Rasa4 (RAS p21 protein activator 4)

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Gene: Rasa4 (RAS p21 protein activator 4) Rattus norvegicus

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Symbol:

Rasa4

Name:

RAS p21 protein activator 4

RGD ID:

1565457

Description:

Predicted to enable GTPase activator activity; metal ion binding activity; and phospholipid binding activity. Predicted to be involved in cellular response to calcium ion; intracellular signal transduction; and negative regulation of Ras protein signal transduction. Orthologous to several human genes including RASA4B (RAS p21 protein activator 4B); INTERACTS WITH acrylamide (ortholog); aristolochic acid A (ortholog); bisphenol A (ortholog).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

calcium-promoted RAS inactivator; Capri; LOC288589; ras GTPase-activating protein 4; ras GTPase-activating protein 4B; RGD1565457; similar to Rasa4 protein

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RASA4B (RAS p21 protein activator 4B)	HGNC	EggNOG, Ensembl, Inparanoid, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Rasa4 (RAS p21 protein activator 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Rasa4b (RAS p21 protein activator 4B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RASA4B (RAS p21 protein activator 4B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Rasa4b (RAS p21 protein activator 4B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RASA4B (RAS p21 protein activator 4B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	RASA4B (RAS p21 protein activator 4B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rasa4b (RAS p21 protein activator 4B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	RASA4 (RAS p21 protein activator 4)	HGNC	Ensembl, HomoloGene, NCBI, OrthoDB, Panther, Treefam
Homo sapiens (human):	ZDHHC4 (zinc finger DHHC-type palmitoyltransferase 4)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	RASA4 (RAS p21 protein activator 4)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Rasa4 (RAS p21 protein activator 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	RASA4B (RAS p21 protein activator 4B)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	rasa4 (RAS p21 protein activator 4)	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	gap-1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	rasa4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	26,189,416 - 26,216,801 (-)	NCBI		GRCr8
mRatBN7.2	12	20,552,805 - 20,580,177 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	20,552,806 - 20,580,147 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	12	23,596,989 - 23,624,386 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	23,596,981 - 23,624,316 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	25,597,339 - 25,624,728 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	21,668,173 - 21,695,505 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	12	22,321,187 - 22,348,572 (-)	NCBI		Celera
Cytogenetic Map	12	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

pleomorphic xanthoastrocytoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

acrylamide (ISO)

aristolochic acid A (ISO)

bisphenol A (ISO)

doxorubicin (ISO)

fulvestrant (ISO)

glyphosate (ISO)

niclosamide (ISO)

sotorasib (ISO)

trametinib (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to calcium ion (IEA)

intracellular signal transduction (IEA)

negative regulation of Ras protein signal transduction (IEA)

Molecular Function

GTPase activator activity (IEA)

metal ion binding (IEA)

phospholipid binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:15632090	PMID:16815298

Genomics

Comparative Map Data

Rasa4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	26,189,416 - 26,216,801 (-)	NCBI		GRCr8
mRatBN7.2	12	20,552,805 - 20,580,177 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	20,552,806 - 20,580,147 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	12	23,596,989 - 23,624,386 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	23,596,981 - 23,624,316 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	25,597,339 - 25,624,728 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	21,668,173 - 21,695,505 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	12	22,321,187 - 22,348,572 (-)	NCBI		Celera
Cytogenetic Map	12	q12	NCBI

RASA4B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	102,479,976 - 102,517,777 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	102,479,976 - 102,517,777 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	102,120,423 - 102,158,224 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Cytogenetic Map	7	q22.1	NCBI
CHM1_1	7	102,053,635 - 102,088,196 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	7	103,797,581 - 103,835,325 (-)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	101,483,887 - 101,518,525 (-)	NCBI

Rasa4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	136,112,775 - 136,140,714 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	136,112,770 - 136,140,714 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	136,083,916 - 136,111,860 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	136,083,916 - 136,111,860 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	136,559,786 - 136,587,730 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	136,368,543 - 136,396,487 (+)	NCBI		MGSCv36	mm8
Celera	5	133,104,290 - 133,132,214 (+)	NCBI		Celera
Cytogenetic Map	5	G2	NCBI
cM Map	5	75.76	NCBI

Rasa4b
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955456	15,114,525 - 15,143,493 (+)	NCBI	ChiLan1.0	ChiLan1.0

RASA4B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	7,683,101 - 7,705,994 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	9,378,179 - 9,401,012 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	7,503,229 - 7,526,168 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	7,502,769 - 7,526,180 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	7,471,860 - 7,494,678 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	7,434,857 - 7,457,744 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	7,598,480 - 7,621,454 (+)	NCBI		UU_Cfam_GSD_1.0

Rasa4b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	132,107,500 - 132,133,573 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936543	1,902,957 - 1,929,023 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RASA4B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	3	9,816,576 - 9,846,340 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	9,665,836 - 9,695,479 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RASA4B
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	28	10,714,179 - 10,736,172 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666070	5,670,806 - 5,708,708 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rasa4b
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624740	15,139,294 - 15,171,451 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Rasa4
169 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	179
Count of miRNA genes:	99
Interacting mature miRNAs:	111
Transcripts:	ENSRNOT00000001943, ENSRNOT00000064405
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631560	Apr1	Acute phase response QTL 1	6.1		orosomucoid 1 amount (VT:0010541)	plasma orosomucoid 1 level (CMO:0001467)	12	19144362	46669029	Rat
61443	Btemp2	Thermal response to stress QTL 2	3.3	0.000094	body temperature trait (VT:0005535)	core body temperature (CMO:0001036)	12	15025183	20794014	Rat
8552964	Pigfal17	Plasma insulin-like growth factor 1 level QTL 17	3.5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	5564495	46669029	Rat
61324	Eae5	Experimental allergic encephalomyelitis QTL 5	14		nervous system integrity trait (VT:0010566)	percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)	12	19610870	46669029	Rat
9590147	Scort7	Serum corticosterone level QTL 7	13.61	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	12	1	42110980	Rat
1549829	Scl48	Serum cholesterol level QTL 48	5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	12	9603277	46669029	Rat
61331	Eau2	Experimental allergic uveoretinitis QTL 2		0.0005	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	12	8525423	28064601	Rat
737822	Alc10	Alcohol consumption QTL 10	2.2		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	12	19610870	40218516	Rat
2293684	Bmd26	Bone mineral density QTL 26	4.4	0.0002	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	12	15872653	32974238	Rat
6893681	Bw109	Body weight QTL 109	2.3	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	12	1	23297788	Rat
1302792	Scl21	Serum cholesterol level QTL 21	3.8	0.0011	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	12	7196730	46669029	Rat
1598855	Bp294	Blood pressure QTL 294	3.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	1	34851688	Rat
10755457	Coatc14	Coat color QTL 14		0.01759	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	12	1	22591684	Rat
1331761	Bp218	Blood pressure QTL 218	2.973		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	11073825	45055165	Rat
8694179	Bw150	Body weight QTL 150	2.9	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	12	1	42110980	Rat
7411545	Bw128	Body weight QTL 128	5.2	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	12	1	42110980	Rat
7411547	Bw129	Body weight QTL 129		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	5564495	46669029	Rat
1300157	Rf21	Renal function QTL 21	4.4		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	12	9318216	32103380	Rat
737979	Pia22	Pristane induced arthritis QTL 22	53.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	1	44465750	Rat
1298081	Cia25	Collagen induced arthritis QTL 25	4.7		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	19610889	35682913	Rat
2300186	Bmd59	Bone mineral density QTL 59	7.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	12	10474137	46669029	Rat
7411660	Foco28	Food consumption QTL 28	10.9	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
1331755	Bp219	Blood pressure QTL 219	3.041		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	11073825	28064557	Rat
70213	Niddm27	Non-insulin dependent diabetes mellitus QTL 27	3.72		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	19835789	38193007	Rat
2306789	Ean6	Experimental allergic neuritis QTL 6	4.9		nervous system integrity trait (VT:0010566)	experimental autoimmune neuritis severity score (CMO:0001528)	12	19610870	24139202	Rat
7411641	Foco19	Food consumption QTL 19	27.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	5564495	46669029	Rat
7411643	Foco20	Food consumption QTL 20		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	20328819	46669029	Rat
5684888	Pia42	Pristane induced arthritis QTL 42			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	19610870	42828880	Rat
1549912	Bp268	Blood pressure QTL 268			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	10	13182736	46669029	Rat
2302060	Pia37	Pristane induced arthritis QTL 37	6.1	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	12	13198157	46669029	Rat
1641928	Alcrsp5	Alcohol response QTL 5			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	12	12812385	46669029	Rat
8552912	Pigfal6	Plasma insulin-like growth factor 1 level QTL 6	5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	5564498	46669029	Rat
10059594	Kidm46	Kidney mass QTL 46	3.79	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	12	6107579	46669029	Rat
1581516	Cm56	Cardiac mass QTL 56	4.2	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	12	1	29333307	Rat
9590086	Insglur6	Insulin/glucose ratio QTL 6	18.97	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	12	1	42110980	Rat
8552918	Pigfal7	Plasma insulin-like growth factor 1 level QTL 7			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	5564495	46669029	Rat
1549902	Bp269	Blood pressure QTL 269			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	13182736	46669029	Rat
61404	Bw120	Body weight QTL 120	5.1		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	12	12351619	46669029	Rat
1331786	Kidm11	Kidney mass QTL 11	3.571		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	12	11073825	24234895	Rat
2293699	Bss49	Bone structure and strength QTL 49	5.61	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	12	10474137	46669029	Rat
634351	Apr5	Acute phase response QTL 5	6.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	12	1	44503507	Rat
634350	Apr4	Acute phase response QTL 4	6		orosomucoid 1 amount (VT:0010541)	plasma orosomucoid 1 level (CMO:0001467)	12	1172005	46172005	Rat
61416	Pia4	Pristane induced arthritis QTL 4	8.4		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	12	13635523	30827399	Rat
631521	Pia12	Pristane induced arthritis QTL 12	8.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	20259417	23672083	Rat
7387292	Kidm42	Kidney mass QTL 42	3.03	0.0004	kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	12	1	36247923	Rat
61421	Cia12	Collagen induced arthritis QTL 12	4.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	13635523	35682913	Rat
2303569	Gluco44	Glucose level QTL 44	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	12812385	46669029	Rat
7411586	Foco5	Food consumption QTL 5	5.4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
2303575	Insul14	Insulin level QTL 14	4		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	12	1	42450532	Rat
7411588	Foco6	Food consumption QTL 6		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	5564495	46669029	Rat
2302042	Pia38	Pristane induced arthritis QTL 38	3.5	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	12	1	44503507	Rat
7411595	Foco9	Food consumption QTL 9	4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
7411597	Foco10	Food consumption QTL 10		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	5564495	46669029	Rat
2293086	Iddm30	Insulin dependent diabetes mellitus QTL 30	3.82		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	8449490	28302290	Rat
631543	Bp83	Blood pressure QTL 83	5.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	15550826	38478808	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001432268	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001432269	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001432270	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001432271	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_002724809	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_002727953	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039090070	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC091617	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473973	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000001943 ⟹ ENSRNOP00000001943

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	20,552,806 - 20,580,147 (-)	Ensembl
Rnor_6.0 Ensembl	12	23,596,981 - 23,624,316 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000064405 ⟹ ENSRNOP00000061084

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	20,552,806 - 20,580,147 (-)	Ensembl
Rnor_6.0 Ensembl	12	23,597,267 - 23,624,212 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000114942 ⟹ ENSRNOP00000096534

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	20,552,806 - 20,580,147 (-)	Ensembl

RefSeq Acc Id:

XM_002727953 ⟹ XP_002727999

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	26,189,416 - 26,216,801 (-)	NCBI
mRatBN7.2	12	20,552,805 - 20,580,177 (-)	NCBI
Rnor_6.0	12	23,596,989 - 23,624,386 (-)	NCBI
Rnor_5.0	12	25,597,339 - 25,624,728 (-)	NCBI
RGSC_v3.4	12	21,668,173 - 21,695,505 (-)	RGD

Sequence:

show sequence

CGAGGGGCGGGGAGGGGTGAATGGAGTAGCGGAGATCCCTCCGCCCCAGCGCTCCCCTCTCTGG
CCTCCGCACCCGCCTGCTTGCAGCGCCACTCTCACTGCCCCCTCCCACTCTCGGGAGGGGACCC
AGGCGTCCGAACCGCTCCCTACAGGCCTCCACGTCGCCGACCCGCAATGGCCAAGCGCAGTTCG
CTGTCCATCCGAATCGTAGAAGGGAAAAATCTGCCCGCCAAGGACATCACGGGCAGCAGCGACC
CCTACTGCATCGTGAAGGTGGACAATGAACCAATCATCAGGACAGCCACTGTGTGGAAGACCCT
GTGCCCATTCTGGGGTGAAGAGTACCAAGTACATTTACCCCCCACATTCCACATGGTGGCCTTC
TATGTTATGGATGAAGACGCCCTTAGCCGGGACGATGTGATCGGGAAGGTCTGCCTCACAAGGG
ATGAGCTAACCTCTCACCCAAAGGGATTCATCGGATGGACCCACCTGGTGGAGGTGGACCCGAA
CGAGGAGGTGCAGGGTGAGATCCACCTGCGTCTGGAGGTGGTGCCAGGGCTCCACGCCAGCCGG
CTGCGCTGCTCTGTGCTTGAGGCCAGGGACTTAGCACCAAAAGACCGGAATGGCGCATCTGACC
CTTTTGTCCGAGTGCACTACAATGGCCGGACCCAGGAGACCTCGGTGGTGAAAAAATCCTGCTA
CCCACGCTGGAATGAGACATTTGAGTTTGAGCTGGAAAAGGGAGCCACAGAAGCACTGCTGGTG
GAGGCCTGGGACTGGGATCTTGTTAGCCGGAATGACTTTCTAGGCAAAGTGGTAGTCAATGTCC
AGACACTGTGTTCAGCCCAGCAGGAAGAGGGCTGGTTCCGGCTGCAGCCCGACCAGTCCAAAAG
CCGTCAAGGCAAGGGCAACCTGGGCTCCTTGCAGTTGGAGGTGCGGCTGCGGGATGAGACAGTG
CTGCCGTCTGTCTACTACCAGCCTCTGGTACAGCTGCTGTGCCAGGAGGTGAAGCTGGGCACCC
AGGGCCCAGGACAGCTGATTCCTGTCATTGAGGAGACAACCAGTGCTGAGTGTCGCCAGGAAGT
GGCCACCACCCTGCTTAAGCTCTTCCTGGGGCAGGGGCTGGCCAAGGACCTTCTGGACCTGCTC
TTTCAGCTGGAGCTGGGCCGCACCAGTGAGGCCAACACCCTCTTCCGGAGCAATTCTCTGGCCT
CAAAGTCCATGGAATCCTTTCTGAAGGTGGCAGGGATGCGCTATCTGCATGGCATCCTGGGCCC
CATCATTGACAGAGTGTTCGAGGAGAAGAAGTATGTGGAGCTGGACCCCAGCAAAGTGGAAGTT
AAGGATGTAGGGTGCTCTGGGCTGCACCGCCCACAGACGGAGGCTGAAGTGTTAGAGCAGAGCG
CACAGACGCTGCGTGCCCACTTGGTGGCGCTGCTGAGCGCCATATGCCGCTCGGTTCGCACCTG
TCCAGCTGTGGTCCGCGCCACTTTTCGGCAGCTGTTCAGGCGCGTGCGGGAGCGCTTCCCCAGC
GCCCAGCATCAGAACGTACCATTCATCGCGGTCACCAGCTTCCTGTGCCTGCGCTTCTTCTCTC
CCGCCATCCTGTCGCCCAAGCTCTTCCACCTGCGAGAGCGGCATGCAGATGCTCGCACCAGTCG
CACACTACTTCTGCTGGCCAAGGCGGTCCAGAACATAGGCAATATGGACACACCGGTCTCCAGG
GCCAAAGAGTCGTGGATGGAACCACTACAGCCTACTGTGCGCCAGGGTGTGGTGCAGCTGAAGG
ACTTCATTACGAAGCTCGTGGACATAGAAGAAAAGGAAGAGCTGGACCTGCAGCGGGCATTGAA
CTTGCAGGCTCCGCCTGTGAAGGAGGGACCACTGTTTATCCACAGAACCAAAGGCAAAGGCCCT
CTTGCGTCCTCCTCGTTCAAGAAACTCTACTTCTCTCTTACCACTGAAGCCCTCAGCTTCGCCA
AGACATCCAGCTCCAAGAAAAGTGTCTTCATCAAGCTGGCCAGCATCCGGGCTGCGGAGAAGGT
GGAGGAAAAGAGCTTCGGCAGCTCCCACGTCATGCAGGTCATCTACTCAGACGATGTTGGCCGG
GCCCAGACTGTCTACCTGCAGTGCAAGTGTGTGAACGAGTTGAACCAGTGGCTATCTGCACTGC
GCAAAGTGATTACCAACAATGCCAGCCTCCTGGGCTCCTACCACCCTGGCGTCTTCCGTGGGGA
CAAGTGGAGCTGCTGTCACCAGAAGGAAAAGACAGATCTGGGATGTGACAAGACCCATTCTCGG
GTGACCCTGCAGGAGTGGAATGACCCACTGGACCATGACCTTGAGGCGCAGCTCATCTACAGAC
ACCTGCTAGGAGTAGAGGCTGCTCTTCGGGAAAAGCACCAGCTCCTGAGCCGGGCAACAGAAGA
AGCAGGCACCTCATCCACAGGCCGTGGCGGAGCTCCTGAGGACTCACTGGCCCAGCTGCTCCGA
GTGCTGCGAGACCTTCGAGAAGCCCACAGCTCCAGCCTGGCTAGCTCGCCATCCAGAGAGCCCC
GTCACCTCCTAGAGCTACAGACATGAGGTGTCCGTGAGGCGTCCACTGAGCCTGTCAGGTGTCT
GGAGATCCTTAACGTGCTCAGGACCCTGTCCCAGTCAACTGTTCTGGGGAGGGTTGTGACTCAA
CATGGTCTTCTCCATGTCTTTGTGGGACAACTGTGGCACCTGCTTCTTTGGGAGACCCGACTAT
TCCTGCAGTCCCTGTGGCCCAGATCCTTCACCCAGGAGACCAGGCTGTCCACCTCACACTGCTT
TGCCACTGTCTGGCTTCCTAGGTCATTAATAAACCTGCTGTGACTGCT

hide sequence

RefSeq Acc Id:

XM_039090070 ⟹ XP_038945998

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	26,189,416 - 26,200,171 (-)	NCBI
mRatBN7.2	12	20,552,805 - 20,563,567 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001419197	(Get FASTA)	NCBI Sequence Viewer
	NP_001419198	(Get FASTA)	NCBI Sequence Viewer
	NP_001419199	(Get FASTA)	NCBI Sequence Viewer
	NP_001419200	(Get FASTA)	NCBI Sequence Viewer
	XP_002727999	(Get FASTA)	NCBI Sequence Viewer
	XP_038945998	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM13325	(Get FASTA)	NCBI Sequence Viewer
	EDM13326	(Get FASTA)	NCBI Sequence Viewer
	EDM13327	(Get FASTA)	NCBI Sequence Viewer
	EDM13328	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000001943.5
	ENSRNOP00000061084.1
	ENSRNOP00000096534.1

RefSeq Acc Id:

XP_002727999 ⟸ XM_002727953

- Peptide Label:

isoform X1

- Sequence:

show sequence

MAKRSSLSIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPT
FHMVAFYVMDEDALSRDDVIGKVCLTRDELTSHPKGFIGWTHLVEVDPNEEVQGEIHLRLEVVP
GLHASRLRCSVLEARDLAPKDRNGASDPFVRVHYNGRTQETSVVKKSCYPRWNETFEFELEKGA
TEALLVEAWDWDLVSRNDFLGKVVVNVQTLCSAQQEEGWFRLQPDQSKSRQGKGNLGSLQLEVR
LRDETVLPSVYYQPLVQLLCQEVKLGTQGPGQLIPVIEETTSAECRQEVATTLLKLFLGQGLAK
DLLDLLFQLELGRTSEANTLFRSNSLASKSMESFLKVAGMRYLHGILGPIIDRVFEEKKYVELD
PSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLVALLSAICRSVRTCPAVVRATFRQLFRRV
RERFPSAQHQNVPFIAVTSFLCLRFFSPAILSPKLFHLRERHADARTSRTLLLLAKAVQNIGNM
DTPVSRAKESWMEPLQPTVRQGVVQLKDFITKLVDIEEKEELDLQRALNLQAPPVKEGPLFIHR
TKGKGPLASSSFKKLYFSLTTEALSFAKTSSSKKSVFIKLASIRAAEKVEEKSFGSSHVMQVIY
SDDVGRAQTVYLQCKCVNELNQWLSALRKVITNNASLLGSYHPGVFRGDKWSCCHQKEKTDLGC
DKTHSRVTLQEWNDPLDHDLEAQLIYRHLLGVEAALREKHQLLSRATEEAGTSSTGRGGAPEDS
LAQLLRVLRDLREAHSSSLASSPSREPRHLLELQT

hide sequence

Ensembl Acc Id:

ENSRNOP00000001943 ⟸ ENSRNOT00000001943

Ensembl Acc Id:

ENSRNOP00000061084 ⟸ ENSRNOT00000064405

RefSeq Acc Id:	XP_038945998 ⟸ XM_039090070
- Peptide Label:	isoform X2

Ensembl Acc Id:

ENSRNOP00000096534 ⟸ ENSRNOT00000114942

Protein Domains

C2 PH Ras-GAP

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZQH9-F1-model_v2	AlphaFold	D3ZQH9	1-803	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698542

Promoter ID:

EPDNEW_R9065

Type:

single initiation site

Name:

Rasa4_1

Description:

RAS p21 protein activator 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	12	23,624,336 - 23,624,396	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1565457	AgrOrtholog
BioCyc Gene	G2FUF-19652	BioCyc
Ensembl Genes	ENSRNOG00000001431	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000001943.9	UniProtKB/TrEMBL
	ENSRNOT00000064405.3	UniProtKB/TrEMBL
	ENSRNOT00000114942.1	UniProtKB/TrEMBL
Gene3D-CATH	2.30.29.30	UniProtKB/TrEMBL
	2.60.40.150	UniProtKB/TrEMBL
InterPro	C2_Ca-dep	UniProtKB/TrEMBL
	C2_domain_sf	UniProtKB/TrEMBL
	PH_type	UniProtKB/TrEMBL
	Pleckstrin_homology	UniProtKB/TrEMBL
	Ras_GTPase	UniProtKB/TrEMBL
	RASA4_PH	UniProtKB/TrEMBL
	RasGAP	UniProtKB/TrEMBL
	RasGAP_CS	UniProtKB/TrEMBL
	Rho_GTPase_activation_prot	UniProtKB/TrEMBL
	Znf_Btk_motif	UniProtKB/TrEMBL
KEGG Report	rno:288589	UniProtKB/TrEMBL
NCBI Gene	288589	ENTREZGENE
PANTHER	PTHR10194	UniProtKB/TrEMBL
	RAS GTPASE-ACTIVATING PROTEIN 4-RELATED	UniProtKB/TrEMBL
Pfam	BTK	UniProtKB/TrEMBL
	PF00168	UniProtKB/TrEMBL
	PF00169	UniProtKB/TrEMBL
	RasGAP	UniProtKB/TrEMBL
PhenoGen	Rasa4	PhenoGen
PRINTS	C2DOMAIN	UniProtKB/TrEMBL
PROSITE	PH_DOMAIN	UniProtKB/TrEMBL
	PS50004	UniProtKB/TrEMBL
	RAS_GTPASE_ACTIV_1	UniProtKB/TrEMBL
	RAS_GTPASE_ACTIV_2	UniProtKB/TrEMBL
	ZF_BTK	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000001431	RatGTEx
SMART	BTK	UniProtKB/TrEMBL
	RasGAP	UniProtKB/TrEMBL
	SM00233	UniProtKB/TrEMBL
	SM00239	UniProtKB/TrEMBL
Superfamily-SCOP	PH domain-like	UniProtKB/TrEMBL
	Rho_GAP	UniProtKB/TrEMBL
	SSF49562	UniProtKB/TrEMBL
UniProt	A0A8I6GM45_RAT	UniProtKB/TrEMBL
	A6J086	ENTREZGENE, UniProtKB/TrEMBL
	A6J088	ENTREZGENE, UniProtKB/TrEMBL
	D3ZQH9	ENTREZGENE, UniProtKB/TrEMBL
	D4A166_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2010-11-12	Rasa4	RAS p21 protein activator 4	RGD1565457	similar to Rasa4 protein	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	RGD1565457	similar to Rasa4 protein	RGD1565457_predicted	similar to Rasa4 protein (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-07	RGD1565457_predicted	similar to Rasa4 protein (predicted)	LOC288589	similar to Rasa4 protein	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC288589	similar to Rasa4 protein			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar