Sawada Y - Search Results

1

Development of a potent and orally active activator of adenosine monophosphate-activated protein kinase (AMPK), ASP4132, as a clinical candidate for the treatment of human cancer.

Kuramoto K, Yamada H, Shin T, Sawada Y, Azami H, Yamada T, Nagashima T, Ohnuki K. Kuramoto K, et al. Among authors: sawada y. Bioorg Med Chem. 2020 Mar 1;28(5):115307. doi: 10.1016/j.bmc.2020.115307. Epub 2020 Jan 8. Bioorg Med Chem. 2020. PMID: 32007387

2

Discovery of 3,5-Dimethylpyridin-4(1H)-one Derivatives as Activators of AMP-Activated Protein Kinase (AMPK).

Kuramoto K, Sawada Y, Ishibashi N, Yamada T, Nagashima T, Shin T. Kuramoto K, et al. Among authors: sawada y. Chem Pharm Bull (Tokyo). 2020;68(1):77-90. doi: 10.1248/cpb.c19-00800. Chem Pharm Bull (Tokyo). 2020. PMID: 31902903 Free article.

3

Novel Indirect AMP-Activated Protein Kinase Activators: Identification of a Second-Generation Clinical Candidate with Improved Physicochemical Properties and Reduced hERG Inhibitory Activity.

Kuramoto K, Sawada Y, Yamada T, Nagashima T, Ohnuki K, Shin T. Kuramoto K, et al. Among authors: sawada y. Chem Pharm Bull (Tokyo). 2020;68(5):452-465. doi: 10.1248/cpb.c20-00015. Chem Pharm Bull (Tokyo). 2020. PMID: 32378543 Free article.

4

Identification of 4-quinolone derivatives as inhibitors of reactive oxygen species production from human umbilical vein endothelial cells.

Onda K, Narazaki F, Ishibashi N, Nakanishi K, Sawada Y, Imamura K, Momose K, Furukawa S, Shimada Y, Moriguchi H, Yuda M, Kayakiri H, Ohta M. Onda K, et al. Among authors: sawada y. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6861-6. doi: 10.1016/j.bmcl.2011.09.015. Epub 2011 Sep 10. Bioorg Med Chem Lett. 2011. PMID: 21963985

5

A new series of highly potent non-peptide bradykinin B2 receptor antagonists incorporating the 4-heteroarylquinoline framework. Improvement of aqueous solubility and new insights into species difference.

Sawada Y, Kayakiri H, Abe Y, Imai K, Mizutani T, Inamura N, Asano M, Aramori I, Hatori C, Katayama A, Oku T, Tanaka H. Sawada Y, et al. J Med Chem. 2004 Mar 25;47(7):1617-30. doi: 10.1021/jm030159x. J Med Chem. 2004. PMID: 15027853

6

Discovery of the first non-peptide full agonists for the human bradykinin B(2) receptor incorporating 4-(2-picolyloxy)quinoline and 1-(2-picolyl)benzimidazole frameworks.

Sawada Y, Kayakiri H, Abe Y, Mizutani T, Inamura N, Asano M, Hatori C, Aramori I, Oku T, Tanaka H. Sawada Y, et al. J Med Chem. 2004 May 20;47(11):2853-63. doi: 10.1021/jm030468n. J Med Chem. 2004. PMID: 15139763

7

A new class of nonpeptide bradykinin B(2) receptor ligand, incorporating a 4-aminoquinoline framework. Identification of a key pharmacophore to determine species difference and agonist/antagonist profile.

Sawada Y, Kayakiri H, Abe Y, Mizutani T, Inamura N, Asano M, Aramori I, Hatori C, Oku T, Tanaka H. Sawada Y, et al. J Med Chem. 2004 May 6;47(10):2667-77. doi: 10.1021/jm030326t. J Med Chem. 2004. PMID: 15115408

8

Multidimensional Benefits of a Tailored Exercise Program in Preventing Frailty: A Community-Based Approach.

Kakuda A, Sawada Y, Okumura R, Kinoshita H, Anme T. Kakuda A, et al. Among authors: sawada y. Healthcare (Basel). 2024 Nov 1;12(21):2183. doi: 10.3390/healthcare12212183. Healthcare (Basel). 2024. PMID: 39517394 Free PMC article.

9

A potential evolutionary trap for the extended phenotype of a nematomorph parasite.

Sawada Y, Sato N, Osawa T, Matsumoto K, Chiu MC, Okada R, Sakura M, Sato T. Sawada Y, et al. PNAS Nexus. 2024 Oct 15;3(10):pgae464. doi: 10.1093/pnasnexus/pgae464. eCollection 2024 Oct. PNAS Nexus. 2024. PMID: 39474501 Free PMC article.

10

A Case of Cutaneous Blastic Plasmacytoid Dendritic Cell Neoplasm on the Chest.

Tokioka R, Saito-Sasaki N, Sawada Y. Tokioka R, et al. Among authors: sawada y. Cureus. 2024 Sep 26;16(9):e70288. doi: 10.7759/cureus.70288. eCollection 2024 Sep. Cureus. 2024. PMID: 39463539 Free PMC article.

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