Abstract
Mouse bone marrow hematopoietic stem cells were isolated with the use of a variety of phenotypic markers. These cells can proliferate and differentiate with approximately unit efficiency into myelomonocytic cells, B cells, or T cells. Thirty of these cells are sufficient to save 50 percent of lethally irradiated mice, and to reconstitute all blood cell types in the survivors.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antibodies, Monoclonal
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Antigens, Surface / immunology
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B-Lymphocytes / cytology
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Bone Marrow Cells*
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Cell Count
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Cell Differentiation
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Cell Division
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Cell Separation / methods*
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Colony-Forming Units Assay
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Erythrocytes / cytology
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Granulocytes / cytology
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Hematopoietic Stem Cell Transplantation
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Hematopoietic Stem Cells / cytology*
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Hematopoietic Stem Cells / immunology
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Mice
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Mice, Inbred C57BL
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Spleen / cytology
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T-Lymphocytes / cytology
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Thy-1 Antigens
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Thymus Gland / cytology
Substances
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Antibodies, Monoclonal
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Antigens, Surface
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Thy-1 Antigens