Zhen XC - Search Results

1

Allosteric Modulation of Sigma-1 Receptors Elicits Rapid Antidepressant Activity.

Wang Y, Guo L, Jiang HF, Zheng LT, Zhang A, Zhen XC. Wang Y, et al. Among authors: zhen xc. CNS Neurosci Ther. 2016 May;22(5):368-77. doi: 10.1111/cns.12502. Epub 2016 Feb 8. CNS Neurosci Ther. 2016. PMID: 26854125 Free PMC article.

2

SKF83959 is a potent allosteric modulator of sigma-1 receptor.

Guo L, Zhao J, Jin G, Zhao B, Wang G, Zhang A, Zhen X. Guo L, et al. Mol Pharmacol. 2013 Mar;83(3):577-86. doi: 10.1124/mol.112.083840. Epub 2013 Jan 7. Mol Pharmacol. 2013. PMID: 23295385

3

Allosteric modulation of sigma-1 receptors elicits anti-seizure activities.

Guo L, Chen Y, Zhao R, Wang G, Friedman E, Zhang A, Zhen X. Guo L, et al. Br J Pharmacol. 2015 Aug;172(16):4052-65. doi: 10.1111/bph.13195. Epub 2015 Jun 26. Br J Pharmacol. 2015. PMID: 25989224 Free PMC article.

4

Allosteric modulation of sigma-1 receptors by SKF83959 inhibits microglia-mediated inflammation.

Wu Z, Li L, Zheng LT, Xu Z, Guo L, Zhen X. Wu Z, et al. J Neurochem. 2015 Sep;134(5):904-14. doi: 10.1111/jnc.13182. Epub 2015 Jun 19. J Neurochem. 2015. PMID: 26031312 Free article.

5

SKF83959 is a novel triple reuptake inhibitor that elicits anti-depressant activity.

Fang X, Guo L, Jia J, Jin GZ, Zhao B, Zheng YY, Li JQ, Zhang A, Zhen XC. Fang X, et al. Among authors: zhen xc. Acta Pharmacol Sin. 2013 Sep;34(9):1149-55. doi: 10.1038/aps.2013.66. Epub 2013 Jul 29. Acta Pharmacol Sin. 2013. PMID: 23892272 Free PMC article.

6

Activation of Nur77 in microglia attenuates proinflammatory mediators production and protects dopaminergic neurons from inflammation-induced cell death.

Liu TY, Yang XY, Zheng LT, Wang GH, Zhen XC. Liu TY, et al. Among authors: zhen xc. J Neurochem. 2017 Feb;140(4):589-604. doi: 10.1111/jnc.13907. Epub 2016 Dec 21. J Neurochem. 2017. PMID: 27889907 Free article.

7

Development and characterization of an inducible Dicer conditional knockout mouse model of Parkinson's disease: validation of the antiparkinsonian effects of a sigma-1 receptor agonist and dihydromyricetin.

Guo CH, Cao T, Zheng LT, Waddington JL, Zhen XC. Guo CH, et al. Among authors: zhen xc. Acta Pharmacol Sin. 2020 Apr;41(4):499-507. doi: 10.1038/s41401-020-0379-5. Epub 2020 Feb 28. Acta Pharmacol Sin. 2020. PMID: 32112040 Free PMC article.

8

SKF83959 suppresses excitatory synaptic transmission in rat hippocampus via a dopamine receptor-independent mechanism.

Chu HY, Wu Q, Zhou S, Cao X, Zhang A, Jin GZ, Hu GY, Zhen X. Chu HY, et al. J Neurosci Res. 2011 Aug;89(8):1259-66. doi: 10.1002/jnr.22653. Epub 2011 May 2. J Neurosci Res. 2011. PMID: 21538463

9

Identification of N-propylnoraporphin-11-yl 5-(1,2-dithiolan-3-yl)pentanoate as a new anti-Parkinson's agent possessing a dopamine D2 and serotonin 5-HT1A dual-agonist profile.

Zhang H, Ye N, Zhou S, Guo L, Zheng L, Liu Z, Gao B, Zhen X, Zhang A. Zhang H, et al. J Med Chem. 2011 Jul 14;54(13):4324-38. doi: 10.1021/jm200347t. Epub 2011 Jun 2. J Med Chem. 2011. PMID: 21591752

10

(6aR)-11-amino-N-propyl-noraporphine, a new dopamine D2 and serotonin 5-HT1A dual agonist, elicits potent antiparkinsonian action and attenuates levodopa-induced dyskinesia in a 6-OHDA-lesioned rat model of Parkinson's disease.

Zhao R, Lu W, Fang X, Guo L, Yang Z, Ye N, Zhao J, Liu Z, Jia J, Zheng L, Zhao B, Zhang A, Zhen X. Zhao R, et al. Pharmacol Biochem Behav. 2014 Sep;124:204-10. doi: 10.1016/j.pbb.2014.06.011. Epub 2014 Jun 21. Pharmacol Biochem Behav. 2014. PMID: 24955866

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