Investigation of carbapenemases and aminoglycoside modifying enzymes of Acinetobacter baumannii isolates recovered from patients admitted to intensive care units in a tertiary-care hospital in Brazil

Rev Soc Bras Med Trop. 2019 Dec 20:53:e20190044. doi: 10.1590/0037-8682-0094-2019. eCollection 2019.

Abstract

Introduction: Acinetobacter baumannii are opportunistic bacteria, highly capable of acquiring antimicrobial resistance through the production of carbapenemases and aminoglycoside modifying enzymes (AMEs).

Methods: Carbapenemase and AME genes were investigated in A. baumannii recovered from inpatients of a Brazilian hospital.

Results: The key genes found were bla OXA-51-like, the association ISAba1- bla OXA-23-like, and the AME genes aph(3´)-VI, aac(6´)-Ib, aac(3)-Ia, and aph(3´)-Ia. Different clusters spread through the institution wards.

Conclusions: The dissemination of bla OXA-23-like and AME-carrying A. baumannii through the hospital highlights the need for improved preventive measures to reduce the spread of infection.

MeSH terms

  • Acinetobacter Infections / microbiology*
  • Acinetobacter baumannii / drug effects
  • Acinetobacter baumannii / enzymology*
  • Acinetobacter baumannii / isolation & purification
  • Aminoglycosides / genetics*
  • Anti-Bacterial Agents / pharmacology*
  • Bacterial Proteins / genetics*
  • Brazil
  • Drug Resistance, Multiple, Bacterial
  • Humans
  • Intensive Care Units
  • Microbial Sensitivity Tests
  • Tertiary Care Centers
  • beta-Lactamases / genetics*

Substances

  • Aminoglycosides
  • Anti-Bacterial Agents
  • Bacterial Proteins
  • beta-Lactamases
  • carbapenemase