Suv39h1-ps1 (SUV39H1 histone lysine methyltransferase, pseudogene 1) - Rat Genome Database

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Gene: Suv39h1-ps1 (SUV39H1 histone lysine methyltransferase, pseudogene 1) Rattus norvegicus
Analyze
Symbol: Suv39h1-ps1
Name: SUV39H1 histone lysine methyltransferase, pseudogene 1
RGD ID: 1565692
Description: Predicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; histone H3K9 trimethyltransferase activity; and histone H3K9me2 methyltransferase activity. Predicted to be involved in several processes, including cellular response to glucose starvation; energy homeostasis; and regulation of gene expression. Predicted to act upstream of or within several processes, including blastocyst hatching; determination of adult lifespan; and regulation of nucleobase-containing compound metabolic process. Predicted to be located in nucleolus and rDNA heterochromatin. Predicted to be part of eNoSc complex. Predicted to be active in nucleus. Orthologous to human SUV39H1 (SUV39H1 histone lysine methyltransferase); PARTICIPATES IN histone modification pathway; methionine cycle/metabolic pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: pseudo
RefSeq Status: INFERRED
Previously known as: histone-lysine N-methyltransferase SUV39H1-like; LOC501653; RGD1565692; similar to Su(var)3-9 homolog; suppressor of variegation 3-9 homolog 1; suppressor of variegation 3-9 homolog 1 (Drosophila); Suv39h1; SUV39H1 histone lysine methyltransferase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Functional Gene: Suv39h1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X146,828,818 - 146,831,485 (-)NCBIGRCr8
mRatBN7.2X141,792,589 - 141,795,257 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_UtxX143,977,956 - 143,980,623 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X147,518,936 - 147,521,604 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X145,074,611 - 145,077,279 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X146,532,002 - 146,533,538 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X146,551,234 - 146,555,970 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X149,153,769 - 149,155,266 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX137,768,982 - 137,770,518 (-)NCBICelera
Cytogenetic MapXq36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
Alpinetin  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP)
carbamazepine  (ISO)
CGP 52608  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cocaine  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
deguelin  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (EXP)
glycerol 2-phosphate  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (EXP)
leflunomide  (ISO)
myo-inositol hexakisphosphate  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
propanal  (ISO)
resveratrol  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sunitinib  (ISO)
testosterone  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Histone lysine methylation dynamics: establishment, regulation, and biological impact. Black JC, etal., Mol Cell. 2012 Nov 30;48(4):491-507. doi: 10.1016/j.molcel.2012.11.006.
2. Gestational choline supply regulates methylation of histone H3, expression of histone methyltransferases G9a (Kmt1c) and Suv39h1 (Kmt1a), and DNA methylation of their genes in rat fetal liver and brain. Davison JM, etal., J Biol Chem. 2009 Jan 23;284(4):1982-9. doi: 10.1074/jbc.M807651200. Epub 2008 Nov 10.
3. Histone H3 lysine 9 and H4 lysine 20 trimethylation and the expression of Suv4-20h2 and Suv-39h1 histone methyltransferases in hepatocarcinogenesis induced by methyl deficiency in rats. Pogribny IP, etal., Carcinogenesis. 2006 Jun;27(6):1180-6. Epub 2006 Feb 23.
4. Delta FosB mediates epigenetic desensitization of the c-fos gene after chronic amphetamine exposure. Renthal W, etal., J Neurosci. 2008 Jul 16;28(29):7344-9. doi: 10.1523/JNEUROSCI.1043-08.2008.
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
7. Suv39h1 protects from myocardial ischemia-reperfusion injury in diabetic rats. Yang B, etal., Cell Physiol Biochem. 2014;33(4):1176-85. doi: 10.1159/000358686. Epub 2014 Apr 11.
Additional References at PubMed
PMID:10949293   PMID:11788710   PMID:15788566   PMID:17707234   PMID:18004385   PMID:18485871   PMID:19218236   PMID:21402781   PMID:23451023   PMID:23509280   PMID:23695662   PMID:24413057  
PMID:27869233   PMID:31330382   PMID:31619581   PMID:34830365  


Genomics

Comparative Map Data
Suv39h1-ps1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X146,828,818 - 146,831,485 (-)NCBIGRCr8
mRatBN7.2X141,792,589 - 141,795,257 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_UtxX143,977,956 - 143,980,623 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X147,518,936 - 147,521,604 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X145,074,611 - 145,077,279 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X146,532,002 - 146,533,538 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X146,551,234 - 146,555,970 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X149,153,769 - 149,155,266 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX137,768,982 - 137,770,518 (-)NCBICelera
Cytogenetic MapXq36NCBI
SUV39H1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X48,695,554 - 48,709,016 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX48,695,554 - 48,709,016 (+)EnsemblGRCh38hg38GRCh38
GRCh37X48,553,945 - 48,567,407 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X48,440,075 - 48,452,351 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X48,311,380 - 48,323,651NCBI
CeleraX53,096,600 - 53,108,876 (-)NCBICelera
Cytogenetic MapXp11.23NCBI
HuRefX46,217,119 - 46,229,438 (+)NCBIHuRef
CHM1_1X48,586,299 - 48,598,575 (+)NCBICHM1_1
T2T-CHM13v2.0X48,106,035 - 48,119,497 (+)NCBIT2T-CHM13v2.0
Suv39h1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X7,927,401 - 7,940,994 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX7,927,410 - 7,940,999 (-)EnsemblGRCm39 Ensembl
GRCm38X8,061,171 - 8,074,760 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX8,061,171 - 8,074,760 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X7,638,297 - 7,651,886 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X7,218,263 - 7,231,545 (-)NCBIMGSCv36mm8
CeleraX3,394,838 - 3,408,427 (+)NCBICelera
Cytogenetic MapXA1.1NCBI
cM MapX3.64NCBI
Suv39h1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955543258,479 - 272,473 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955543258,479 - 271,128 (+)NCBIChiLan1.0ChiLan1.0
SUV39H1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X50,184,506 - 50,197,961 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X50,187,878 - 50,201,333 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X40,993,911 - 41,007,362 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X48,855,494 - 48,868,137 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX48,855,494 - 48,868,131 (+)Ensemblpanpan1.1panPan2
SUV39H1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X41,894,623 - 41,907,854 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX41,893,045 - 41,906,403 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX16,268,784 - 16,283,655 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X42,029,500 - 42,044,373 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX42,029,896 - 42,044,791 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X42,015,581 - 42,030,444 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X42,004,019 - 42,018,890 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X42,097,738 - 42,112,604 (+)NCBIUU_Cfam_GSD_1.0
Suv39h1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X34,406,375 - 34,420,755 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936721646,772 - 661,091 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936721646,778 - 661,144 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SUV39H1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX42,797,828 - 42,811,461 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X42,797,309 - 42,811,457 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SUV39H1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X45,820,114 - 45,834,727 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX45,822,453 - 45,834,917 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607611,300,493 - 11,313,955 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Suv39h1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624893498,973 - 512,443 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624893499,222 - 512,341 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Suv39h1-ps1
26 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:437
Count of miRNA genes:241
Interacting mature miRNAs:311
Transcripts:ENSRNOT00000008399
Prediction methods:Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X103312877148312877Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X103312877148312877Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
634346Insul4Insulin level QTL 40blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)X126975089152453651Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat

Markers in Region
Suv39h1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X141,794,206 - 141,795,097 (+)MAPPERmRatBN7.2
Rnor_6.0X146,532,194 - 146,533,084NCBIRnor6.0
Rnor_5.0X146,552,138 - 146,553,028UniSTSRnor5.0
RGSC_v3.4X149,153,949 - 149,154,839UniSTSRGSC3.4
CeleraX137,769,174 - 137,770,064UniSTS
Cytogenetic MapXq36UniSTS
Cytogenetic MapXq13UniSTS
RH129219  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X14,433,806 - 14,433,990 (+)MAPPERmRatBN7.2
Rnor_6.0X15,184,782 - 15,184,965NCBIRnor6.0
Rnor_5.0X15,967,058 - 15,967,241UniSTSRnor5.0
RGSC_v3.4X26,464,476 - 26,464,659UniSTSRGSC3.4
CeleraX14,518,467 - 14,518,650UniSTS
Cytogenetic MapXq13UniSTS
AI852103  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X14,433,583 - 14,433,688 (+)MAPPERmRatBN7.2
Rnor_6.0X15,184,559 - 15,184,663NCBIRnor6.0
Rnor_5.0X15,966,835 - 15,966,939UniSTSRnor5.0
RGSC_v3.4X26,464,253 - 26,464,357UniSTSRGSC3.4
CeleraX14,518,244 - 14,518,348UniSTS
Cytogenetic MapXq13UniSTS
Suv39h1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X14,425,284 - 14,425,458 (+)MAPPERmRatBN7.2
Rnor_6.0X15,176,260 - 15,176,433NCBIRnor6.0
Rnor_5.0X15,958,536 - 15,958,709UniSTSRnor5.0
RGSC_v3.4X26,455,954 - 26,456,127UniSTSRGSC3.4
CeleraX14,509,945 - 14,510,118UniSTS
Cytogenetic MapXq13UniSTS


Expression

RNA-SEQ Expression


Sequence


RefSeq Acc Id: XM_017588145   ⟹   XP_017443634
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
CeleraX137,768,982 - 137,770,518 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017602224   ⟹   XP_017457713
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X146,532,002 - 146,533,538 (-)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565692 AgrOrtholog
BioCyc Gene G2FUF-845 BioCyc
NCBI Gene 501653 ENTREZGENE
PhenoGen Suv39h1-ps1 PhenoGen


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-03-15 Suv39h1-ps1  SUV39H1 histone lysine methyltransferase, pseudogene 1  Suv39h1  SUV39H1 histone lysine methyltransferase  Name and Symbol changed 629549 APPROVED
2021-08-24 Suv39h1  SUV39H1 histone lysine methyltransferase  Suv39h1  suppressor of variegation 3-9 homolog 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-12-10 Suv39h1  suppressor of variegation 3-9 homolog 1  Suv39h1  suppressor of variegation 3-9 homolog 1 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-07-28 Suv39h1  suppressor of variegation 3-9 homolog 1 (Drosophila)  RGD1565692  similar to Su(var)3-9 homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1565692  similar to Su(var)3-9 homolog   RGD1565692_predicted  similar to Su(var)3-9 homolog (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1565692_predicted  similar to Su(var)3-9 homolog (predicted)  LOC501653  similar to Su(var)3-9 homolog  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC501653  similar to Su(var)3-9 homolog      Symbol and Name status set to provisional 70820 PROVISIONAL