Beyond Warburg: LDHA activates RAC for tumour growth

Natsuski Osaka; Atsuo T Sasaki

doi:10.1038/s42255-022-00709-3

Beyond Warburg: LDHA activates RAC for tumour growth

Nat Metab. 2022 Dec;4(12):1623-1625. doi: 10.1038/s42255-022-00709-3.

Authors

Natsuski Osaka¹, Atsuo T Sasaki^{2

3

4

5}

Affiliations

¹ Institute for Advanced Biosciences, Keio University, Tsuruoka, Japan.
² Institute for Advanced Biosciences, Keio University, Tsuruoka, Japan. [email protected].
³ Division of Hematology and Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA. [email protected].
⁴ Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH, USA. [email protected].
⁵ Department of Neurosurgery, Brain Tumor Center at UC Gardner Neuroscience Institute, Cincinnati, OH, USA. [email protected].

Abstract

The physiological role of aerobic glycolysis (also known as the Warburg effect), which is observed in many tumours, is still not fully understood. The finding that lactate dehydrogenase A (LDHA) activates RAC1 in breast cancer sheds new light on this persistently enigmatic aspect of cancer metabolism.

Publication types

Comment

MeSH terms

Humans
Lactate Dehydrogenase 5
Neoplasms*

Substances

Lactate Dehydrogenase 5

Grants and funding

R01 CA255331/CA/NCI NIH HHS/United States