Editorial: Gateway to monocyte entry into the brain: CXCR7, the new orchestra conductor

Steven D Douglas; Sergei Spitsin

doi:10.1189/jlb.3CE0717-273R

Editorial: Gateway to monocyte entry into the brain: CXCR7, the new orchestra conductor

J Leukoc Biol. 2017 Nov;102(5):1155-1157. doi: 10.1189/jlb.3CE0717-273R.

Authors

Steven D Douglas^{1

2}, Sergei Spitsin³

Affiliations

¹ Children's Hospital of Philadelphia Research Institute, Philadelphia, Pennsylvania, USA and [email protected].
² Division of Allergy and Immunology, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
³ Children's Hospital of Philadelphia Research Institute, Philadelphia, Pennsylvania, USA and.

Abstract

Discussion on the potential role for CXCR7 as a major signaling pathway for CD14⁺CD16⁺ monocyte transmigration across the blood brain barrier, and its therapeutic application for NeuroAIDS.

Keywords: CCX771; CXCL12; HIV; chemotaxis.

Publication types

Editorial
Research Support, N.I.H., Extramural
Comment

MeSH terms

Brain
Cell Line, Tumor
Chemokine CXCL12
Monocytes*
Receptors, CXCR*
Receptors, CXCR4
Signal Transduction

Substances

Chemokine CXCL12
Receptors, CXCR
Receptors, CXCR4

Abstract

Publication types

MeSH terms

Substances

Grants and funding