Enhanced Diterpene Tanshinone Accumulation and Bioactivity of Transgenic Salvia miltiorrhiza Hairy Roots by Pathway Engineering

J Agric Food Chem. 2016 Mar 30;64(12):2523-30. doi: 10.1021/acs.jafc.5b04697. Epub 2016 Jan 25.

Abstract

Tanshinones are health-promoting diterpenoids found in Salvia miltiorrhiza and have wide applications. Here, SmGGPPS (geranylgeranyl diphosphate synthase) and SmDXSII (1-deoxy-D-xylulose-5-phosphate synthase) were introduced into hairy roots of S. miltiorrhiza. Overexpression of SmGGPPS and SmDXSII in hairy roots produces higher levels of tanshinone than control and single-gene transformed lines; tanshinone production in the double-gene transformed line GDII10 reached 12.93 mg/g dry weight, which is the highest tanshinone content that has been achieved through genetic engineering. Furthermore, transgenic hairy root lines showed higher antioxidant and antitumor activities than control lines. In addition, contents of chlorophylls, carotenoids, indoleacetic acid, and gibberellins were significantly elevated in transgenic Arabidopsis thaliana plants. These results demonstrate a promising method to improve the production of diterpenoids including tanshinone as well as other natural plastid-derived isoprenoids in plants by genetic manipulation of the 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway.

Keywords: MEP pathway; Salvia miltiorrhiza; hairy roots; isoprenoids; tanshinone.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abietanes / analysis*
  • Abietanes / chemistry
  • Abietanes / pharmacology
  • Abscisic Acid / metabolism
  • Algorithms
  • Animals
  • Biphenyl Compounds / pharmacology
  • Diterpenes / analysis*
  • Diterpenes / chemistry
  • Diterpenes / pharmacology
  • Erythritol / analogs & derivatives
  • Gene Expression Regulation, Plant
  • Genetic Engineering
  • Picrates / pharmacology
  • Plant Proteins / metabolism
  • Plant Roots / chemistry
  • Plant Roots / metabolism
  • Plants, Genetically Modified / chemistry
  • Plants, Genetically Modified / genetics*
  • Salvia miltiorrhiza / chemistry*
  • Salvia miltiorrhiza / genetics*
  • Sugar Phosphates
  • Transferases

Substances

  • 2-C-methylerythritol 4-phosphate
  • Abietanes
  • Biphenyl Compounds
  • Diterpenes
  • Picrates
  • Plant Proteins
  • Sugar Phosphates
  • tanshinone
  • Abscisic Acid
  • 1,1-diphenyl-2-picrylhydrazyl
  • Transferases
  • deoxyxylulose-5-phosphate synthase
  • Erythritol