Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

Ontology Browser
Term:
Parent Terms Term With Siblings Child Terms
[cytochrome c]-lysine N-methyltransferase activity 
calmodulin-lysine N-methyltransferase activity  
histone H3K27 methyltransferase activity +   
histone H3K36 methyltransferase activity +   
histone H3K37 methyltransferase activity  
histone H3K4 methyltransferase activity +   
Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of up to three methyl groups to the lysine residue at position 4 of the histone H3 protein.
histone H3K56 methyltransferase activity  
histone H3K79 methyltransferase activity +   
histone H3K9 methyltransferase activity +   
histone H3R17 methyltransferase activity  
histone H3R2 methyltransferase activity  
histone H3R26 methyltransferase activity  
histone H3R8 methyltransferase activity  
histone H4K12 methyltransferase activity  
histone H4K20 methyltransferase activity +   

Synonyms
Exact Synonyms: histone H3 lysine 4-specific methyltransferase activity ;   histone H3K4 methylase activity ;   histone lysine N-methyltransferase activity (H3-K4 specific) ;   histone methylase activity (H3-K4 specific) ;   histone methyltransferase activity (H3-K4 specific)
Xrefs: reactome:R-HSA-1214188 "PRDM9 trimethylates histone H3" ;   reactome:R-HSA-3364026 "SET1 complex trimethylates H3K4 at the MYC gene" ;   reactome:R-HSA-8865498 "KMT2A trimethylates nucleosomes at the SPI1 gene locus producing H3K4Me3 mark" ;   reactome:R-HSA-8936481 "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter" ;   reactome:R-HSA-8936621 "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter" ;   reactome:R-HSA-8937016 "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter" ;   reactome:R-HSA-8937050 "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter"
Definition Sources: PMID:12086618

paths to the root