Ehmt2 (euchromatic histone lysine methyltransferase 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Ehmt2 (euchromatic histone lysine methyltransferase 2) Rattus norvegicus
Analyze
Symbol: Ehmt2
Name: euchromatic histone lysine methyltransferase 2
RGD ID: 1302972
Description: Predicted to enable several functions, including C2H2 zinc finger domain binding activity; p53 binding activity; and protein-lysine N-methyltransferase activity. Involved in several processes, including long-term memory; response to ethanol; and response to fungicide. Located in nucleus. Biomarker of fetal alcohol spectrum disorder. Human ortholog(s) of this gene implicated in idiopathic pulmonary fibrosis. Orthologous to human EHMT2 (euchromatic histone lysine methyltransferase 2); PARTICIPATES IN histone modification pathway; lysine degradation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Bat8; euchromatic histone lysine N-methyltransferase 2; euchromatic histone-lysine N-methyltransferase 2; G9a; histone-lysine N-methyltransferase EHMT2; histone-lysine N-methyltransferase, H3 lysine-9 specific 3; HLA-B associated transcript 8, rat orthologue; Ng36
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8203,924,263 - 3,941,238 (-)NCBIGRCr8
mRatBN7.2203,919,623 - 3,936,751 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl203,919,624 - 3,941,547 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx204,619,529 - 4,635,983 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0203,981,271 - 3,997,725 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0204,518,475 - 4,534,917 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0204,576,033 - 4,592,980 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,576,057 - 4,592,980 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,656,049 - 6,672,967 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,021,679 - 4,033,709 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1204,021,905 - 4,033,936 (-)NCBI
Celera204,093,733 - 4,109,892 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetylsalicylic acid  (ISO)
afatinib  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol F  (EXP)
bortezomib  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cocaine  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
desferrioxamine B  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
dimethylarsinic acid  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
FR900359  (ISO)
glyphosate  (EXP)
hydralazine  (ISO)
hydroquinone  (ISO)
hypochlorous acid  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
melatonin  (ISO)
methamphetamine  (ISO)
methidathion  (ISO)
methimazole  (EXP)
methoxychlor  (ISO)
morphine  (ISO)
myo-inositol hexakisphosphate  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitric oxide  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
phenylmercury acetate  (ISO)
potassium dichromate  (ISO)
rimonabant  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sepantronium  (ISO)
sodium arsenite  (EXP,ISO)
sulfadimethoxine  (EXP)
sulindac  (ISO)
testosterone  (ISO)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IBA,ISO)
nuclear speck  (IEA,ISO)
nucleolus  (ISO)
nucleoplasm  (ISO)
nucleus  (IBA,IDA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Coexpression of nuclear receptors and histone methylation modifying genes in the testis: implications for endocrine disruptor modes of action. Anderson AM, etal., PLoS One. 2012;7(4):e34158. doi: 10.1371/journal.pone.0034158. Epub 2012 Apr 4.
2. Gestational choline supplementation normalized fetal alcohol-induced alterations in histone modifications, DNA methylation, and proopiomelanocortin (POMC) gene expression in beta-endorphin-producing POMC neurons of the hypothalamus. Bekdash RA, etal., Alcohol Clin Exp Res. 2013 Jul;37(7):1133-42. doi: 10.1111/acer.12082. Epub 2013 Feb 15.
3. Histone lysine methylation dynamics: establishment, regulation, and biological impact. Black JC, etal., Mol Cell. 2012 Nov 30;48(4):491-507. doi: 10.1016/j.molcel.2012.11.006.
4. H3K9 histone methyltransferase G9a promotes lung cancer invasion and metastasis by silencing the cell adhesion molecule Ep-CAM. Chen MW, etal., Cancer Res. 2010 Oct 15;70(20):7830-40. doi: 10.1158/0008-5472.CAN-10-0833. Epub 2010 Oct 12.
5. A central role for G9a and EZH2 in the epigenetic silencing of cyclooxygenase-2 in idiopathic pulmonary fibrosis. Coward WR, etal., FASEB J. 2014 Jul;28(7):3183-96. doi: 10.1096/fj.13-241760. Epub 2014 Mar 20.
6. Gestational choline supply regulates methylation of histone H3, expression of histone methyltransferases G9a (Kmt1c) and Suv39h1 (Kmt1a), and DNA methylation of their genes in rat fetal liver and brain. Davison JM, etal., J Biol Chem. 2009 Jan 23;284(4):1982-9. doi: 10.1074/jbc.M807651200. Epub 2008 Nov 10.
7. Genetic variants of methyl metabolizing enzymes and epigenetic regulators: associations with promoter CpG island hypermethylation in colorectal cancer. de Vogel S, etal., Cancer Epidemiol Biomarkers Prev. 2009 Nov;18(11):3086-96. doi: 10.1158/1055-9965.EPI-09-0289. Epub 2009 Oct 20.
8. Fetal Alcohol Exposure Reduces Dopamine Receptor D2 and Increases Pituitary Weight and Prolactin Production via Epigenetic Mechanisms. Gangisetty O, etal., PLoS One. 2015 Oct 28;10(10):e0140699. doi: 10.1371/journal.pone.0140699. eCollection 2015.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. G9a/GLP histone lysine dimethyltransferase complex activity in the hippocampus and the entorhinal cortex is required for gene activation and silencing during memory consolidation. Gupta-Agarwal S, etal., J Neurosci. 2012 Apr 18;32(16):5440-53. doi: 10.1523/JNEUROSCI.0147-12.2012.
11. The methyltransferase G9a regulates HoxA9-dependent transcription in AML. Lehnertz B, etal., Genes Dev. 2014 Feb 15;28(4):317-27. doi: 10.1101/gad.236794.113.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Immunohistochemistry for histone h3 lysine 9 methyltransferase and demethylase proteins in human melanomas. Miura S, etal., Am J Dermatopathol. 2014 Mar;36(3):211-6. doi: 10.1097/DAD.0b013e3182964e02.
14. Readout of epigenetic modifications. Patel DJ and Wang Z, Annu Rev Biochem. 2013;82:81-118. doi: 10.1146/annurev-biochem-072711-165700.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. GOA pipeline RGD automated data pipeline
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Role of histone methyltransferase G9a in CpG methylation of the Prader-Willi syndrome imprinting center. Xin Z, etal., J Biol Chem 2003 Apr 25;278(17):14996-5000. Epub 2003 Feb 13.
19. Abnormal epigenetic modifications in peripheral blood mononuclear cells from patients with alopecia areata. Zhao M, etal., Br J Dermatol. 2012 Feb;166(2):226-73. doi: 10.1111/j.1365-2133.2011.10646.x. Epub 2012 Jan 9.
20. Overexpressions of G9a and MCM7 in Esophageal Squamous Cell Carcinoma Associated with Poor Prognosis. Zhong X, etal., Histopathology. 2014 May 7. doi: 10.1111/his.12456.
21. Antidepressants inhibit DNA methyltransferase 1 through reducing G9a levels. Zimmermann N, etal., Biochem J. 2012 Nov 15;448(1):93-102. doi: 10.1042/BJ20120674.
Additional References at PubMed
PMID:15493016   PMID:15774718   PMID:15788566   PMID:16702210   PMID:17212651   PMID:17392792   PMID:17599069   PMID:17707230   PMID:18818694   PMID:19144645   PMID:20118233   PMID:21402781  
PMID:22387026   PMID:22770845   PMID:23918802   PMID:24584053   PMID:25607239   PMID:26917724   PMID:27893464   PMID:27932493   PMID:28665013   PMID:29217682   PMID:30587852   PMID:32402271  
PMID:32671696   PMID:33450132   PMID:34672892   PMID:34830365   PMID:35439934  


Genomics

Comparative Map Data
Ehmt2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8203,924,263 - 3,941,238 (-)NCBIGRCr8
mRatBN7.2203,919,623 - 3,936,751 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl203,919,624 - 3,941,547 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx204,619,529 - 4,635,983 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0203,981,271 - 3,997,725 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0204,518,475 - 4,534,917 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0204,576,033 - 4,592,980 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,576,057 - 4,592,980 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,656,049 - 6,672,967 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,021,679 - 4,033,709 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1204,021,905 - 4,033,936 (-)NCBI
Celera204,093,733 - 4,109,892 (+)NCBICelera
Cytogenetic Map20p12NCBI
EHMT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38631,879,759 - 31,897,698 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl631,879,759 - 31,897,698 (-)EnsemblGRCh38hg38GRCh38
GRCh37631,847,536 - 31,865,475 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36631,955,515 - 31,973,443 (-)NCBINCBI36Build 36hg18NCBI36
Celera633,446,117 - 33,464,048 (-)NCBICelera
Cytogenetic Map6p21.33NCBI
HuRef631,633,340 - 31,651,520 (-)NCBIHuRef
CHM1_1631,849,677 - 31,867,605 (-)NCBICHM1_1
T2T-CHM13v2.0631,732,994 - 31,750,940 (-)NCBIT2T-CHM13v2.0
Ehmt2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391735,117,427 - 35,133,049 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1735,117,445 - 35,133,028 (+)EnsemblGRCm39 Ensembl
GRCm381734,898,463 - 34,914,073 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,898,469 - 34,914,052 (+)EnsemblGRCm38mm10GRCm38
MGSCv371735,035,444 - 35,050,992 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361734,506,555 - 34,522,103 (+)NCBIMGSCv36mm8
Celera1737,993,807 - 38,010,279 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.45NCBI
Ehmt2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955437396,742 - 411,144 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955437396,736 - 411,144 (-)NCBIChiLan1.0ChiLan1.0
EHMT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2546,358,802 - 46,376,755 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1642,320,293 - 42,338,260 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0631,542,946 - 31,560,894 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1632,429,265 - 32,446,860 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl632,429,271 - 32,451,844 (-)Ensemblpanpan1.1panPan2
EHMT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1121,341,202 - 1,354,602 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl121,341,191 - 1,354,584 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha121,476,470 - 1,489,841 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0121,483,381 - 1,496,739 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl121,483,381 - 1,497,535 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1121,341,088 - 1,354,451 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0121,409,030 - 1,422,401 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0121,474,485 - 1,487,852 (-)NCBIUU_Cfam_GSD_1.0
Ehmt2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494635,898,050 - 35,912,895 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367271,648,448 - 1,663,455 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367271,648,451 - 1,663,294 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EHMT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl723,977,683 - 23,993,478 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1723,977,683 - 23,992,673 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2727,818,555 - 27,834,344 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EHMT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11740,123,935 - 40,141,942 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1740,124,640 - 40,141,616 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604431,794,809 - 31,812,826 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ehmt2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475424,354,284 - 24,368,638 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475424,354,271 - 24,368,319 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ehmt2
122 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:212
Count of miRNA genes:131
Interacting mature miRNAs:152
Transcripts:ENSRNOT00000047370
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61472Aia1Adjuvant induced arthritis QTL 1180.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2026463954597031Rat
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015279595304575Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126123605Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
61448Ciaa1CIA Autoantibody QTL 1300.001blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)2026463954597031Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362164910078919Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036216499243559Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
737973Pia21Pristane induced arthritis QTL 214.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2036216564606812Rat

Markers in Region
D17Ertd710e  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2203,919,638 - 3,919,863 (-)MAPPERmRatBN7.2
Rnor_6.0204,592,741 - 4,592,965NCBIRnor6.0
Rnor_5.0206,672,728 - 6,672,952UniSTSRnor5.0
RGSC_v3.4204,021,694 - 4,021,918UniSTSRGSC3.4
Celera204,109,653 - 4,109,877UniSTS
Cytogenetic Map20p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000047370   ⟹   ENSRNOP00000042145
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl203,919,624 - 3,936,257 (-)Ensembl
Rnor_6.0 Ensembl204,576,534 - 4,592,980 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000081456   ⟹   ENSRNOP00000071106
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl203,919,624 - 3,941,547 (-)Ensembl
Rnor_6.0 Ensembl204,576,057 - 4,592,980 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000085701   ⟹   ENSRNOP00000068632
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl203,919,624 - 3,941,547 (-)Ensembl
Rnor_6.0 Ensembl204,576,062 - 4,592,980 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090125   ⟹   ENSRNOP00000074605
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl204,576,514 - 4,592,973 (+)Ensembl
RefSeq Acc Id: NM_212463   ⟹   NP_997628
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8203,924,263 - 3,940,710 (-)NCBI
mRatBN7.2203,919,624 - 3,936,076 (-)NCBI
Rnor_6.0204,576,534 - 4,592,980 (+)NCBI
Rnor_5.0206,656,049 - 6,672,967 (+)NCBI
RGSC_v3.4204,021,679 - 4,033,709 (-)RGD
Celera204,093,733 - 4,109,892 (+)RGD
Sequence:
RefSeq Acc Id: XM_006255954   ⟹   XP_006256016
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8203,924,263 - 3,941,092 (-)NCBI
mRatBN7.2203,919,623 - 3,936,118 (-)NCBI
Rnor_6.0204,576,519 - 4,592,980 (+)NCBI
Rnor_5.0206,656,049 - 6,672,967 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006255955   ⟹   XP_006256017
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8203,924,263 - 3,941,092 (-)NCBI
mRatBN7.2203,919,623 - 3,936,118 (-)NCBI
Rnor_6.0204,576,519 - 4,592,980 (+)NCBI
Rnor_5.0206,656,049 - 6,672,967 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006255956   ⟹   XP_006256018
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8203,924,263 - 3,941,092 (-)NCBI
mRatBN7.2203,919,623 - 3,936,117 (-)NCBI
Rnor_6.0204,576,519 - 4,592,980 (+)NCBI
Rnor_5.0206,656,049 - 6,672,967 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006255957   ⟹   XP_006256019
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8203,924,263 - 3,941,238 (-)NCBI
mRatBN7.2203,919,623 - 3,936,751 (-)NCBI
Rnor_6.0204,576,033 - 4,592,980 (+)NCBI
Rnor_5.0206,656,049 - 6,672,967 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006255958   ⟹   XP_006256020
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8203,924,263 - 3,941,238 (-)NCBI
mRatBN7.2203,919,623 - 3,936,722 (-)NCBI
Rnor_6.0204,576,033 - 4,592,980 (+)NCBI
Rnor_5.0206,656,049 - 6,672,967 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006255959   ⟹   XP_006256021
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8203,924,263 - 3,941,238 (-)NCBI
mRatBN7.2203,919,623 - 3,936,728 (-)NCBI
Rnor_6.0204,576,033 - 4,592,980 (+)NCBI
Rnor_5.0206,656,049 - 6,672,967 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039098807   ⟹   XP_038954735
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8203,924,263 - 3,935,728 (-)NCBI
mRatBN7.2203,919,623 - 3,931,033 (-)NCBI
RefSeq Acc Id: XM_063279209   ⟹   XP_063135279
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8203,925,367 - 3,941,092 (-)NCBI
RefSeq Acc Id: XM_063279210   ⟹   XP_063135280
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8203,925,367 - 3,941,092 (-)NCBI
RefSeq Acc Id: XM_063279211   ⟹   XP_063135281
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8203,924,263 - 3,941,238 (-)NCBI
RefSeq Acc Id: NP_997628   ⟸   NM_212463
- UniProtKB: Q6MG72 (UniProtKB/TrEMBL),   F1M7S8 (UniProtKB/TrEMBL),   A0A8J8XWH8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256019   ⟸   XM_006255957
- Peptide Label: isoform X5
- UniProtKB: A0A8J8XWH8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256020   ⟸   XM_006255958
- Peptide Label: isoform X6
- UniProtKB: A0A0G2JZM5 (UniProtKB/TrEMBL),   A0A8J8XWH8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256021   ⟸   XM_006255959
- Peptide Label: isoform X9
- UniProtKB: A0A0G2JTA5 (UniProtKB/TrEMBL),   A0A8J8XWH8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256016   ⟸   XM_006255954
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006256017   ⟸   XM_006255955
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006256018   ⟸   XM_006255956
- Peptide Label: isoform X3
- Sequence:
Ensembl Acc Id: ENSRNOP00000074605   ⟸   ENSRNOT00000090125
Ensembl Acc Id: ENSRNOP00000071106   ⟸   ENSRNOT00000081456
Ensembl Acc Id: ENSRNOP00000068632   ⟸   ENSRNOT00000085701
Ensembl Acc Id: ENSRNOP00000042145   ⟸   ENSRNOT00000047370
RefSeq Acc Id: XP_038954735   ⟸   XM_039098807
- Peptide Label: isoform X10
RefSeq Acc Id: XP_063135281   ⟸   XM_063279211
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063135280   ⟸   XM_063279210
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063135279   ⟸   XM_063279209
- Peptide Label: isoform X4
Protein Domains
EHMT1/2 cysteine-rich region   Pre-SET   SET

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6MG72-F1-model_v2 AlphaFold Q6MG72 1-1263 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701360
Promoter ID:EPDNEW_R11882
Type:multiple initiation site
Name:Ehmt2_2
Description:euchromatic histone lysine methyltransferase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R11883  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0204,576,050 - 4,576,110EPDNEW
RGD ID:13701364
Promoter ID:EPDNEW_R11883
Type:multiple initiation site
Name:Ehmt2_1
Description:euchromatic histone lysine methyltransferase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R11882  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0204,576,530 - 4,576,590EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1302972 AgrOrtholog
BioCyc Gene G2FUF-4607 BioCyc
Ensembl Genes ENSRNOG00000030630 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000047370.6 UniProtKB/TrEMBL
  ENSRNOT00000081456.2 UniProtKB/TrEMBL
  ENSRNOT00000085701.2 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/TrEMBL
  2.170.270.10 UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  EHMT1/EHMT2 UniProtKB/TrEMBL
  EHMT2 UniProtKB/TrEMBL
  EHMT_ZBD UniProtKB/TrEMBL
  Pre-SET_dom UniProtKB/TrEMBL
  SET_dom UniProtKB/TrEMBL
  SET_dom_sf UniProtKB/TrEMBL
KEGG Report rno:361798 UniProtKB/TrEMBL
NCBI Gene 361798 ENTREZGENE
PANTHER PTHR46307 UniProtKB/TrEMBL
  PTHR46307:SF1 UniProtKB/TrEMBL
Pfam Ank UniProtKB/TrEMBL
  Ank_2 UniProtKB/TrEMBL
  EHMT1-2_CRR UniProtKB/TrEMBL
  Pre-SET UniProtKB/TrEMBL
  SET UniProtKB/TrEMBL
PhenoGen Ehmt2 PhenoGen
PRINTS ANKYRIN UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
  PRE_SET UniProtKB/TrEMBL
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
  SET UniProtKB/TrEMBL
RatGTEx ENSRNOG00000030630 RatGTEx
SMART ANK UniProtKB/TrEMBL
  PreSET UniProtKB/TrEMBL
  SET UniProtKB/TrEMBL
Superfamily-SCOP ANK UniProtKB/TrEMBL
  SSF82199 UniProtKB/TrEMBL
UniProt A0A0G2JTA5 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2JZM5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8J8XWH8 ENTREZGENE, UniProtKB/TrEMBL
  A6KTN1_RAT UniProtKB/TrEMBL
  A6KTN2_RAT UniProtKB/TrEMBL
  A6KTN3_RAT UniProtKB/TrEMBL
  A6KTN4_RAT UniProtKB/TrEMBL
  F1M7S8 ENTREZGENE
  Q6MG72 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F1M7S8 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-11 Ehmt2  euchromatic histone lysine methyltransferase 2  Ehmt2  euchromatic histone lysine N-methyltransferase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Ehmt2  euchromatic histone lysine N-methyltransferase 2      Symbol and Name updated 1299863 APPROVED
2005-02-14 Bat8  HLA-B associated transcript 8, rat orthologue      Symbol and Name status set to provisional 70820 PROVISIONAL