Ehmt1 (euchromatic histone lysine methyltransferase 1) - Rat Genome Database

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Gene: Ehmt1 (euchromatic histone lysine methyltransferase 1) Rattus norvegicus
Analyze
Symbol: Ehmt1
Name: euchromatic histone lysine methyltransferase 1
RGD ID: 1307588
Description: Predicted to enable several functions, including C2H2 zinc finger domain binding activity; p53 binding activity; and protein-lysine N-methyltransferase activity. Involved in response to fungicide. Predicted to be located in chromatin and nuclear body. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Kleefstra syndrome and Kleefstra syndrome 1. Orthologous to human EHMT1 (euchromatic histone lysine methyltransferase 1); PARTICIPATES IN histone modification pathway; lysine degradation pathway; INTERACTS WITH 4-amino-2,6-dinitrotoluene; amphetamine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: euchromatic histone methyltransferase 1; euchromatic histone-lysine N-methyltransferase 1; histone-lysine N-methyltransferase EHMT1; histone-lysine N-methyltransferase EHMT1-like; histone-lysine N-methyltransferase, H3 lysine-9 specific 5; LOC100909589; LOC103691745; LOC362078; uncharacterized LOC103691745
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8327,978,888 - 28,127,178 (-)NCBIGRCr8
mRatBN7.237,580,680 - 7,729,046 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl37,580,683 - 7,729,007 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx310,684,555 - 10,777,264 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0319,270,788 - 19,363,493 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0317,460,616 - 17,553,324 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.031,966,974 - 2,123,858 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl31,960,957 - 2,123,820 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.031,951,004 - 2,106,608 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.433,074,136 - 3,169,921 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.133,074,159 - 3,225,936 (-)NCBI
Celera32,411,864 - 2,558,168 (-)NCBICelera
Cytogenetic Map3p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IBA)
nuclear body  (IEA,ISO)
nucleoplasm  (ISO)
nucleus  (IBA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Coexpression of nuclear receptors and histone methylation modifying genes in the testis: implications for endocrine disruptor modes of action. Anderson AM, etal., PLoS One. 2012;7(4):e34158. doi: 10.1371/journal.pone.0034158. Epub 2012 Apr 4.
2. Reduced exploration, increased anxiety, and altered social behavior: Autistic-like features of euchromatin histone methyltransferase 1 heterozygous knockout mice. Balemans MC, etal., Behav Brain Res. 2010 Mar 17;208(1):47-55. doi: 10.1016/j.bbr.2009.11.008. Epub 2009 Nov 5.
3. Histone lysine methylation dynamics: establishment, regulation, and biological impact. Black JC, etal., Mol Cell. 2012 Nov 30;48(4):491-507. doi: 10.1016/j.molcel.2012.11.006.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Analysis of EHMT1 expression and its correlations with clinical significance in esophageal squamous cell cancer. Guan X, etal., Mol Clin Oncol. 2014 Jan;2(1):76-80. Epub 2013 Oct 24.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Characterization of a novel transcript of the EHMT1 gene reveals important diagnostic implications for Kleefstra syndrome. Nillesen WM, etal., Hum Mutat. 2011 Jul;32(7):853-9. doi: 10.1002/humu.21523.
9. EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex. Ohno H, etal., Nature. 2013 Dec 5;504(7478):163-7. doi: 10.1038/nature12652. Epub 2013 Nov 6.
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. Kleefstra syndrome in three adult patients: further delineation of the behavioral and neurological phenotype shows aspects of a neurodegenerative course. Verhoeven WM, etal., Am J Med Genet A. 2011 Oct;155A(10):2409-15. doi: 10.1002/ajmg.a.34186. Epub 2011 Sep 9.
17. Overexpressions of G9a and MCM7 in Esophageal Squamous Cell Carcinoma Associated with Poor Prognosis. Zhong X, etal., Histopathology. 2014 May 7. doi: 10.1111/his.12456.
Additional References at PubMed
PMID:12004135   PMID:15774718   PMID:16702210   PMID:17392792   PMID:18818694   PMID:19144645   PMID:20118233   PMID:21131967   PMID:27893464   PMID:28665013   PMID:37839527  


Genomics

Comparative Map Data
Ehmt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8327,978,888 - 28,127,178 (-)NCBIGRCr8
mRatBN7.237,580,680 - 7,729,046 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl37,580,683 - 7,729,007 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx310,684,555 - 10,777,264 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0319,270,788 - 19,363,493 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0317,460,616 - 17,553,324 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.031,966,974 - 2,123,858 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl31,960,957 - 2,123,820 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.031,951,004 - 2,106,608 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.433,074,136 - 3,169,921 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.133,074,159 - 3,225,936 (-)NCBI
Celera32,411,864 - 2,558,168 (-)NCBICelera
Cytogenetic Map3p13NCBI
EHMT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389137,619,005 - 137,836,127 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9137,618,992 - 137,870,016 (+)EnsemblGRCh38hg38GRCh38
GRCh379140,513,457 - 140,730,579 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369139,725,238 - 139,850,400 (+)NCBINCBI36Build 36hg18NCBI36
Build 349137,881,253 - 138,006,413NCBI
Celera9111,130,415 - 111,256,878 (+)NCBICelera
Cytogenetic Map9q34.3NCBI
HuRef9109,975,406 - 110,193,755 (+)NCBIHuRef
CHM1_19140,662,174 - 140,878,710 (+)NCBICHM1_1
T2T-CHM13v2.09149,870,687 - 150,093,989 (+)NCBIT2T-CHM13v2.0
Ehmt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39224,680,781 - 24,809,658 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl224,679,940 - 24,809,626 (-)EnsemblGRCm39 Ensembl
GRCm38224,790,769 - 24,919,643 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl224,789,928 - 24,919,614 (-)EnsemblGRCm38mm10GRCm38
MGSCv37224,646,293 - 24,742,591 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36224,612,804 - 24,741,610 (-)NCBIMGSCv36mm8
Celera224,513,068 - 24,641,644 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map216.73NCBI
Ehmt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555135,547,313 - 5,641,499 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555135,491,446 - 5,642,559 (+)NCBIChiLan1.0ChiLan1.0
EHMT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2111,508,542 - 1,735,451 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan191,510,875 - 1,737,763 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09108,724,568 - 108,951,077 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19137,699,213 - 137,895,564 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9137,764,950 - 137,895,564 (+)Ensemblpanpan1.1panPan2
EHMT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1948,031,593 - 48,110,954 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl948,032,709 - 48,175,828 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha947,218,499 - 47,362,742 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0948,893,204 - 49,037,678 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl948,893,199 - 49,037,650 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1947,669,581 - 47,813,979 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0947,968,987 - 48,113,126 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0948,015,199 - 48,159,643 (-)NCBIUU_Cfam_GSD_1.0
Ehmt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947202,924,820 - 203,053,478 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936669321,249 - 423,018 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936669321,580 - 450,061 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EHMT1
(Sus scrofa - pig)		 No map positions available.
EHMT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.112380,041 - 545,333 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl12379,943 - 497,033 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660584,899,940 - 5,005,236 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ehmt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624760272,493 - 379,780 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624760271,397 - 463,462 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ehmt1
530 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:64
Count of miRNA genes:60
Interacting mature miRNAs:64
Transcripts:ENSRNOT00000066777
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat

Markers in Region
RH143167  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.237,624,480 - 7,624,666 (+)MAPPERmRatBN7.2
Rnor_6.032,011,556 - 2,011,741NCBIRnor6.0
Rnor_5.031,994,252 - 1,994,437UniSTSRnor5.0
RGSC_v3.433,120,906 - 3,121,091UniSTSRGSC3.4
Celera32,453,957 - 2,454,142UniSTS
Cytogenetic Map3p13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000066777   ⟹   ENSRNOP00000063511
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl37,580,684 - 7,673,289 (-)Ensembl
Rnor_6.0 Ensembl31,966,974 - 2,060,167 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000086843   ⟹   ENSRNOP00000074513
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl37,580,684 - 7,729,007 (-)Ensembl
Rnor_6.0 Ensembl31,960,957 - 2,123,820 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101650   ⟹   ENSRNOP00000089453
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl37,580,779 - 7,728,955 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104449   ⟹   ENSRNOP00000097763
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl37,580,683 - 7,673,683 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108139   ⟹   ENSRNOP00000090039
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl37,580,683 - 7,673,683 (-)Ensembl
RefSeq Acc Id: NM_001415867   ⟹   NP_001402796
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8327,978,888 - 28,127,126 (-)NCBI
mRatBN7.237,580,684 - 7,728,945 (-)NCBI
RefSeq Acc Id: NM_001415868   ⟹   NP_001402797
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8327,978,888 - 28,127,126 (-)NCBI
mRatBN7.237,580,684 - 7,728,945 (-)NCBI
RefSeq Acc Id: XM_006233619   ⟹   XP_006233681
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8327,978,888 - 28,127,175 (-)NCBI
mRatBN7.237,580,680 - 7,729,002 (-)NCBI
Rnor_6.031,966,975 - 2,123,853 (-)NCBI
Rnor_5.031,951,004 - 2,106,608 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017591872   ⟹   XP_017447361
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8327,978,888 - 28,127,178 (-)NCBI
mRatBN7.237,580,680 - 7,729,046 (-)NCBI
Rnor_6.031,966,975 - 2,123,858 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017591873   ⟹   XP_017447362
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8327,978,888 - 28,127,178 (-)NCBI
mRatBN7.237,580,680 - 7,729,046 (-)NCBI
Rnor_6.031,966,975 - 2,123,858 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039105343   ⟹   XP_038961271
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8327,978,888 - 28,127,051 (-)NCBI
mRatBN7.237,580,680 - 7,728,881 (-)NCBI
RefSeq Acc Id: XM_039105344   ⟹   XP_038961272
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8327,978,888 - 28,127,108 (-)NCBI
mRatBN7.237,580,680 - 7,728,921 (-)NCBI
RefSeq Acc Id: XM_063284053   ⟹   XP_063140123
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8327,978,888 - 28,127,175 (-)NCBI
RefSeq Acc Id: XM_063284054   ⟹   XP_063140124
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8327,978,888 - 28,127,178 (-)NCBI
RefSeq Acc Id: XM_063284055   ⟹   XP_063140125
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8327,978,888 - 28,127,178 (-)NCBI
RefSeq Acc Id: XR_010064648
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8327,992,964 - 28,127,178 (-)NCBI
RefSeq Acc Id: XP_006233681   ⟸   XM_006233619
- Peptide Label: isoform X1
- UniProtKB: D4A005 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447362   ⟸   XM_017591873
- Peptide Label: isoform X6
- UniProtKB: D4A005 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447361   ⟸   XM_017591872
- Peptide Label: isoform X5
- UniProtKB: D4A005 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074513   ⟸   ENSRNOT00000086843
Ensembl Acc Id: ENSRNOP00000063511   ⟸   ENSRNOT00000066777
RefSeq Acc Id: XP_038961272   ⟸   XM_039105344
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038961271   ⟸   XM_039105343
- Peptide Label: isoform X7
- UniProtKB: D4A005 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000090039   ⟸   ENSRNOT00000108139
Ensembl Acc Id: ENSRNOP00000097763   ⟸   ENSRNOT00000104449
Ensembl Acc Id: ENSRNOP00000089453   ⟸   ENSRNOT00000101650
RefSeq Acc Id: NP_001402796   ⟸   NM_001415867
- Peptide Label: isoform 1
RefSeq Acc Id: NP_001402797   ⟸   NM_001415868
- Peptide Label: isoform 2
RefSeq Acc Id: XP_063140125   ⟸   XM_063284055
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063140124   ⟸   XM_063284054
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063140123   ⟸   XM_063284053
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K889 (UniProtKB/TrEMBL)
Protein Domains
Pre-SET   SET

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K889-F1-model_v2 AlphaFold A0A0G2K889 1-1289 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691856
Promoter ID:EPDNEW_R2376
Type:multiple initiation site
Name:Ehmt1_1
Description:euchromatic histone lysine methyltransferase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.032,123,814 - 2,123,874EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307588 AgrOrtholog
BioCyc Gene G2FUF-50498 BioCyc
Ensembl Genes ENSRNOG00000007242 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000066777.4 UniProtKB/TrEMBL
  ENSRNOT00000086843.2 UniProtKB/TrEMBL
  ENSRNOT00000101650.1 UniProtKB/TrEMBL
  ENSRNOT00000104449.1 UniProtKB/TrEMBL
  ENSRNOT00000108139.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/TrEMBL
  2.170.270.10 UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  EHMT1 UniProtKB/TrEMBL
  EHMT1/EHMT2 UniProtKB/TrEMBL
  EHMT_ZBD UniProtKB/TrEMBL
  Pre-SET_dom UniProtKB/TrEMBL
  SET_dom UniProtKB/TrEMBL
  SET_dom_sf UniProtKB/TrEMBL
NCBI Gene 362078 ENTREZGENE
PANTHER PTHR46307 UniProtKB/TrEMBL
  PTHR46307:SF2 UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/TrEMBL
  Ank_4 UniProtKB/TrEMBL
  EHMT1-2_CRR UniProtKB/TrEMBL
  Pre-SET UniProtKB/TrEMBL
  SET UniProtKB/TrEMBL
PhenoGen Ehmt1 PhenoGen
PRINTS ANKYRIN UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
  PRE_SET UniProtKB/TrEMBL
  SET UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007242 RatGTEx
SMART ANK UniProtKB/TrEMBL
  PreSET UniProtKB/TrEMBL
  SET UniProtKB/TrEMBL
Superfamily-SCOP ANK UniProtKB/TrEMBL
  SSF82199 UniProtKB/TrEMBL
UniProt A0A0G2K889 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AB09_RAT UniProtKB/TrEMBL
  A0A8I6ABS0_RAT UniProtKB/TrEMBL
  A0A8I6ANQ0_RAT UniProtKB/TrEMBL
  D4A005 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Ehmt1  euchromatic histone lysine methyltransferase 1  LOC103691745  uncharacterized LOC103691745  Data merged from RGD:9314471 737654 PROVISIONAL
2016-05-11 Ehmt1  euchromatic histone lysine methyltransferase 1  Ehmt1  euchromatic histone-lysine N-methyltransferase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-07-29 LOC103691745  uncharacterized LOC103691745  LOC100909589  histone-lysine N-methyltransferase EHMT1-like  Data merged from RGD:6503168 737654 PROVISIONAL
2014-08-25 LOC103691745  uncharacterized LOC103691745      Symbol and Name status set to provisional 70820 PROVISIONAL
2012-07-05 LOC100909589  histone-lysine N-methyltransferase EHMT1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-11-14 Ehmt1  euchromatic histone-lysine N-methyltransferase 1  Ehmt1  euchromatic histone methyltransferase 1   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Ehmt1  euchromatic histone methyltransferase 1   Ehmt1_predicted  euchromatic histone methyltransferase 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Ehmt1_predicted  euchromatic histone methyltransferase 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED