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Page 1
Molecular Subtypes of Pulmonary Large-cell Neuroendocrine Carcinoma Predict Chemotherapy Treatment Outcome.
Derks JL, Leblay N, Thunnissen E, van Suylen RJ, den Bakker M, Groen HJM, Smit EF, Damhuis R, van den Broek EC, Charbrier A, Foll M, McKay JD, Fernandez-Cuesta L, Speel EM, Dingemans AC; PALGA-Group. Derks JL, et al. Clin Cancer Res. 2018 Jan 1;24(1):33-42. doi: 10.1158/1078-0432.CCR-17-1921. Epub 2017 Oct 24. Clin Cancer Res. 2018. PMID: 29066508
We assessed whether these subtypes have a predictive value on chemotherapy outcome.Experimental Design: Clinical data and tumor specimens were retrospectively obtained from the Netherlands Cancer Registry and Pathology Registry. ...
We assessed whether these subtypes have a predictive value on chemotherapy outcome.Experimental Design: Clinical data and tumor speci …
Chemotherapy for pulmonary large cell neuroendocrine carcinomas: does the regimen matter?
Derks JL, van Suylen RJ, Thunnissen E, den Bakker MA, Groen HJ, Smit EF, Damhuis RA, van den Broek EC, Speel EM, Dingemans AC; PALGA group. Derks JL, et al. Eur Respir J. 2017 Jun 1;49(6):1601838. doi: 10.1183/13993003.01838-2016. Print 2017 Jun. Eur Respir J. 2017. PMID: 28572122 Free PMC article.
Pulmonary large cell neuroendocrine carcinoma (LCNEC) is rare. Chemotherapy for metastatic LCNEC ranges from small cell lung carcinoma (SCLC) regimens to nonsmall cell lung carcinoma (NSCLC) chemotherapy regimens. ...
Pulmonary large cell neuroendocrine carcinoma (LCNEC) is rare. Chemotherapy for metastatic LCNEC ranges f …
Combined large cell neuroendocrine carcinoma: clinical characteristics, prognosis and postoperative management.
Yang Z, Wang Y, Chen Y, Qian F, Zhang Y, Hu M, Zhang W, Han B. Yang Z, et al. Eur J Cardiothorac Surg. 2022 Jul 11;62(2):ezac069. doi: 10.1093/ejcts/ezac069. Eur J Cardiothorac Surg. 2022. PMID: 35147672
OBJECTIVES: Combined large cell neuroendocrine carcinoma (C-LCNEC) is pulmonary large cell neuroendocrine carcinoma (LCNEC) mixed with other components, such as adenocarcinoma (AD) and squamous cell carcinoma (SCC). ...
OBJECTIVES: Combined large cell neuroendocrine carcinoma (C-LCNEC) is pulmonary large cell neuroendocrine car …
Efficacy of second-line chemotherapy in patients with pulmonary large cell neuroendocrine carcinoma.
Iida Y, Wakuda K, Kenmotsu H, Doshita K, Kodama H, Nishioka N, Miyawaki E, Miyawaki T, Mamesaya N, Kobayashi H, Omori S, Ko R, Ono A, Naito T, Murakami H, Sugino T, Gon Y, Takahashi T. Iida Y, et al. Sci Rep. 2024 Apr 1;14(1):7641. doi: 10.1038/s41598-024-58327-w. Sci Rep. 2024. PMID: 38561461 Free PMC article.
The efficacy of second-line chemotherapy in patients with pulmonary large cell neuroendocrine carcinoma (LCNEC) is unclear. This study aimed to evaluate the efficacy of second-line chemotherapy in patients with pulmonary LCNEC. ...
The efficacy of second-line chemotherapy in patients with pulmonary large cell neuroendocrine carcinoma ( …
Different Characteristics and Survival between Surgically Resected Pure and Combined Pulmonary Large Cell Neuroendocrine Carcinoma.
Wang Y, Chen Y, Yang Z, Qian F, Hu M, Lu J, Zhang Y, Zhang W, Wang K, Han B. Wang Y, et al. Ann Surg Oncol. 2022 Sep;29(9):5666-5678. doi: 10.1245/s10434-022-11610-4. Epub 2022 May 11. Ann Surg Oncol. 2022. PMID: 35543906 Review.
METHODS: We reviewed 221 patients with pure LCNEC (P-LCNEC) and 120 patients with combined LCNEC (C-LCNEC) who underwent pulmonary surgery in our hospital to compare their clinical features, driven genes' status (EGFR/ALK/ROS1/KRAS/BRAF), and adjuvant chemotherapy regimens …
METHODS: We reviewed 221 patients with pure LCNEC (P-LCNEC) and 120 patients with combined LCNEC (C-LCNEC) who underwent pulmonary surgery i …
Disparity in clinical outcomes between pure and combined pulmonary large-cell neuroendocrine carcinoma: A multi-center retrospective study.
Zhang JT, Li Y, Yan LX, Zhu ZF, Dong XR, Chu Q, Wu L, Zhang HM, Xu CW, Lin G, Yu ZY, Hu J, Zhu B, Wang HJ, Yang F, Song ZB, Han ZB, Li MX, Lin J, Wu YL, Wang JL, Zhong WZ. Zhang JT, et al. Lung Cancer. 2020 Jan;139:118-123. doi: 10.1016/j.lungcan.2019.11.004. Epub 2019 Nov 11. Lung Cancer. 2020. PMID: 31775086 Free article.
OBJECTIVES: The 2015 World Health Organization classification defines pulmonary large-cell neuroendocrine carcinoma (LCNEC) as a high-grade neuroendocrine carcinoma. However, the clinical characteristics and prognostic factors of pure LCN …
OBJECTIVES: The 2015 World Health Organization classification defines pulmonary large-cell neuroendocrine car …
Complete remission of combined pulmonary large cell neuroendocrine carcinoma: a case report.
Xu J, Feng Q, Chen Y, Liu XL, Jiang O. Xu J, et al. J Int Med Res. 2021 Nov;49(11):3000605211055387. doi: 10.1177/03000605211055387. J Int Med Res. 2021. PMID: 34738481 Free PMC article.
Pulmonary large cell neuroendocrine carcinoma (LCNEC), which accounts for approximately 1% of all lung cancers, is a rare and highly aggressive malignancy with a poor prognosis. ...
Pulmonary large cell neuroendocrine carcinoma (LCNEC), which accounts for approximately 1% of all lung ca …
Prognostic nomogram predicts overall survival in pulmonary large cell neuroendocrine carcinoma.
He Y, Liu H, Wang S, Chen Y. He Y, et al. PLoS One. 2019 Sep 27;14(9):e0223275. doi: 10.1371/journal.pone.0223275. eCollection 2019. PLoS One. 2019. PMID: 31560723 Free PMC article.
RESULTS: Of 3048 eligible patients with LCNEC, 2138 were randomly grouped into the training set and 910 into the validation set. Age at diagnosis, gender, tumor stage, N stage, tumor size, and surgery of primary site were independent prognostic factors of OS. ...Use of thi …
RESULTS: Of 3048 eligible patients with LCNEC, 2138 were randomly grouped into the training set and 910 into the validation set. Age …
Complete and durable response of pulmonary large-cell neuroendocrine carcinoma to pembrolizumab.
Kadota N, Hatakeyama N, Hino H, Kunishige M, Kondo Y, Okano Y, Machida H, Naruse K, Shinohara T, Sakiyama S, Ogushi F, Takeuchi E. Kadota N, et al. Cancer Rep (Hoboken). 2022 Aug;5(8):e1589. doi: 10.1002/cnr2.1589. Epub 2021 Nov 24. Cancer Rep (Hoboken). 2022. PMID: 34817132 Free PMC article.
BACKGROUND: Pulmonary large cell neuroendocrine carcinoma (LCNEC) is a rare and aggressive tumor with a poor prognosis and standard therapy has not yet been established. ...
BACKGROUND: Pulmonary large cell neuroendocrine carcinoma (LCNEC) is a rare and aggressive tumor with a p …
Comprehensive expressional analysis of chemosensitivity-related markers in large cell neuroendocrine carcinoma of the lung.
Ohtaki Y, Kaira K, Yajima T, Erkhem-Ochir B, Kawashima O, Kamiyoshihara M, Igai H, Onozato R, Ibe T, Kosaka T, Nakazawa S, Nagashima T, Oyama T, Shirabe K. Ohtaki Y, et al. Thorac Cancer. 2021 Oct;12(20):2666-2679. doi: 10.1111/1759-7714.14102. Epub 2021 Aug 28. Thorac Cancer. 2021. PMID: 34453496 Free PMC article.
Detailed expression profiles of sensitivity markers for cytotoxic chemotherapy in pulmonary large cell neuroendocrine carcinoma (LCNEC) remain unclear. Herein, we aimed to clarify the correlation between the expression of drug-sensitivity marker …
Detailed expression profiles of sensitivity markers for cytotoxic chemotherapy in pulmonary large cell neuroendocrin …
29 results