Setd7 (SET domain containing 7, histone lysine methyltransferase) - Rat Genome Database

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Gene: Setd7 (SET domain containing 7, histone lysine methyltransferase) Rattus norvegicus
Analyze
Symbol: Setd7
Name: SET domain containing 7, histone lysine methyltransferase
RGD ID: 1586346
Description: Enables chromatin binding activity. Involved in positive regulation of DNA-templated transcription and response to ethanol. Predicted to be located in nucleolus. Predicted to be active in chromosome and nucleus. Used to study extrahepatic cholestasis. Biomarker of fetal alcohol spectrum disorder. Orthologous to human SETD7 (SET domain containing 7, histone lysine methyltransferase); PARTICIPATES IN carnitine biosynthetic pathway; histone modification pathway; methionine cycle/metabolic pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: histone-lysine N-methyltransferase SETD7; LOC689954; SET domain containing (lysine methyltransferase) 7; similar to Histone-lysine N-methyltransferase, H3 lysine-4 specific SET7 (Histone H3-K4 methyltransferase) (H3-K4-HMTase) (SET domain-containing protein 7)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82137,713,545 - 137,756,319 (-)NCBIGRCr8
mRatBN7.22135,562,683 - 135,605,468 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2135,562,683 - 135,605,468 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2142,138,563 - 142,181,343 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02140,250,828 - 140,293,610 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02134,882,909 - 134,925,676 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02140,576,188 - 140,618,405 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2140,576,188 - 140,618,405 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02160,051,126 - 160,093,343 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42140,413,802 - 140,456,579 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2130,058,161 - 130,100,836 (-)NCBICelera
Cytogenetic Map2q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromosome  (IBA,ISO)
nucleolus  (IEA,ISO)
nucleus  (IBA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Gestational choline supplementation normalized fetal alcohol-induced alterations in histone modifications, DNA methylation, and proopiomelanocortin (POMC) gene expression in beta-endorphin-producing POMC neurons of the hypothalamus. Bekdash RA, etal., Alcohol Clin Exp Res. 2013 Jul;37(7):1133-42. doi: 10.1111/acer.12082. Epub 2013 Feb 15.
2. Histone lysine methylation dynamics: establishment, regulation, and biological impact. Black JC, etal., Mol Cell. 2012 Nov 30;48(4):491-507. doi: 10.1016/j.molcel.2012.11.006.
3. Fetal Alcohol Exposure Reduces Dopamine Receptor D2 and Increases Pituitary Weight and Prolactin Production via Epigenetic Mechanisms. Gangisetty O, etal., PLoS One. 2015 Oct 28;10(10):e0140699. doi: 10.1371/journal.pone.0140699. eCollection 2015.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Targeting protein lysine methylation and demethylation in cancers. He Y, etal., Acta Biochim Biophys Sin (Shanghai). 2012 Jan;44(1):70-9. doi: 10.1093/abbs/gmr109.
6. Modes of p53 regulation. Kruse JP and Gu W, Cell. 2009 May 15;137(4):609-22. doi: 10.1016/j.cell.2009.04.050.
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. Epigenetic histone methylation regulates transforming growth factor beta-1 expression following bile duct ligation in rats. Sheen-Chen SM, etal., J Gastroenterol. 2014 Aug;49(8):1285-97. doi: 10.1007/s00535-013-0892-0. Epub 2013 Oct 6.
13. Epigenetic histone methylation modulates fibrotic gene expression. Sun G, etal., J Am Soc Nephrol. 2010 Dec;21(12):2069-80. doi: 10.1681/ASN.2010060633. Epub 2010 Oct 7.
Additional References at PubMed
PMID:16415881   PMID:17108971   PMID:17707234   PMID:23509280   PMID:27652271   PMID:28762861   PMID:29684621   PMID:30119254   PMID:31505256   PMID:32448511   PMID:34592314   PMID:35259059  


Genomics

Comparative Map Data
Setd7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82137,713,545 - 137,756,319 (-)NCBIGRCr8
mRatBN7.22135,562,683 - 135,605,468 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2135,562,683 - 135,605,468 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2142,138,563 - 142,181,343 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02140,250,828 - 140,293,610 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02134,882,909 - 134,925,676 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02140,576,188 - 140,618,405 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2140,576,188 - 140,618,405 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02160,051,126 - 160,093,343 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42140,413,802 - 140,456,579 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2130,058,161 - 130,100,836 (-)NCBICelera
Cytogenetic Map2q26NCBI
SETD7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384139,492,974 - 139,556,219 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4139,495,941 - 139,606,699 (-)EnsemblGRCh38hg38GRCh38
GRCh374140,414,128 - 140,477,373 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364140,646,642 - 140,697,027 (-)NCBINCBI36Build 36hg18NCBI36
Celera4137,759,367 - 137,809,746 (-)NCBICelera
Cytogenetic Map4q31.1NCBI
HuRef4136,156,561 - 136,206,720 (-)NCBIHuRef
CHM1_14140,404,455 - 140,454,786 (-)NCBICHM1_1
T2T-CHM13v2.04142,812,640 - 142,875,826 (-)NCBIT2T-CHM13v2.0
Setd7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39351,422,740 - 51,468,519 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl351,422,740 - 51,468,300 (-)EnsemblGRCm39 Ensembl
GRCm38351,515,318 - 51,560,823 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl351,515,319 - 51,560,879 (-)EnsemblGRCm38mm10GRCm38
MGSCv37351,319,240 - 51,364,745 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36351,603,247 - 51,648,752 (-)NCBIMGSCv36mm8
Celera351,246,288 - 51,292,035 (-)NCBICelera
Cytogenetic Map3CNCBI
cM Map322.5NCBI
Setd7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554284,131,103 - 4,178,250 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554284,131,431 - 4,178,250 (+)NCBIChiLan1.0ChiLan1.0
SETD7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23137,379,578 - 137,432,801 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14137,756,847 - 137,825,326 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04131,869,999 - 131,921,342 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14143,167,190 - 143,227,731 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4143,167,190 - 143,227,732 (-)Ensemblpanpan1.1panPan2
SETD7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1193,186,620 - 3,229,305 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl193,186,906 - 3,224,113 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha193,427,673 - 3,478,217 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0193,250,127 - 3,300,591 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl193,250,143 - 3,298,678 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1193,182,575 - 3,232,096 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0193,543,515 - 3,593,766 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0193,907,163 - 3,957,479 (+)NCBIUU_Cfam_GSD_1.0
Setd7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530150,657,144 - 50,705,771 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365358,094,178 - 8,137,580 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365358,094,479 - 8,143,108 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SETD7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl887,478,173 - 87,527,188 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1887,478,266 - 87,527,190 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2893,131,742 - 93,168,617 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SETD7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1786,476,101 - 86,528,146 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl786,481,726 - 86,527,779 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603765,998,142 - 66,050,297 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Setd7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477719,768,698 - 19,814,506 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477719,764,383 - 19,812,804 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Setd7
195 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:374
Count of miRNA genes:212
Interacting mature miRNAs:249
Transcripts:ENSRNOT00000017736
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2102803808147803808Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
6907363Bp357Blood pressure QTL 3574.10.002arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2129540907174540907Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1358360Sradr2Stress Responsive Adrenal Weight QTL 210.24adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)2129164097152195315Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2127447387143657569Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2122609194206936711Rat
1598862Glom9Glomerulus QTL 93.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)292337601137337601Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
1598863Cm65Cardiac mass QTL 652.3heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)292337601137337601Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1582257Gluco21Glucose level QTL 213.10.0035blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2118111229157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527143657569Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2104559726149559726Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
5135226Leukc2Leukocyte quantity QTL 2eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)2118111229149559726Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)278665616143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
738007Anxrr7Anxiety related response QTL 74.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2118189491163189491Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
1581552Pur12Proteinuria QTL 125.190.0009urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)2112103657148076632Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1354594Despr10Despair related QTL 102e-06locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2114654253159654253Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)228484589169504100Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)228484589169504100Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)259324377141596857Rat

Markers in Region
BM387085  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22135,591,509 - 135,591,696 (+)MAPPERmRatBN7.2
Rnor_6.02140,604,447 - 140,604,633NCBIRnor6.0
Rnor_5.02160,079,385 - 160,079,571UniSTSRnor5.0
RGSC_v3.42140,442,619 - 140,442,805UniSTSRGSC3.4
Celera2130,086,884 - 130,087,070UniSTS
RH 3.4 Map2848.1UniSTS
Cytogenetic Map2q26UniSTS
AU046527  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22135,581,256 - 135,581,468 (+)MAPPERmRatBN7.2
Rnor_6.02140,594,204 - 140,594,415NCBIRnor6.0
Rnor_5.02160,069,142 - 160,069,353UniSTSRnor5.0
RGSC_v3.42140,432,377 - 140,432,588UniSTSRGSC3.4
Celera2130,076,736 - 130,076,947UniSTS
Cytogenetic Map2q26UniSTS
AI011764  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22135,595,954 - 135,596,191 (+)MAPPERmRatBN7.2
Rnor_6.02140,608,892 - 140,609,128NCBIRnor6.0
Rnor_5.02160,083,830 - 160,084,066UniSTSRnor5.0
RGSC_v3.42140,447,064 - 140,447,300UniSTSRGSC3.4
Celera2130,091,329 - 130,091,565UniSTS
RH 3.4 Map2859.1UniSTS
Cytogenetic Map2q26UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000017736   ⟹   ENSRNOP00000017736
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2135,562,683 - 135,605,468 (-)Ensembl
Rnor_6.0 Ensembl2140,576,188 - 140,618,405 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103869   ⟹   ENSRNOP00000090313
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2135,562,683 - 135,586,215 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111366   ⟹   ENSRNOP00000084831
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2135,562,683 - 135,595,209 (-)Ensembl
RefSeq Acc Id: NM_001109558   ⟹   NP_001103028
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82137,713,545 - 137,756,319 (-)NCBI
mRatBN7.22135,562,683 - 135,605,468 (-)NCBI
Rnor_6.02140,576,188 - 140,618,405 (-)NCBI
Rnor_5.02160,051,126 - 160,093,343 (-)NCBI
RGSC_v3.42140,413,802 - 140,456,579 (-)RGD
Celera2130,058,161 - 130,100,836 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001103028 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM14980 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000017736.5
  ENSRNOP00000084831.1
  ENSRNOP00000090313.1
RefSeq Acc Id: NP_001103028   ⟸   NM_001109558
- UniProtKB: D4ADE5 (UniProtKB/TrEMBL),   A6JV72 (UniProtKB/TrEMBL),   A0A8I6A0F7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017736   ⟸   ENSRNOT00000017736
Ensembl Acc Id: ENSRNOP00000090313   ⟸   ENSRNOT00000103869
Ensembl Acc Id: ENSRNOP00000084831   ⟸   ENSRNOT00000111366
Protein Domains
SET

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4ADE5-F1-model_v2 AlphaFold D4ADE5 1-366 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691320
Promoter ID:EPDNEW_R1845
Type:initiation region
Name:Setd7_1
Description:SET domain containing 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02140,618,379 - 140,618,439EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1586346 AgrOrtholog
BioCyc Gene G2FUF-53128 BioCyc
Ensembl Genes ENSRNOG00000013045 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017736.7 UniProtKB/TrEMBL
  ENSRNOT00000103869.1 UniProtKB/TrEMBL
  ENSRNOT00000111366.1 UniProtKB/TrEMBL
Gene3D-CATH 2.170.270.10 UniProtKB/TrEMBL
  Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain UniProtKB/TrEMBL
InterPro Hist-Lys_N-MeTrfase_SET UniProtKB/TrEMBL
  MORN UniProtKB/TrEMBL
  SET_dom UniProtKB/TrEMBL
  SET_dom_sf UniProtKB/TrEMBL
  SETD7_SET UniProtKB/TrEMBL
KEGG Report rno:689954 UniProtKB/TrEMBL
NCBI Gene 689954 ENTREZGENE
PANTHER HISTONE-LYSINE N-METHYLTRANSFERASE SETD7 UniProtKB/TrEMBL
  HISTONE-LYSINE N-METHYLTRANSFERASE SETD7 UniProtKB/TrEMBL
Pfam MORN UniProtKB/TrEMBL
  SET UniProtKB/TrEMBL
  SET7_N UniProtKB/TrEMBL
PhenoGen Setd7 PhenoGen
PIRSF Histone_Lys_mtfrase_SET UniProtKB/TrEMBL
PROSITE SAM_MT43_13 UniProtKB/TrEMBL
  SET UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013045 RatGTEx
Superfamily-SCOP Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain UniProtKB/TrEMBL
  SSF82199 UniProtKB/TrEMBL
UniProt A0A8I6A0F7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GI35_RAT UniProtKB/TrEMBL
  A6JV72 ENTREZGENE, UniProtKB/TrEMBL
  D4ADE5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-04 Setd7  SET domain containing 7, histone lysine methyltransferase  Setd7  SET domain containing (lysine methyltransferase) 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Setd7  SET domain containing (lysine methyltransferase) 7  LOC689954  similar to Histone-lysine N-methyltransferase, H3 lysine-4 specific SET7 (Histone H3-K4 methyltransferase) (H3-K4-HMTase) (SET domain-containing protein 7)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC689954  similar to Histone-lysine N-methyltransferase, H3 lysine-4 specific SET7 (Histone H3-K4 methyltransferase) (H3-K4-HMTase) (SET domain-containing protein 7)  LOC679429  similar to Histone-lysine N-methyltransferase, H3 lysine-4 specific SET7 (Histone H3-K4 methyltransferase) (H3-K4-HMTase) (SET domain-containing protein 7)  Data merged from RGD:1588334 1643240 APPROVED
2006-11-19 LOC689954  similar to Histone-lysine N-methyltransferase, H3 lysine-4 specific SET7 (Histone H3-K4 methyltransferase) (H3-K4-HMTase) (SET domain-containing protein 7)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC679429  similar to Histone-lysine N-methyltransferase, H3 lysine-4 specific SET7 (Histone H3-K4 methyltransferase) (H3-K4-HMTase) (SET domain-containing protein 7)      Symbol and Name status set to provisional 70820 PROVISIONAL