoparticle is described and assessed in vivo in a human fibrosarcoma murine xenograft. This work represents a proof-of-concept study demonstrating the utility of enzyme-responsive nanoscale drug carriers capable of targeted accumulation and retention in tumor tissue in response to overexpressed endogenous enzymes.

Keywords: drug delivery; enzyme-responsive; nanomaterials; self-assembly; stimuli-responsive.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / administration & dosage*
  • Cell Line, Tumor
  • Cohort Studies
  • Drug Carriers* / chemistry
  • Drug Evaluation, Preclinical
  • Fibrosarcoma / drug therapy*
  • Fibrosarcoma / enzymology
  • Fluorescence Resonance Energy Transfer
  • Humans
  • Matrix Metalloproteinases / metabolism*
  • Maximum Tolerated Dose
  • Mice, Nude
  • Micelles
  • Microscopy, Electron, Transmission
  • Nanoparticles* / chemistry
  • Neoplasm Transplantation
  • Optical Imaging
  • Paclitaxel / administration & dosage*
  • Polymers / chemistry
  • Tumor Burden

Substances

  • Antineoplastic Agents, Phytogenic
  • Drug Carriers
  • Micelles
  • Polymers
  • Matrix Metalloproteinases
  • Paclitaxel