[¹⁸F]FDG PET/MRI enables early chemotherapy response prediction in pancreatic ductal adenocarcinoma

Purpose: In this prospective exploratory study, we evaluated the feasibility of [¹⁸F]fluorodeoxyglucose ([¹⁸F]FDG) PET/MRI-based chemotherapy response prediction in pancreatic ductal adenocarcinoma at two weeks upon therapy onset.

Material and methods: In a mixed cohort, seventeen patients treated with chemotherapy in neoadjuvant or palliative intent were enrolled. All patients were imaged by [¹⁸F]FDG PET/MRI before and two weeks after onset of chemotherapy. Response per RECIST1.1 was then assessed at 3 months [¹⁸F]FDG PET/MRI-derived parameters (MTV_50%, TLG_50%, MTV_2.5, TLG_2.5, SUV_max, SUV_peak, ADC_max, ADC_mean and ADC_min) were assessed, using multiple t-test, Man-Whitney-U test and Fisher's exact test for binary features.

Results: At 72 ± 43 days, twelve patients were classified as responders and five patients as non-responders. An increase in ∆MTV_50% and ∆ADC (≥ 20% and 15%, respectively) and a decrease in ∆TLG_50% (≤ 20%) at 2 weeks after chemotherapy onset enabled prediction of responders and non-responders, respectively. Parameter combinations (∆TLG_50% and ∆ADC_max or ∆MTV_50% and ∆ADC_max) further improved discrimination.

Conclusion: Multiparametric [¹⁸F]FDG PET/MRI-derived parameters, in particular indicators of a change in tumor glycolysis and cellularity, may enable very early chemotherapy response prediction. Further prospective studies in larger patient cohorts are recommended to their clinical impact.