Kmt2a (lysine methyltransferase 2A) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Kmt2a (lysine methyltransferase 2A) Rattus norvegicus
Analyze
Symbol: Kmt2a
Name: lysine methyltransferase 2A
RGD ID: 1586165
Description: Enables DNA-binding transcription factor binding activity. Involved in several processes, including cellular response to transforming growth factor beta stimulus; membrane depolarization; and response to potassium ion. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of MLL1 complex. Used to study transient cerebral ischemia. Human ortholog(s) of this gene implicated in acute myeloid leukemia; cervical cancer; myelofibrosis; and non-Hodgkin lymphoma. Orthologous to human KMT2A (lysine methyltransferase 2A); PARTICIPATES IN DNA modification pathway; histone modification pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: histone-lysine N-methyltransferase 2A; histone-lysine N-methyltransferase MLL; lysine (K)-specific methyltransferase 2A; Mixed-lineage leukemia (also acute lymphocytic leukemia 1 or trithorax Drosophila gene); Mixed-lineage leukemia (also acute lymphocytic leukemia 1 or tritorax Drosophila gene); Mll; Mll1; Mll_mapped; myeloid/lymphoid or mixed-lineage leukemia; myeloid/lymphoid or mixed-lineage leukemia (mapped); myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); myeloid/lymphoid or mixed-lineage leukemia 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8854,013,547 - 54,089,219 (-)NCBIGRCr8
mRatBN7.2845,116,763 - 45,193,320 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl845,118,814 - 45,193,181 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0849,110,407 - 49,185,872 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl849,114,990 - 49,158,971 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0847,728,915 - 47,804,551 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4847,759,175 - 47,834,586 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera844,701,780 - 44,782,476 (-)NCBICelera
Cytogenetic Map8q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-octylphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
amphetamine  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
cladribine  (ISO)
clozapine  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crotonaldehyde  (ISO)
Cuprizon  (EXP)
cytarabine  (ISO)
deoxynivalenol  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
ethanol  (ISO)
etoposide  (ISO)
fenthion  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
geldanamycin  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (EXP)
haloperidol  (ISO)
hydroquinone  (ISO)
kaempferol  (ISO)
malathion  (ISO)
methapyrilene  (ISO)
methidathion  (ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
molibresib  (ISO)
morphine  (EXP,ISO)
N-acetyl-L-cysteine  (ISO)
nickel dichloride  (EXP,ISO)
Nonylphenol  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
permethrin  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium chloride  (EXP)
prednisolone  (ISO)
propiconazole  (EXP)
pyrvinium  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
testosterone enanthate  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
torcetrapib  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Histone methylase MLL1 has critical roles in tumor growth and angiogenesis and its knockdown suppresses tumor growth in vivo. Ansari KI, etal., Oncogene. 2013 Jul 11;32(28):3359-70. doi: 10.1038/onc.2012.352. Epub 2012 Aug 27.
2. Histone lysine methylation dynamics: establishment, regulation, and biological impact. Black JC, etal., Mol Cell. 2012 Nov 30;48(4):491-507. doi: 10.1016/j.molcel.2012.11.006.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. GATA3 (GATA-Binding Protein 3)/KMT2A (Lysine-Methyltransferase-2A) Complex by Increasing H3K4-3me (Trimethylated Lysine-4 of Histone-3) Upregulates NCX3 (Na+-Ca2+ Exchanger 3) Transcription and Contributes to Ischemic Preconditioning Neuroprotection. Guida N, etal., Stroke. 2021 Nov;52(11):3680-3691. doi: 10.1161/STROKEAHA.121.034637. Epub 2021 Oct 25.
5. Menin is necessary for long term maintenance of meningioma-1 driven leukemia. Libbrecht C, etal., Leukemia. 2021 May;35(5):1405-1417. doi: 10.1038/s41375-021-01146-z. Epub 2021 Feb 4.
6. ZF-CxxC domain-containing proteins, CpG islands and the chromatin connection. Long HK, etal., Biochem Soc Trans. 2013 Jun;41(3):727-40. doi: 10.1042/BST20130028.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. Epigenetic chromatin modifications in the cortical spreading depression. Passaro D, etal., Brain Res. 2010 May 6;1329:1-9. doi: 10.1016/j.brainres.2010.03.001. Epub 2010 Mar 6.
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia. Riedel SS, etal., J Clin Invest. 2016 Apr 1;126(4):1438-50. doi: 10.1172/JCI80825. Epub 2016 Feb 29.
14. The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis. Shilatifard A Annu Rev Biochem. 2012;81:65-95. doi: 10.1146/annurev-biochem-051710-134100.
15. Inhibition of the H3K4 methyltransferase MLL1/WDR5 complex attenuates renal senescence in ischemia reperfusion mice by reduction of p16INK4a. Shimoda H, etal., Kidney Int. 2019 Nov;96(5):1162-1175. doi: 10.1016/j.kint.2019.06.021. Epub 2019 Aug 1.
16. Rearrangement of the MLL gene in acute lymphoblastic and acute myeloid leukemias with 11q23 chromosomal translocations. Thirman MJ, etal., N Engl J Med. 1993 Sep 23;329(13):909-14.
17. Deregulated expression of selected histone methylases and demethylases in prostate carcinoma. Vieira FQ, etal., Endocr Relat Cancer. 2013 Dec 16;21(1):51-61. doi: 10.1530/ERC-13-0375. Print 2014 Feb.
18. Clinical features and next-generation sequencing landscape of essential thrombocythemia, prefibrotic primary myelofibrosis, and overt fibrotic primary myelofibrosis: a Chinese monocentric retrospective study. Zhang L, etal., J Cancer Res Clin Oncol. 2022 Jun 22. doi: 10.1007/s00432-022-04067-1.
Additional References at PubMed
PMID:9639506   PMID:10656681   PMID:11313484   PMID:11555636   PMID:12453418   PMID:15199122   PMID:15556871   PMID:15640349   PMID:15741318   PMID:15960975   PMID:16618927   PMID:16990798  
PMID:19187761   PMID:19556245   PMID:20010842   PMID:20484083   PMID:20861184   PMID:21113167   PMID:22012064   PMID:22046413   PMID:22674806   PMID:24824656   PMID:25561738   PMID:25834037  
PMID:26324722   PMID:29276034   PMID:29302059  


Genomics

Comparative Map Data
Kmt2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8854,013,547 - 54,089,219 (-)NCBIGRCr8
mRatBN7.2845,116,763 - 45,193,320 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl845,118,814 - 45,193,181 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0849,110,407 - 49,185,872 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl849,114,990 - 49,158,971 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0847,728,915 - 47,804,551 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4847,759,175 - 47,834,586 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera844,701,780 - 44,782,476 (-)NCBICelera
Cytogenetic Map8q22NCBI
KMT2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811118,436,492 - 118,526,832 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11118,436,456 - 118,526,832 (+)EnsemblGRCh38hg38GRCh38
GRCh3711118,307,207 - 118,397,547 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611117,812,415 - 117,901,146 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411117,812,414 - 117,901,146NCBI
Celera11115,467,997 - 115,556,730 (+)NCBICelera
Cytogenetic Map11q23.3NCBI
HuRef11114,244,065 - 114,334,229 (+)NCBIHuRef
CHM1_111118,193,852 - 118,284,190 (+)NCBICHM1_1
T2T-CHM13v2.011118,455,794 - 118,546,121 (+)NCBIT2T-CHM13v2.0
Kmt2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39944,714,652 - 44,793,492 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl944,714,652 - 44,792,594 (-)EnsemblGRCm39 Ensembl
GRCm38944,803,355 - 44,881,352 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl944,803,355 - 44,881,296 (-)EnsemblGRCm38mm10GRCm38
MGSCv37944,611,438 - 44,689,357 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36944,554,350 - 44,632,269 (-)NCBIMGSCv36mm8
Celera942,068,287 - 42,146,334 (-)NCBICelera
Cytogenetic Map9A5.2NCBI
cM Map924.84NCBI
Kmt2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541219,586,141 - 19,665,527 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541219,586,435 - 19,670,149 (+)NCBIChiLan1.0ChiLan1.0
KMT2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29119,139,884 - 119,230,967 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111120,244,773 - 120,335,992 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011113,273,198 - 113,364,404 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111117,203,337 - 117,294,755 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11117,204,820 - 117,290,100 (+)Ensemblpanpan1.1panPan2
KMT2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1515,212,559 - 15,302,825 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl515,217,348 - 15,270,971 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha515,263,739 - 15,351,690 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0515,154,723 - 15,242,720 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl515,155,965 - 15,242,720 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1515,293,171 - 15,381,085 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0515,196,657 - 15,284,731 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0515,237,660 - 15,325,572 (-)NCBIUU_Cfam_GSD_1.0
Kmt2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947100,558,662 - 100,644,258 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365423,391,774 - 3,562,147 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365423,480,071 - 3,566,823 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KMT2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl945,743,397 - 45,824,884 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1945,743,566 - 45,828,559 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2950,878,276 - 50,914,778 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KMT2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11109,819,748 - 109,912,763 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1109,853,758 - 109,908,113 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604316,125,381 - 16,218,277 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kmt2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478413,824,541 - 13,908,077 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478413,824,507 - 13,912,672 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kmt2a
180 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:84
Count of miRNA genes:73
Interacting mature miRNAs:75
Transcripts:ENSRNOT00000020573
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83084815461290444Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)82950266570386295Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84186687675097878Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815458482492Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1359021Bp271Blood pressure QTL 2711.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82664491246711092Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)84186701070386132Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)82824291253961020Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
5684993Bmd84Bone mineral density QTL 844.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)84269268450095447Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
2302278Gluco36Glucose level QTL 364.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82950266550095447Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)82720571554998217Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat

Markers in Region
BF397432  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2845,168,205 - 45,168,345 (+)MAPPERmRatBN7.2
Rnor_6.0849,161,843 - 49,161,982NCBIRnor6.0
Rnor_5.0847,780,305 - 47,780,444UniSTSRnor5.0
RGSC_v3.4847,810,648 - 47,810,787UniSTSRGSC3.4
Celera844,753,197 - 44,753,336UniSTS
RH 3.4 Map8450.6UniSTS
Cytogenetic Map8q22UniSTS
Mll1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2845,154,547 - 45,155,354 (+)MAPPERmRatBN7.2
Rnor_6.0849,148,185 - 49,148,991NCBIRnor6.0
Rnor_5.0847,766,647 - 47,767,453UniSTSRnor5.0
RGSC_v3.4847,796,990 - 47,797,796UniSTSRGSC3.4
Celera844,739,562 - 44,740,368UniSTS
Cytogenetic Map8q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001108139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001419940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC095317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC136866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000020573   ⟹   ENSRNOP00000020573
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl845,118,814 - 45,193,181 (-)Ensembl
Rnor_6.0 Ensembl849,114,990 - 49,158,971 (-)Ensembl
RefSeq Acc Id: NM_001108139   ⟹   NP_001101609
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8854,013,547 - 54,089,219 (-)NCBI
mRatBN7.2845,116,763 - 45,192,437 (-)NCBI
RefSeq Acc Id: NM_001419940   ⟹   NP_001406869
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8854,013,547 - 54,089,219 (-)NCBI
mRatBN7.2845,116,763 - 45,192,437 (-)NCBI
RefSeq Acc Id: XM_039082345   ⟹   XP_038938273
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8854,013,555 - 54,089,191 (-)NCBI
mRatBN7.2845,116,771 - 45,193,319 (-)NCBI
RefSeq Acc Id: XM_039082346   ⟹   XP_038938274
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8854,013,555 - 54,089,191 (-)NCBI
mRatBN7.2845,116,771 - 45,193,320 (-)NCBI
RefSeq Acc Id: XM_039082347   ⟹   XP_038938275
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8854,013,555 - 54,089,191 (-)NCBI
mRatBN7.2845,116,771 - 45,193,320 (-)NCBI
RefSeq Acc Id: XM_039082348   ⟹   XP_038938276
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8854,013,555 - 54,089,191 (-)NCBI
mRatBN7.2845,116,771 - 45,193,319 (-)NCBI
RefSeq Acc Id: XM_063265434   ⟹   XP_063121504
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8854,013,555 - 54,089,191 (-)NCBI
RefSeq Acc Id: XM_063265435   ⟹   XP_063121505
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8854,013,555 - 54,089,191 (-)NCBI
RefSeq Acc Id: XM_063265436   ⟹   XP_063121506
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8854,013,555 - 54,057,874 (-)NCBI
RefSeq Acc Id: XM_063265437   ⟹   XP_063121507
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8854,013,555 - 54,089,191 (-)NCBI
Ensembl Acc Id: ENSRNOP00000020573   ⟸   ENSRNOT00000020573
RefSeq Acc Id: XP_038938275   ⟸   XM_039082347
- Peptide Label: isoform X3
- UniProtKB: A6J416 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038938274   ⟸   XM_039082346
- Peptide Label: isoform X2
- UniProtKB: A6J416 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038938276   ⟸   XM_039082348
- Peptide Label: isoform X6
- UniProtKB: A6J416 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038938273   ⟸   XM_039082345
- Peptide Label: isoform X1
- UniProtKB: F1M0L3 (UniProtKB/TrEMBL),   A6J416 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001406869   ⟸   NM_001419940
- Peptide Label: isoform 2
RefSeq Acc Id: NP_001101609   ⟸   NM_001108139
- Peptide Label: isoform 1
RefSeq Acc Id: XP_063121505   ⟸   XM_063265435
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063121504   ⟸   XM_063265434
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063121507   ⟸   XM_063265437
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063121506   ⟸   XM_063265436
- Peptide Label: isoform X7
Protein Domains
Bromo   CXXC-type   PHD-type   Post-SET   SET

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1586165 AgrOrtholog
BioCyc Gene G2FUF-30699 BioCyc
Ensembl Genes ENSRNOG00000015133 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020573.7 UniProtKB/TrEMBL
Gene3D-CATH 1.20.920.10 UniProtKB/TrEMBL
  2.170.270.10 UniProtKB/TrEMBL
  3.30.160.360 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
  6.10.250.2390 UniProtKB/TrEMBL
InterPro Bromodomain UniProtKB/TrEMBL
  Bromodomain-like_sf UniProtKB/TrEMBL
  EPHD UniProtKB/TrEMBL
  FYrich_C UniProtKB/TrEMBL
  FYrich_N UniProtKB/TrEMBL
  KMT2A_2B_SET UniProtKB/TrEMBL
  KMT2A_ePHD UniProtKB/TrEMBL
  KMT2A_PHD1 UniProtKB/TrEMBL
  KMT2A_PHD2 UniProtKB/TrEMBL
  KMT2A_PHD3 UniProtKB/TrEMBL
  MeTrfase_trithorax UniProtKB/TrEMBL
  Post-SET_dom UniProtKB/TrEMBL
  SET_dom UniProtKB/TrEMBL
  SET_dom_sf UniProtKB/TrEMBL
  Znf_CXXC UniProtKB/TrEMBL
  Znf_FYVE_PHD UniProtKB/TrEMBL
  Znf_PHD UniProtKB/TrEMBL
  Znf_PHD-finger UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
NCBI Gene 315606 ENTREZGENE
PANTHER HISTONE-LYSINE-N-METHYLTRANSFERASE 2 KMT2 FAMILY MEMBER UniProtKB/TrEMBL
  PTHR45838:SF2 UniProtKB/TrEMBL
Pfam FYRC UniProtKB/TrEMBL
  FYRN UniProtKB/TrEMBL
  PHD UniProtKB/TrEMBL
  SET UniProtKB/TrEMBL
  zf-CXXC UniProtKB/TrEMBL
  zf-HC5HC2H UniProtKB/TrEMBL
PharmGKB MLL RGD
PhenoGen Kmt2a PhenoGen
PIRSF Methyltransferase_trithorax UniProtKB/TrEMBL
PROSITE BROMODOMAIN_2 UniProtKB/TrEMBL
  EPHD UniProtKB/TrEMBL
  FYRC UniProtKB/TrEMBL
  FYRN UniProtKB/TrEMBL
  POST_SET UniProtKB/TrEMBL
  SET UniProtKB/TrEMBL
  ZF_CXXC UniProtKB/TrEMBL
  ZF_PHD_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015133 RatGTEx
SMART BROMO UniProtKB/TrEMBL
  FYRC UniProtKB/TrEMBL
  FYRN UniProtKB/TrEMBL
  PHD UniProtKB/TrEMBL
  PostSET UniProtKB/TrEMBL
  SET UniProtKB/TrEMBL
Superfamily-SCOP Bromodomain UniProtKB/TrEMBL
  FYVE_PHD_ZnF UniProtKB/TrEMBL
  SSF82199 UniProtKB/TrEMBL
UniProt A6J416 ENTREZGENE, UniProtKB/TrEMBL
  F1M0L3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Kmt2a  lysine methyltransferase 2A  Kmt2a  lysine (K)-specific methyltransferase 2A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-05-15 Kmt2a  lysine (K)-specific methyltransferase 2A  Mll  myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-02-27 Mll  myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)  Mll1  myeloid/lymphoid or mixed-lineage leukemia 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Mll1  myeloid/lymphoid or mixed-lineage leukemia 1  Mll  myeloid/lymphoid or mixed-lineage leukemia  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-04-13   myeloid/lymphoid or mixed-lineage leukemia  Mll  myeloid/lymphoid or mixed-lineage leukemia (mapped)  Name updated 737654 APPROVED
2007-04-11 Mll  myeloid/lymphoid or mixed-lineage leukemia (mapped)  Mll_mapped  myeloid/lymphoid or mixed-lineage leukemia (mapped)  Data merged from RGD:3093 737654 APPROVED
2006-11-19 Mll  myeloid/lymphoid or mixed-lineage leukemia (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Mll_mapped  myeloid/lymphoid or mixed-lineage leukemia (mapped)      Symbol and Name updated 1556543 APPROVED
2002-06-10 Mll  Mixed-lineage leukemia (also acute lymphocytic leukemia 1 or tritorax Drosophila gene)      Symbol and Name status set to approved 70586 APPROVED