New therapeutic modalities for melanoma promise benefit in selected individuals. Efficacy appears greater in patients with lower tumor burden, suggesting an important role for risk-stratified surveillance. Robust predictive markers might permit optimization of agent to patient, while low-risk prognostic markers might guide more conservative management. This review evaluates protein, gene, and multiplexed marker panels that may contribute to better risk assessment and improved management of patients with cutaneous melanoma.
Keywords: gene expression profile; gene signature; melanoma; predictive biomarkers; prognostic biomarkers; protein biomarkers.
© 2018 The Authors. Journal of Surgical Oncology Published by Wiley Periodicals, Inc.