Ezh1 (enhancer of zeste 1 polycomb repressive complex 2 subunit) - Rat Genome Database

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Gene: Ezh1 (enhancer of zeste 1 polycomb repressive complex 2 subunit) Rattus norvegicus
Analyze
Symbol: Ezh1
Name: enhancer of zeste 1 polycomb repressive complex 2 subunit
RGD ID: 1305028
Description: Enables chromatin binding activity. Involved in hippocampus development and positive regulation of transcription by RNA polymerase II. Predicted to be located in chromosome, telomeric region; heterochromatin; and nucleoplasm. Predicted to be part of ESC/E(Z) complex. Predicted to be active in nucleus. Orthologous to human EZH1 (enhancer of zeste 1 polycomb repressive complex 2 subunit); PARTICIPATES IN histone modification pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: enhancer of zeste homolog 1; enhancer of zeste homolog 1 (Drosophila); histone-lysine N-methyltransferase EZH1; LOC303547
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,626,307 - 86,662,257 (-)NCBIGRCr8
mRatBN7.21086,126,023 - 86,162,001 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1086,126,015 - 86,161,921 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1091,162,463 - 91,188,804 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,641,259 - 90,667,579 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01086,034,424 - 86,060,744 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01089,104,026 - 89,139,978 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,104,027 - 89,130,339 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01088,902,522 - 88,938,413 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41090,211,249 - 90,237,563 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11090,227,546 - 90,252,203 (-)NCBI
Celera1084,843,423 - 84,869,785 (-)NCBICelera
Cytogenetic Map10q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Ezh1 and Ezh2 differentially regulate PSD-95 gene transcription in developing hippocampal neurons. Henriquez B, etal., Mol Cell Neurosci. 2013 Nov;57:130-43. doi: 10.1016/j.mcn.2013.07.012. Epub 2013 Aug 8.
4. SET for life: biochemical activities and biological functions of SET domain-containing proteins. Herz HM, etal., Trends Biochem Sci. 2013 Dec;38(12):621-39. doi: 10.1016/j.tibs.2013.09.004. Epub 2013 Oct 20.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Occupying chromatin: Polycomb mechanisms for getting to genomic targets, stopping transcriptional traffic, and staying put. Simon JA and Kingston RE, Mol Cell. 2013 Mar 7;49(5):808-24. doi: 10.1016/j.molcel.2013.02.013.
Additional References at PubMed
PMID:9214638   PMID:9584197   PMID:19026781   PMID:19303854   PMID:20064376   PMID:20075857   PMID:20144788   PMID:22438827   PMID:25477280   PMID:31451685  


Genomics

Comparative Map Data
Ezh1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,626,307 - 86,662,257 (-)NCBIGRCr8
mRatBN7.21086,126,023 - 86,162,001 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1086,126,015 - 86,161,921 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1091,162,463 - 91,188,804 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,641,259 - 90,667,579 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01086,034,424 - 86,060,744 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01089,104,026 - 89,139,978 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,104,027 - 89,130,339 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01088,902,522 - 88,938,413 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41090,211,249 - 90,237,563 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11090,227,546 - 90,252,203 (-)NCBI
Celera1084,843,423 - 84,869,785 (-)NCBICelera
Cytogenetic Map10q31NCBI
EZH1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381742,700,275 - 42,745,040 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1742,700,275 - 42,745,049 (-)EnsemblGRCh38hg38GRCh38
GRCh371740,852,293 - 40,897,058 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361738,105,819 - 38,150,574 (-)NCBINCBI36Build 36hg18NCBI36
Build 341738,105,819 - 38,150,574NCBI
Celera1737,507,762 - 37,552,422 (-)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1736,617,368 - 36,662,170 (-)NCBIHuRef
CHM1_11741,087,908 - 41,132,634 (-)NCBICHM1_1
T2T-CHM13v2.01743,557,412 - 43,602,180 (-)NCBIT2T-CHM13v2.0
Ezh1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911101,081,941 - 101,117,268 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11101,081,941 - 101,117,289 (-)EnsemblGRCm39 Ensembl
GRCm3811101,191,115 - 101,226,463 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11101,191,115 - 101,226,463 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711101,052,429 - 101,087,764 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611101,007,206 - 101,044,038 (-)NCBIMGSCv36mm8
Celera11112,487,231 - 112,522,681 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1164.37NCBI
Ezh1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545116,548,858 - 16,564,310 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545116,548,898 - 16,563,449 (-)NCBIChiLan1.0ChiLan1.0
EZH1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21922,240,711 - 22,285,877 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11724,130,797 - 24,175,862 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01714,572,868 - 14,618,012 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11714,814,061 - 14,842,295 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1714,814,054 - 14,842,295 (+)Ensemblpanpan1.1panPan2
EZH1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1920,271,729 - 20,292,918 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl920,264,552 - 20,290,712 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha919,724,769 - 19,754,876 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0920,981,842 - 21,011,945 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl920,981,878 - 21,011,945 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1919,767,995 - 19,797,890 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0920,032,956 - 20,063,052 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0920,136,953 - 20,167,063 (+)NCBIUU_Cfam_GSD_1.0
Ezh1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560219,609,211 - 19,644,761 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649017,428,677 - 17,465,877 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649017,430,383 - 17,465,889 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EZH1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1220,115,297 - 20,141,749 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11220,107,744 - 20,139,764 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21220,304,800 - 20,338,128 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EZH1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11663,544,483 - 63,592,651 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1663,558,551 - 63,587,501 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607734,337,734 - 34,385,777 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ezh1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247951,454,361 - 1,470,079 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ezh1
162 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:363
Count of miRNA genes:210
Interacting mature miRNAs:259
Transcripts:ENSRNOT00000027640
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108051528791230079Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108256485692369470Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)107877551698279596Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608594965338Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1064890616107211142Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)108402232193995963Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)107889965587307728Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108400727295933025Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108400727295933025Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1085565469103884409Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)107563188787055282Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat

Markers in Region
RH129834  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21086,126,064 - 86,126,262 (+)MAPPERmRatBN7.2
Rnor_6.01089,104,068 - 89,104,265NCBIRnor6.0
Rnor_5.01088,902,564 - 88,902,761UniSTSRnor5.0
RGSC_v3.41090,211,290 - 90,211,487UniSTSRGSC3.4
Celera1084,843,464 - 84,843,661UniSTS
RH 3.4 Map10877.1UniSTS
Cytogenetic Map10q32.1UniSTS
RH134861  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21086,133,121 - 86,133,313 (+)MAPPERmRatBN7.2
Rnor_6.01089,111,125 - 89,111,316NCBIRnor6.0
Rnor_5.01088,909,621 - 88,909,812UniSTSRnor5.0
RGSC_v3.41090,218,347 - 90,218,538UniSTSRGSC3.4
Celera1084,850,521 - 84,850,712UniSTS
RH 3.4 Map10877.1UniSTS
Cytogenetic Map10q32.1UniSTS
MARC_15753-15754:1017935735:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21086,128,774 - 86,129,586 (+)MAPPERmRatBN7.2
Rnor_6.01089,106,778 - 89,107,589NCBIRnor6.0
Rnor_5.01088,905,274 - 88,906,085UniSTSRnor5.0
RGSC_v3.41090,214,000 - 90,214,811UniSTSRGSC3.4
Celera1084,846,174 - 84,846,985UniSTS
Cytogenetic Map10q32.1UniSTS
BARC0021  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21086,129,533 - 86,130,016 (+)MAPPERmRatBN7.2
Rnor_6.01089,107,537 - 89,108,019NCBIRnor6.0
Rnor_5.01088,906,033 - 88,906,515UniSTSRnor5.0
RGSC_v3.41090,214,759 - 90,215,241UniSTSRGSC3.4
Celera1084,846,933 - 84,847,415UniSTS
Cytogenetic Map10q32.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000027640   ⟹   ENSRNOP00000027640
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1086,126,026 - 86,161,921 (-)Ensembl
Rnor_6.0 Ensembl1089,104,027 - 89,130,339 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101475   ⟹   ENSRNOP00000089467
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1086,126,015 - 86,161,917 (-)Ensembl
RefSeq Acc Id: NM_001107051   ⟹   NP_001100521
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,626,308 - 86,652,620 (-)NCBI
mRatBN7.21086,126,024 - 86,152,338 (-)NCBI
Rnor_6.01089,104,027 - 89,130,339 (-)NCBI
Rnor_5.01088,902,522 - 88,938,413 (-)NCBI
RGSC_v3.41090,211,249 - 90,237,563 (-)RGD
Celera1084,843,423 - 84,869,785 (-)RGD
Sequence:
RefSeq Acc Id: XM_006247318   ⟹   XP_006247380
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,626,307 - 86,662,257 (-)NCBI
mRatBN7.21086,126,023 - 86,162,001 (-)NCBI
Rnor_6.01089,104,026 - 89,139,978 (-)NCBI
Rnor_5.01088,902,522 - 88,938,413 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006247319   ⟹   XP_006247381
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,626,307 - 86,662,112 (-)NCBI
mRatBN7.21086,126,023 - 86,161,848 (-)NCBI
Rnor_6.01089,104,026 - 89,139,890 (-)NCBI
Rnor_5.01088,902,522 - 88,938,413 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008768052   ⟹   XP_008766274
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,626,307 - 86,662,240 (-)NCBI
mRatBN7.21086,126,023 - 86,162,001 (-)NCBI
Rnor_6.01089,104,026 - 89,139,978 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001100521 (Get FASTA)   NCBI Sequence Viewer  
  XP_006247380 (Get FASTA)   NCBI Sequence Viewer  
  XP_006247381 (Get FASTA)   NCBI Sequence Viewer  
  XP_008766274 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM06100 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000027640.7
  ENSRNOP00000089467.1
RefSeq Acc Id: NP_001100521   ⟸   NM_001107051
- UniProtKB: A6HJ95 (UniProtKB/TrEMBL),   F1LZH3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247380   ⟸   XM_006247318
- Peptide Label: isoform X1
- UniProtKB: F1LZH3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247381   ⟸   XM_006247319
- Peptide Label: isoform X1
- UniProtKB: F1LZH3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008766274   ⟸   XM_008768052
- Peptide Label: isoform X1
- UniProtKB: F1LZH3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000027640   ⟸   ENSRNOT00000027640
Ensembl Acc Id: ENSRNOP00000089467   ⟸   ENSRNOT00000101475
Protein Domains
CXC   SET

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LZH3-F1-model_v2 AlphaFold F1LZH3 1-747 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305028 AgrOrtholog
BioCyc Gene G2FUF-23193 BioCyc
Ensembl Genes ENSRNOG00000020336 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000027640.7 UniProtKB/TrEMBL
  ENSRNOT00000101475.1 UniProtKB/TrEMBL
Gene3D-CATH 2.170.270.10 UniProtKB/TrEMBL
InterPro CXC_dom UniProtKB/TrEMBL
  EZH1/2-like UniProtKB/TrEMBL
  EZH1/2_MCSS UniProtKB/TrEMBL
  EZH1_SET UniProtKB/TrEMBL
  EZH2_WD-Binding UniProtKB/TrEMBL
  PRC2_HTH_1 UniProtKB/TrEMBL
  Pre-SET_CXC UniProtKB/TrEMBL
  SANT_DNA-bd UniProtKB/TrEMBL
  SET_dom UniProtKB/TrEMBL
  SET_dom_sf UniProtKB/TrEMBL
  Tesmin/TSO1-like_CXC UniProtKB/TrEMBL
KEGG Report rno:303547 UniProtKB/TrEMBL
NCBI Gene 303547 ENTREZGENE
PANTHER PTHR45747 UniProtKB/TrEMBL
  PTHR45747:SF1 UniProtKB/TrEMBL
Pfam Ezh2_MCSS UniProtKB/TrEMBL
  EZH2_WD-Binding UniProtKB/TrEMBL
  PRC2_HTH_1 UniProtKB/TrEMBL
  preSET_CXC UniProtKB/TrEMBL
  SET UniProtKB/TrEMBL
PhenoGen Ezh1 PhenoGen
PROSITE CXC UniProtKB/TrEMBL
  SET UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020336 RatGTEx
SMART CXC UniProtKB/TrEMBL
  SANT UniProtKB/TrEMBL
  SET UniProtKB/TrEMBL
Superfamily-SCOP SSF82199 UniProtKB/TrEMBL
UniProt A0A8I6A7B9_RAT UniProtKB/TrEMBL
  A6HJ95 ENTREZGENE, UniProtKB/TrEMBL
  F1LZH3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-06-06 Ezh1  enhancer of zeste 1 polycomb repressive complex 2 subunit  Ezh1  enhancer of zeste homolog 1 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Ezh1  enhancer of zeste homolog 1 (Drosophila)   Ezh1_predicted  enhancer of zeste homolog 1 (Drosophila) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Ezh1_predicted  enhancer of zeste homolog 1 (Drosophila) (predicted)      Symbol and Name status set to approved 70820 APPROVED