Kmt5a (lysine methyltransferase 5A)

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Gene: Kmt5a (lysine methyltransferase 5A) Rattus norvegicus

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Symbol:

Kmt5a

Name:

lysine methyltransferase 5A

RGD ID:

1587560

Description:

Predicted to enable histone H4K20 methyltransferase activity and transcription corepressor activity. Predicted to be involved in negative regulation of nucleobase-containing compound metabolic process; peptidyl-lysine monomethylation; and regulation of DNA damage response, signal transduction by p53 class mediator. Predicted to be located in chromatin; cytosol; and nucleoplasm. Predicted to be active in nucleus and polytene chromosome. Orthologous to human KMT5A (lysine methyltransferase 5A); PARTICIPATES IN histone modification pathway; methionine cycle/metabolic pathway; p53 signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; acetamide.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

histone methyltransferase Pr-set7/Set8; histone-lysine N-methyltransferase SETD8; LOC689820; lysine (K)-specific methyltransferase 5A; N-lysine methyltransferase KMT5A; N-lysine methyltransferase SETD8; Pr-set7; RGD1305893; SET domain containing (lysine methyltransferase) 8; SET domain-containing 8; Setd8; similar to SET domain-containing protein

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	KMT5A (lysine methyltransferase 5A)	RGD	RGD
Mus musculus (house mouse):	Kmt5a (lysine methyltransferase 5A)	RGD	RGD
Chinchilla lanigera (long-tailed chinchilla):	Kmt5a (lysine methyltransferase 5A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	KMT5A (lysine methyltransferase 5A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Kmt5a (lysine methyltransferase 5A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	KMT5A (lysine methyltransferase 5A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	KMT5A (lysine methyltransferase 5A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Kmt5a (lysine methyltransferase 5A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Kmt5a (lysine methyltransferase 5A)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	KMT5A (lysine methyltransferase 5A)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	set-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	PR-Set7	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	kmt5aa	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	kmt5a	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	37,800,339 - 37,823,706 (-)	NCBI		GRCr8
mRatBN7.2	12	32,139,353 - 32,167,777 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	32,139,178 - 32,162,711 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	33,319,745 - 33,335,298 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	33,931,073 - 33,946,626 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	32,982,943 - 32,998,497 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	37,558,150 - 37,581,183 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	37,559,770 - 37,574,750 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	39,428,363 - 39,452,079 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	33,254,018 - 33,270,657 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	12	33,829,691 - 33,843,975 (-)	NCBI		Celera
Cytogenetic Map	12	q15	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

prostate cancer (ISO)

short chain acyl-CoA dehydrogenase deficiency (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

4,4'-sulfonyldiphenol (ISO)

acetamide (EXP)

acrylamide (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

benzo[a]pyrene (ISO)

berberine (ISO)

bis(2-chloroethyl) sulfide (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

choline (ISO)

cobalt dichloride (ISO)

copper(II) sulfate (ISO)

curcumin (ISO)

cyclosporin A (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (ISO)

diethylstilbestrol (ISO)

diuron (EXP)

doxorubicin (ISO)

endosulfan (ISO)

epoxiconazole (ISO)

ethanol (ISO)

folic acid (ISO)

fulvestrant (ISO)

inulin (ISO)

isoprenaline (ISO)

ketamine (EXP)

L-methionine (ISO)

lead(0) (ISO)

methylmercury chloride (ISO)

paracetamol (EXP,ISO)

pentachlorophenol (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

pirinixic acid (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

tetrachloromethane (EXP)

tetraphene (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trimellitic anhydride (ISO)

triphenyl phosphate (EXP,ISO)

triptonide (ISO)

valproic acid (ISO)

zearalenone (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

chromatin remodeling (IEA)

methylation (IEA)

negative regulation of DNA-templated transcription (ISO)

negative regulation of double-strand break repair via homologous recombination (ISO)

negative regulation of transcription by RNA polymerase II (ISO)

peptidyl-lysine monomethylation (ISO)

regulation of DNA damage response, signal transduction by p53 class mediator (IBA,ISO)

regulation of transcription by RNA polymerase II (IBA)

Cellular Component

chromatin (ISO)

cytosol (ISO)

nucleoplasm (ISO)

nucleus (IBA)

polytene chromosome (IBA)

Molecular Function

histone H4K20 methyltransferase activity (IBA,ISO)

histone H4K20 monomethyltransferase activity (IEA)

histone methyltransferase activity (ISO)

protein binding (ISO)

protein-lysine N-methyltransferase activity (ISO)

transcription corepressor activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

histone modification pathway (ISO)

lysine degradation pathway (IEA)

methionine cycle/metabolic pathway (ISO)

p53 signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Targeting protein lysine methylation and demethylation in cancers.	He Y, etal., Acta Biochim Biophys Sin (Shanghai). 2012 Jan;44(1):70-9. doi: 10.1093/abbs/gmr109.
3.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
4.	GOA pipeline	RGD automated data pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:15326124	PMID:15632090	PMID:17707234	PMID:18408754	PMID:18474616	PMID:22720056	PMID:33398850	PMID:36936537	PMID:38301049	PMID:38565081

Genomics

Comparative Map Data

Kmt5a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	37,800,339 - 37,823,706 (-)	NCBI		GRCr8
mRatBN7.2	12	32,139,353 - 32,167,777 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	32,139,178 - 32,162,711 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	33,319,745 - 33,335,298 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	33,931,073 - 33,946,626 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	32,982,943 - 32,998,497 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	37,558,150 - 37,581,183 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	37,559,770 - 37,574,750 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	39,428,363 - 39,452,079 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	33,254,018 - 33,270,657 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	12	33,829,691 - 33,843,975 (-)	NCBI		Celera
Cytogenetic Map	12	q15	NCBI

KMT5A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	123,384,132 - 123,409,353 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	123,384,132 - 123,409,353 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	123,868,679 - 123,893,900 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	122,434,657 - 122,459,853 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	12	123,461,215 - 123,486,597 (+)	NCBI		Celera
Cytogenetic Map	12	q24.31	NCBI
HuRef	12	120,829,632 - 120,854,730 (+)	NCBI		HuRef
CHM1_1	12	123,683,455 - 123,708,653 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	123,380,646 - 123,405,922 (+)	NCBI		T2T-CHM13v2.0

Kmt5a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	124,577,980 - 124,600,371 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	124,577,993 - 124,600,371 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	124,439,930 - 124,462,311 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	124,439,930 - 124,462,308 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	124,889,939 - 124,912,316 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	124,700,548 - 124,722,925 (+)	NCBI		MGSCv36	mm8
Celera	5	121,513,480 - 121,535,737 (+)	NCBI		Celera
Cytogenetic Map	5	F	NCBI
cM Map	5	63.59	NCBI

Kmt5a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955482	5,485,649 - 5,501,636 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955482	5,488,151 - 5,500,764 (-)	NCBI	ChiLan1.0	ChiLan1.0

KMT5A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	131,471,304 - 131,496,861 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	131,467,681 - 131,533,955 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	120,982,059 - 121,007,360 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	125,211,201 - 125,234,986 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

Kmt5a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	158,125,115 - 158,134,261 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936558	1,346,040 - 1,366,601 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

KMT5A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	29,523,105 - 29,543,493 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	29,523,102 - 29,543,522 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	31,215,887 - 31,234,841 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

KMT5A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	118,712,964 - 118,743,322 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	118,723,029 - 118,743,325 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	126,539,281 - 126,565,296 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Kmt5a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624747	23,289,119 - 23,308,682 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624747	23,289,118 - 23,309,465 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Kmt5a
179 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	32
Count of miRNA genes:	30
Interacting mature miRNAs:	31
Transcripts:	ENSRNOT00000066253
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631560	Apr1	Acute phase response QTL 1	6.1		orosomucoid 1 amount (VT:0010541)	plasma orosomucoid 1 level (CMO:0001467)	12	19144362	46669029	Rat
8552964	Pigfal17	Plasma insulin-like growth factor 1 level QTL 17	3.5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	5564495	46669029	Rat
8693635	Alc28	Alcohol consumption QTL 28	2.7	0.439	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	12	23081340	44726024	Rat
61324	Eae5	Experimental allergic encephalomyelitis QTL 5	14		nervous system integrity trait (VT:0010566)	percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)	12	19610870	46669029	Rat
9590147	Scort7	Serum corticosterone level QTL 7	13.61	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	12	1	42110980	Rat
1549829	Scl48	Serum cholesterol level QTL 48	5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	12	9603277	46669029	Rat
737822	Alc10	Alcohol consumption QTL 10	2.2		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	12	19610870	40218516	Rat
2293684	Bmd26	Bone mineral density QTL 26	4.4	0.0002	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	12	15872653	32974238	Rat
70169	Eae13	Experimental allergic encephalomyelitis QTL 13		0.032	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	12	24139202	36638073	Rat
1600386	Calcic2	Intracellular calcium level QTL 2		0.001	platelet physiology trait (VT:0005464)	platelet intracellular calcium level (CMO:0000922)	12	28064433	46669029	Rat
1302792	Scl21	Serum cholesterol level QTL 21	3.8	0.0011	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	12	7196730	46669029	Rat
1556747	Calcic1	Intracellular calcium level QTL 1		3.6	platelet calcium amount (VT:0010500)	platelet intracellular calcium level (CMO:0000922)	12	28064433	40130419	Rat
631829	Alc6	Alcohol consumption QTL 6	4.7		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	12	28607526	37691617	Rat
8693658	Alc33	Alcohol consumption QTL 33	2.1	0.68	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	12	23081340	43551788	Rat
1598855	Bp294	Blood pressure QTL 294	3.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	1	34851688	Rat
1331761	Bp218	Blood pressure QTL 218	2.973		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	11073825	45055165	Rat
8694179	Bw150	Body weight QTL 150	2.9	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	12	1	42110980	Rat
7411545	Bw128	Body weight QTL 128	5.2	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	12	1	42110980	Rat
7411547	Bw129	Body weight QTL 129		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	5564495	46669029	Rat
737979	Pia22	Pristane induced arthritis QTL 22	53.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	1	44465750	Rat
1298081	Cia25	Collagen induced arthritis QTL 25	4.7		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	19610889	35682913	Rat
2300186	Bmd59	Bone mineral density QTL 59	7.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	12	10474137	46669029	Rat
7411660	Foco28	Food consumption QTL 28	10.9	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
70213	Niddm27	Non-insulin dependent diabetes mellitus QTL 27	3.72		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	19835789	38193007	Rat
7411641	Foco19	Food consumption QTL 19	27.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	5564495	46669029	Rat
7411643	Foco20	Food consumption QTL 20		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	20328819	46669029	Rat
5684888	Pia42	Pristane induced arthritis QTL 42			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	19610870	42828880	Rat
1549912	Bp268	Blood pressure QTL 268			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	10	13182736	46669029	Rat
2302060	Pia37	Pristane induced arthritis QTL 37	6.1	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	12	13198157	46669029	Rat
1641928	Alcrsp5	Alcohol response QTL 5			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	12	12812385	46669029	Rat
1300162	Bp188	Blood pressure QTL 188	3.19		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	32103174	45899022	Rat
8552912	Pigfal6	Plasma insulin-like growth factor 1 level QTL 6	5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	5564498	46669029	Rat
10059594	Kidm46	Kidney mass QTL 46	3.79	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	12	6107579	46669029	Rat
9590086	Insglur6	Insulin/glucose ratio QTL 6	18.97	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	12	1	42110980	Rat
8552918	Pigfal7	Plasma insulin-like growth factor 1 level QTL 7			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	5564495	46669029	Rat
1549902	Bp269	Blood pressure QTL 269			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	13182736	46669029	Rat
61404	Bw120	Body weight QTL 120	5.1		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	12	12351619	46669029	Rat
1300175	Cm5	Cardiac mass QTL 5	3.78		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	12	28064433	45899022	Rat
1331787	Rf41	Renal function QTL 41	2.998		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	12	28064557	40218380	Rat
2293699	Bss49	Bone structure and strength QTL 49	5.61	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	12	10474137	46669029	Rat
634351	Apr5	Acute phase response QTL 5	6.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	12	1	44503507	Rat
634350	Apr4	Acute phase response QTL 4	6		orosomucoid 1 amount (VT:0010541)	plasma orosomucoid 1 level (CMO:0001467)	12	1172005	46172005	Rat
7387292	Kidm42	Kidney mass QTL 42	3.03	0.0004	kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	12	1	36247923	Rat
61421	Cia12	Collagen induced arthritis QTL 12	4.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	13635523	35682913	Rat
2303569	Gluco44	Glucose level QTL 44	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	12812385	46669029	Rat
7411586	Foco5	Food consumption QTL 5	5.4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
2303575	Insul14	Insulin level QTL 14	4		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	12	1	42450532	Rat
7411588	Foco6	Food consumption QTL 6		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	5564495	46669029	Rat
2302042	Pia38	Pristane induced arthritis QTL 38	3.5	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	12	1	44503507	Rat
7411595	Foco9	Food consumption QTL 9	4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
7411597	Foco10	Food consumption QTL 10		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	5564495	46669029	Rat
631543	Bp83	Blood pressure QTL 83	5.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	15550826	38478808	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001246665	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001413637	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006249328	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006249330	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017598457	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017598458	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089771	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089773	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063271675	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063271676	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063271677	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063271679	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010056419	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB606422	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473973	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DV214760	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DY311222	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JN896763	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000066253 ⟹ ENSRNOP00000062763

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	32,139,470 - 32,162,711 (-)	Ensembl
Rnor_6.0 Ensembl	12	37,559,770 - 37,574,750 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000106064 ⟹ ENSRNOP00000095821

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	32,139,178 - 32,156,245 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000106166 ⟹ ENSRNOP00000084143

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	32,139,470 - 32,161,830 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000108981 ⟹ ENSRNOP00000092997

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	32,139,178 - 32,161,830 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000111843 ⟹ ENSRNOP00000088749

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	32,139,178 - 32,161,830 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000114055 ⟹ ENSRNOP00000080894

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	32,139,178 - 32,162,646 (-)	Ensembl

RefSeq Acc Id:

NM_001246665 ⟹ NP_001233594

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	37,800,344 - 37,818,026 (-)	NCBI
mRatBN7.2	12	32,139,358 - 32,157,043 (-)	NCBI
Rnor_6.0	12	37,559,770 - 37,574,750 (-)	NCBI
Rnor_5.0	12	39,428,363 - 39,452,079 (-)	NCBI
Celera	12	33,829,691 - 33,843,975 (-)	NCBI

Sequence:

show sequence

ATGGTGGAGCGGAGGGGCCCGGGGAGGCCCCGCAGCGACGGGGAGAACGTGTTTGCTGGGCAGT
CAAAGATCTATGCCTACATGAGTCCGAACAAATGCTCTGGAATGCGTTCTCCACTGCAGGAAGA
GAACTCCGTCGCACATCATGAGGTCAAATGCCCGGGGAAACCATTGGCCGGAATCTACAGGAAG
CGAGAAGAGAAAAGAAACGCTGGGAATGTTATCCGAAGCGCTGTGAAGTCAGAAGAACAGAAGA
GCAAAGATACCAGGAGAGGTCCCCTGGCGCCTTTTCCAAACCAAAAACCTGAAGCAACAGAACC
TCCAAAAACTCCACCCCCGTCATGTGATTCTACCAGTGTAGCGGTTGCTAAGCAAGCCCTGAAA
AAGCCCCTCAAGGGCAAGCAGGCCCCTCGGAAGAAGTCTCAAGGGAAGACACAGCAGAATAGAA
AACTCACAGATTTCTACCCCGTGCGAAGGAGCTCCAGGAAGAGCAAAGCTGAGCTGCAGTCTGA
AGAAAGGAAGAAGATAGATGAGCTAATTGAGAGCGGGAAGGAAGAGGGCATGAAGATTGATCTA
ATCGATGGCAAAGGCAGGGGTGTGATTGCTACCAAGCGATTCTCCCGGGGAGACTTTGTGGTAG
AATACCATGGAGACCTCATTGAAATCACCGATGCCAAGAAGCGGGAGGCTCTGTATGCACAGGA
CCCCTCCACGGGCTGCTACATGTACTATTTTCAATATCTGAGCAAAACCTACTGCGTGGATGCC
ACTCAAGAAACGAACCGCCTGGGGAGACTGATCAATCACAGTAAGTGTGGGAATTGCCAGACCA
AACTGCATGACATCGACGGCGTGCCTCACCTCATCCTCATAGCCTCCCGAGACATTGCGGCCGG
GGAGGAGCTCCTGTACGACTATGGAGACCGGAGCAAGGCCTCCATCGAAGCCTACCCTTGGCTG
AAGCACTAA

hide sequence

RefSeq Acc Id:

NM_001413637 ⟹ NP_001400566

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	37,800,344 - 37,818,026 (-)	NCBI
mRatBN7.2	12	32,139,358 - 32,157,043 (-)	NCBI

RefSeq Acc Id:

XM_006249328 ⟹ XP_006249390

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	37,800,339 - 37,823,706 (-)	NCBI
mRatBN7.2	12	32,139,353 - 32,162,728 (-)	NCBI
Rnor_6.0	12	37,558,150 - 37,581,183 (-)	NCBI
Rnor_5.0	12	39,428,363 - 39,452,079 (-)	NCBI

Sequence:

show sequence

GCAGTTGGCTACAGTTGTTGCAACTTTTTTCGAAAGCTGGGTTTCCCGGGAGATTCCAGACGGT
GACAGAGCGGGGCCATGGCTAGAGGCAGGAAGATGTGCAAGCCCCGCGCGGTGGAGGCGGCGGC
AGCGGCGGTGGCGGCGACGGCCCCGGGCCCGGAGATGGTGGAGCGGAGGGGCCCGGGGAGGCCC
CGCAGCGACGGGGAGAACGTGTTTGCTGGGCAGTCAAAGATCTATGCCTACATGAGTCCGAACA
AATGCTCTGGAATGCGTTCTCCACTGCAGGAAGAGAACTCCGTCGCACATCATGAGGTCAAATG
CCCGGGGAAACCATTGGCCGGAATCTACAGGAAGCGAGAAGAGAAAAGAAACGCTGGGAATGTT
ATCCGAAGCGCTGTGAAGTCAGAAGAACAGAAGAGCAAAGATACCAGGAGAGGTCCCCTGGCGC
CTTTTCCAAACCAAAAACCTGAAGCAACAGAACCTCCAAAAACTCCACCCCCGTCATGTGATTC
TACCAGTGTAGCGGTTGCTAAGCAAGCCCTGAAAAAGCCCCTCAAGGGCAAGCAGGCCCCTCGG
AAGAAGTCTCAAGGGAAGACACAGCAGAATAGAAAACTCACAGATTTCTACCCCGTGCGAAGGA
GCTCCAGGAAGAGCAAAGCTGAGCTGCAGTCTGAAGAAAGGAAGAAGATAGATGAGCTAATTGA
GAGCGGGAAGGAAGAGGGCATGAAGATTGATCTAATCGATGGCAAAGGCAGGGGTGTGATTGCT
ACCAAGCGATTCTCCCGGGGAGACTTTGTGGTAGAATACCATGGAGACCTCATTGAAATCACCG
ATGCCAAGAAGCGGGAGGCTCTGTATGCACAGGACCCCTCCACGGGCTGCTACATGTACTATTT
TCAATATCTGAGCAAAACCTACTGCGTGGATGCCACTCAAGAAACGAACCGCCTGGGGAGACTG
ATCAATCACAGTAAGTGTGGGAATTGCCAGACCAAACTGCATGACATCGACGGCGTGCCTCACC
TCATCCTCATAGCCTCCCGAGACATTGCGGCCGGGGAGGAGCTCCTGTACGACTATGGAGACCG
GAGCAAGGCCTCCATCGAAGCCTACCCTTGGCTGAAGCACTAACCAACCATGTGGCCTCCCTGC
CTCCCTGCCACCCTGCCTCCTTCAAAGGACAAAGTGCCCTCAAAGGGAAATGAATTTTTTACAC
ACACACACACACACACACACACACACACACACACACACACACACACACTCACACTCACTCTTAG
CTAATTACTTCAAATGTTTTTAAAAAGTATATTAAAGATGCCTTTTCATGTAGTATTTAAATAT
CTGTTACAGGTTTCCAAGGTGGACTTGAACAGATGGCCTTATATTACCAAAACTTTTATATTCT
AGTTGTTTTTCTACCTTTTTGCATACAAGCTGAACATTTGTGCTTCCCGCGCAGTGTAAGACTC
GGCACAGGTTTTAGAGAATGGAGTTGAACATGAACTAGGAAGCCGGGCTCTGCCCAAGATGAAA
GCCAGGACTCCCCCGCACCCCACGTCCGAGGACAGGCCGGTGTGAGGGTGCTGCCACCCCCACG
CACAGCCTGGACGGGATGTCTCCAAGCTCTTGTTCTCCTCAACGTCTTGACAGGTGTACACATT
GACGTGTATGAATATTTTTTAGCAAAAGTTTCACAGTAAGCTAGTCTTCCCCTCTGCTTTCTCC
AAAGCTTACTGAGCCCGGGGCTCGGAGGCCCGGCCAGGAACAGACCTCTTCCACAGGCTTACGG
CTTTTCCAGGCACCTTGAAGCATCAGGGTGGGCAGTCAGACTAGAGGCGGGCCGGGAAAAGCAC
TGTTCTCCTGCCCAAGAAGGGCAGGTCTCCTGAAACTGCATTAATTCTTTATAGAAATGTGAAC
ACTGAATTTATTTTAAAAAATAATAATAAAAAAACAAAATAGTAAAAAAAAATTTAAAAAGAAA
AAAAATGGAAAAAAAAAACCCACAGAAAACAACTTAACATGTATATAGGTTTTGAAGGGAGTGA
AATGAATGCAGTTTTCTTTTCTTCTGGGGTTTATTTTTCTTTTTGGCTTGGCTGGTTGGTTTGT
GTAGAGAAGATTTGAGATGGTACTCTATTCTAATCAAAAGTGAGGTTTGTAGTGGGACCAGAAA
TTACTAAGCCCACACCCCCTCCCCAACCCCAATTCTGCTACGTGGGAAGTTCTCTACCTGCTGT
CAAGGCAGAACCCCTGGTCTCCCGTGAAGATGCCGTCAGTCCTGTGGGCATCAGACACCAGATG
TGTTTGGCTCTAGGGTACCTGGCAGCCCGCAAGGCTTAGCAGCCAGAGATCAGGAGGATCCTTC
AGTTGTAACCTGTGATAGCAAGAGTAGGCTTCCTTCTCCCTCCTTGGGGAGGACTAACCATTCA
CCTTCAGTCCAGGGGGCCTGGGGTTCAGGAGCCAGGTGTAAGAGCCTACCCTTGTCCCCAGTAC
CTCCATCTCCCAGCCTCATGATGGTGCTACCTAAGAAAGTCTTCCCCGCACCCTTTGCTAGCCC
AGTCAGTGGTCAGACTTGGAGGAGGATCCGACAGGAGGGTGTAACTGTGAGATAAAATGTCTTG
GTTGTACCTGTTTGTGGCTTAGCTTTGTATTTAAATAGCAAACAAAAAAAGGAAATAAACTTGA
AACTTATTTGTCATCTTAAAAATAAAGCAAAAAAATTAAAGTATTTATTTCCAGGCAAGGGCA

hide sequence

RefSeq Acc Id:

XM_006249330 ⟹ XP_006249392

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	37,800,339 - 37,816,831 (-)	NCBI
mRatBN7.2	12	32,139,353 - 32,155,853 (-)	NCBI
Rnor_6.0	12	37,558,150 - 37,574,027 (-)	NCBI
Rnor_5.0	12	39,428,363 - 39,452,079 (-)	NCBI

Sequence:

show sequence

TTAGCCTGTTTCTGTGCTAGTGGCTGACTCCCTAGCCTGGGGGGCTAACCCCTGACTCAGCCCA
GCCCTTCGAATCCAGAGTCAGTTTTCCCTGGGTCATTCTGACCTCCCTGCTGCTGGAGAACGTG
TTTGCTGGGCAGTCAAAGATCTATGCCTACATGAGTCCGAACAAATGCTCTGGAATGCGTTCTC
CACTGCAGGAAGAGAACTCCGTCGCACATCATGAGGTCAAATGCCCGGGGAAACCATTGGCCGG
AATCTACAGGAAGCGAGAAGAGAAAAGAAACGCTGGGAATGTTATCCGAAGCGCTGTGAAGTCA
GAAGAACAGAAGAGCAAAGATACCAGGAGAGGTCCCCTGGCGCCTTTTCCAAACCAAAAACCTG
AAGCAACAGAACCTCCAAAAACTCCACCCCCGTCATGTGATTCTACCAGTGTAGCGGTTGCTAA
GCAAGCCCTGAAAAAGCCCCTCAAGGGCAAGCAGGCCCCTCGGAAGAAGTCTCAAGGGAAGACA
CAGCAGAATAGAAAACTCACAGATTTCTACCCCGTGCGAAGGAGCTCCAGGAAGAGCAAAGCTG
AGCTGCAGTCTGAAGAAAGGAAGAAGATAGATGAGCTAATTGAGAGCGGGAAGGAAGAGGGCAT
GAAGATTGATCTAATCGATGGCAAAGGCAGGGGTGTGATTGCTACCAAGCGATTCTCCCGGGGA
GACTTTGTGGTAGAATACCATGGAGACCTCATTGAAATCACCGATGCCAAGAAGCGGGAGGCTC
TGTATGCACAGGACCCCTCCACGGGCTGCTACATGTACTATTTTCAATATCTGAGCAAAACCTA
CTGCGTGGATGCCACTCAAGAAACGAACCGCCTGGGGAGACTGATCAATCACAGTAAGTGTGGG
AATTGCCAGACCAAACTGCATGACATCGACGGCGTGCCTCACCTCATCCTCATAGCCTCCCGAG
ACATTGCGGCCGGGGAGGAGCTCCTGTACGACTATGGAGACCGGAGCAAGGCCTCCATCGAAGC
CTACCCTTGGCTGAAGCACTAACCAACCATGTGGCCTCCCTGCCTCCCTGCCACCCTGCCTCCT
TCAAAGGACAAAGTGCCCTCAAAGGGAAATGAATTTTTTACACACACACACACACACACACACA
CACACACACACACACACACACACACACTCACACTCACTCTTAGCTAATTACTTCAAATGTTTTT
AAAAAGTATATTAAAGATGCCTTTTCATGTAGTATTTAAATATCTGTTACAGGTTTCCAAGGTG
GACTTGAACAGATGGCCTTATATTACCAAAACTTTTATATTCTAGTTGTTTTTCTACCTTTTTG
CATACAAGCTGAACATTTGTGCTTCCCGCGCAGTGTAAGACTCGGCACAGGTTTTAGAGAATGG
AGTTGAACATGAACTAGGAAGCCGGGCTCTGCCCAAGATGAAAGCCAGGACTCCCCCGCACCCC
ACGTCCGAGGACAGGCCGGTGTGAGGGTGCTGCCACCCCCACGCACAGCCTGGACGGGATGTCT
CCAAGCTCTTGTTCTCCTCAACGTCTTGACAGGTGTACACATTGACGTGTATGAATATTTTTTA
GCAAAAGTTTCACAGTAAGCTAGTCTTCCCCTCTGCTTTCTCCAAAGCTTACTGAGCCCGGGGC
TCGGAGGCCCGGCCAGGAACAGACCTCTTCCACAGGCTTACGGCTTTTCCAGGCACCTTGAAGC
ATCAGGGTGGGCAGTCAGACTAGAGGCGGGCCGGGAAAAGCACTGTTCTCCTGCCCAAGAAGGG
CAGGTCTCCTGAAACTGCATTAATTCTTTATAGAAATGTGAACACTGAATTTATTTTAAAAAAT
AATAATAAAAAAACAAAATAGTAAAAAAAAATTTAAAAAGAAAAAAAATGGAAAAAAAAAACCC
ACAGAAAACAACTTAACATGTATATAGGTTTTGAAGGGAGTGAAATGAATGCAGTTTTCTTTTC
TTCTGGGGTTTATTTTTCTTTTTGGCTTGGCTGGTTGGTTTGTGTAGAGAAGATTTGAGATGGT
ACTCTATTCTAATCAAAAGTGAGGTTTGTAGTGGGACCAGAAATTACTAAGCCCACACCCCCTC
CCCAACCCCAATTCTGCTACGTGGGAAGTTCTCTACCTGCTGTCAAGGCAGAACCCCTGGTCTC
CCGTGAAGATGCCGTCAGTCCTGTGGGCATCAGACACCAGATGTGTTTGGCTCTAGGGTACCTG
GCAGCCCGCAAGGCTTAGCAGCCAGAGATCAGGAGGATCCTTCAGTTGTAACCTGTGATAGCAA
GAGTAGGCTTCCTTCTCCCTCCTTGGGGAGGACTAACCATTCACCTTCAGTCCAGGGGGCCTGG
GGTTCAGGAGCCAGGTGTAAGAGCCTACCCTTGTCCCCAGTACCTCCATCTCCCAGCCTCATGA
TGGTGCTACCTAAGAAAGTCTTCCCCGCACCCTTTGCTAGCCCAGTCAGTGGTCAGACTTGGAG
GAGGATCCGACAGGAGGGTGTAACTGTGAGATAAAATGTCTTGGTTGTACCTGTTTGTGGCTTA
GCTTTGTATTTAAATAGCAAACAAAAAAAGGAAATAAACTTGAAACTTATTTGTCATCTTAAAA
ATAAAGCAAAAAAATTAAAGTATTTATTTCCAGGCAAGGGCA

hide sequence

RefSeq Acc Id:

XM_017598458 ⟹ XP_017453947

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	37,800,339 - 37,823,683 (-)	NCBI
mRatBN7.2	12	32,139,353 - 32,162,703 (-)	NCBI
Rnor_6.0	12	37,558,152 - 37,581,176 (-)	NCBI

Sequence:

show sequence

GCTACAGTTGTTGCAACTTTTTTCGAAAGCTGGGTTTCCCGGGAGATTCCAGACGGTGACAGAG
CGGGGCCATGGCTAGAGGAGAACGTGTTTGCTGGGCAGTCAAAGATCTATGCCTACATGAGTCC
GAACAAATGCTCTGGAATGCGTTCTCCACTGCAGGAAGAGAACTCCGTCGCACATCATGAGGTC
AAATGCCCGGGGAAACCATTGGCCGGAATCTACAGGAAGCGAGAAGAGAAAAGAAACGCTGGGA
ATGTTATCCGAAGCGCTGTGAAGTCAGAAGAACAGAAGAGCAAAGATACCAGGAGAGGTCCCCT
GGCGCCTTTTCCAAACCAAAAACCTGAAGCAACAGAACCTCCAAAAACTCCACCCCCGTCATGT
GATTCTACCAGTGTAGCGGTTGCTAAGCAAGCCCTGAAAAAGCCCCTCAAGGGCAAGCAGGCCC
CTCGGAAGAAGTCTCAAGGGAAGACACAGCAGAATAGAAAACTCACAGATTTCTACCCCGTGCG
AAGGAGCTCCAGGAAGAGCAAAGCTGAGCTGCAGTCTGAAGAAAGGAAGAAGATAGATGAGCTA
ATTGAGAGCGGGAAGGAAGAGGGCATGAAGATTGATCTAATCGATGGCAAAGGCAGGGGTGTGA
TTGCTACCAAGCGATTCTCCCGGGGAGACTTTGTGGTAGAATACCATGGAGACCTCATTGAAAT
CACCGATGCCAAGAAGCGGGAGGCTCTGTATGCACAGGACCCCTCCACGGGCTGCTACATGTAC
TATTTTCAATATCTGAGCAAAACCTACTGCGTGGATGCCACTCAAGAAACGAACCGCCTGGGGA
GACTGATCAATCACAGTAAGTGTGGGAATTGCCAGACCAAACTGCATGACATCGACGGCGTGCC
TCACCTCATCCTCATAGCCTCCCGAGACATTGCGGCCGGGGAGGAGCTCCTGTACGACTATGGA
GACCGGAGCAAGGCCTCCATCGAAGCCTACCCTTGGCTGAAGCACTAACCAACCATGTGGCCTC
CCTGCCTCCCTGCCACCCTGCCTCCTTCAAAGGACAAAGTGCCCTCAAAGGGAAATGAATTTTT
TACACACACACACACACACACACACACACACACACACACACACACACACACACTCACACTCACT
CTTAGCTAATTACTTCAAATGTTTTTAAAAAGTATATTAAAGATGCCTTTTCATGTAGTATTTA
AATATCTGTTACAGGTTTCCAAGGTGGACTTGAACAGATGGCCTTATATTACCAAAACTTTTAT
ATTCTAGTTGTTTTTCTACCTTTTTGCATACAAGCTGAACATTTGTGCTTCCCGCGCAGTGTAA
GACTCGGCACAGGTTTTAGAGAATGGAGTTGAACATGAACTAGGAAGCCGGGCTCTGCCCAAGA
TGAAAGCCAGGACTCCCCCGCACCCCACGTCCGAGGACAGGCCGGTGTGAGGGTGCTGCCACCC
CCACGCACAGCCTGGACGGGATGTCTCCAAGCTCTTGTTCTCCTCAACGTCTTGACAGGTGTAC
ACATTGACGTGTATGAATATTTTTTAGCAAAAGTTTCACAGTAAGCTAGTCTTCCCCTCTGCTT
TCTCCAAAGCTTACTGAGCCCGGGGCTCGGAGGCCCGGCCAGGAACAGACCTCTTCCACAGGCT
TACGGCTTTTCCAGGCACCTTGAAGCATCAGGGTGGGCAGTCAGACTAGAGGCGGGCCGGGAAA
AGCACTGTTCTCCTGCCCAAGAAGGGCAGGTCTCCTGAAACTGCATTAATTCTTTATAGAAATG
TGAACACTGAATTTATTTTAAAAAATAATAATAAAAAAACAAAATAGTAAAAAAAAATTTAAAA
AGAAAAAAAATGGAAAAAAAAAACCCACAGAAAACAACTTAACATGTATATAGGTTTTGAAGGG
AGTGAAATGAATGCAGTTTTCTTTTCTTCTGGGGTTTATTTTTCTTTTTGGCTTGGCTGGTTGG
TTTGTGTAGAGAAGATTTGAGATGGTACTCTATTCTAATCAAAAGTGAGGTTTGTAGTGGGACC
AGAAATTACTAAGCCCACACCCCCTCCCCAACCCCAATTCTGCTACGTGGGAAGTTCTCTACCT
GCTGTCAAGGCAGAACCCCTGGTCTCCCGTGAAGATGCCGTCAGTCCTGTGGGCATCAGACACC
AGATGTGTTTGGCTCTAGGGTACCTGGCAGCCCGCAAGGCTTAGCAGCCAGAGATCAGGAGGAT
CCTTCAGTTGTAACCTGTGATAGCAAGAGTAGGCTTCCTTCTCCCTCCTTGGGGAGGACTAACC
ATTCACCTTCAGTCCAGGGGGCCTGGGGTTCAGGAGCCAGGTGTAAGAGCCTACCCTTGTCCCC
AGTACCTCCATCTCCCAGCCTCATGATGGTGCTACCTAAGAAAGTCTTCCCCGCACCCTTTGCT
AGCCCAGTCAGTGGTCAGACTTGGAGGAGGATCCGACAGGAGGGTGTAACTGTGAGATAAAATG
TCTTGGTTGTACCTGTTTGTGGCTTAGCTTTGTATTTAAATAGCAAACAAAAAAAGGAAATAAA
CTTGAAACTTATTTGTCATCTTAAAAATAAAGCAAAAAAATTAAAGTATTTATTTCCAGGCAAG
GG

hide sequence

RefSeq Acc Id:

XM_039089771 ⟹ XP_038945699

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	37,800,339 - 37,823,537 (-)	NCBI
mRatBN7.2	12	32,139,353 - 32,162,626 (-)	NCBI

RefSeq Acc Id:

XM_039089773 ⟹ XP_038945701

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	37,800,339 - 37,818,610 (-)	NCBI
mRatBN7.2	12	32,139,353 - 32,157,614 (-)	NCBI

RefSeq Acc Id:

XM_063271675 ⟹ XP_063127745

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	37,800,339 - 37,819,376 (-)	NCBI

RefSeq Acc Id:

XM_063271676 ⟹ XP_063127746

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	37,800,339 - 37,817,566 (-)	NCBI

RefSeq Acc Id:

XM_063271677 ⟹ XP_063127747

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	37,800,339 - 37,817,774 (-)	NCBI

RefSeq Acc Id:

XM_063271679 ⟹ XP_063127749

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	37,800,339 - 37,823,683 (-)	NCBI

RefSeq Acc Id:

XR_010056419

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	37,802,938 - 37,817,566 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001233594	(Get FASTA)	NCBI Sequence Viewer
	NP_001400566	(Get FASTA)	NCBI Sequence Viewer
	XP_006249390	(Get FASTA)	NCBI Sequence Viewer
	XP_006249392	(Get FASTA)	NCBI Sequence Viewer
	XP_017453947	(Get FASTA)	NCBI Sequence Viewer
	XP_038945699	(Get FASTA)	NCBI Sequence Viewer
	XP_038945701	(Get FASTA)	NCBI Sequence Viewer
	XP_063127745	(Get FASTA)	NCBI Sequence Viewer
	XP_063127746	(Get FASTA)	NCBI Sequence Viewer
	XP_063127747	(Get FASTA)	NCBI Sequence Viewer
	XP_063127749	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAK43219	(Get FASTA)	NCBI Sequence Viewer
	EDM13586	(Get FASTA)	NCBI Sequence Viewer
	EDM13587	(Get FASTA)	NCBI Sequence Viewer
	EDM13588	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000062763.3
	ENSRNOP00000080894.1
	ENSRNOP00000084143.1
	ENSRNOP00000088749.1
	ENSRNOP00000092997.1
	ENSRNOP00000095821.1

RefSeq Acc Id:	NP_001233594 ⟸ NM_001246665
- Peptide Label:	isoform 1
- UniProtKB:	A0A8I5ZY89 (UniProtKB/TrEMBL)
- Sequence:	show sequence MVERRGPGRPRSDGENVFAGQSKIYAYMSPNKCSGMRSPLQEENSVAHHEVKCPGKPLAGIYRK REEKRNAGNVIRSAVKSEEQKSKDTRRGPLAPFPNQKPEATEPPKTPPPSCDSTSVAVAKQALK KPLKGKQAPRKKSQGKTQQNRKLTDFYPVRRSSRKSKAELQSEERKKIDELIESGKEEGMKIDL IDGKGRGVIATKRFSRGDFVVEYHGDLIEITDAKKREALYAQDPSTGCYMYYFQYLSKTYCVDA TQETNRLGRLINHSKCGNCQTKLHDIDGVPHLILIASRDIAAGEELLYDYGDRSKASIEAYPWL KH hide sequence

RefSeq Acc Id:	XP_006249390 ⟸ XM_006249328
- Peptide Label:	isoform X3
- UniProtKB:	A0A8J8XFN9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MARGRKMCKPRAVEAAAAAVAATAPGPEMVERRGPGRPRSDGENVFAGQSKIYAYMSPNKCSGM RSPLQEENSVAHHEVKCPGKPLAGIYRKREEKRNAGNVIRSAVKSEEQKSKDTRRGPLAPFPNQ KPEATEPPKTPPPSCDSTSVAVAKQALKKPLKGKQAPRKKSQGKTQQNRKLTDFYPVRRSSRKS KAELQSEERKKIDELIESGKEEGMKIDLIDGKGRGVIATKRFSRGDFVVEYHGDLIEITDAKKR EALYAQDPSTGCYMYYFQYLSKTYCVDATQETNRLGRLINHSKCGNCQTKLHDIDGVPHLILIA SRDIAAGEELLYDYGDRSKASIEAYPWLKH hide sequence

RefSeq Acc Id:	XP_006249392 ⟸ XM_006249330
- Peptide Label:	isoform X6
- UniProtKB:	A0A8I5ZQS7 (UniProtKB/TrEMBL), A6J0Z8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSPNKCSGMRSPLQEENSVAHHEVKCPGKPLAGIYRKREEKRNAGNVIRSAVKSEEQKSKDTRR GPLAPFPNQKPEATEPPKTPPPSCDSTSVAVAKQALKKPLKGKQAPRKKSQGKTQQNRKLTDFY PVRRSSRKSKAELQSEERKKIDELIESGKEEGMKIDLIDGKGRGVIATKRFSRGDFVVEYHGDL IEITDAKKREALYAQDPSTGCYMYYFQYLSKTYCVDATQETNRLGRLINHSKCGNCQTKLHDID GVPHLILIASRDIAAGEELLYDYGDRSKASIEAYPWLKH hide sequence

RefSeq Acc Id:	XP_017453947 ⟸ XM_017598458
- Peptide Label:	isoform X6
- UniProtKB:	A0A8I5ZQS7 (UniProtKB/TrEMBL), A6J0Z8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSPNKCSGMRSPLQEENSVAHHEVKCPGKPLAGIYRKREEKRNAGNVIRSAVKSEEQKSKDTRR GPLAPFPNQKPEATEPPKTPPPSCDSTSVAVAKQALKKPLKGKQAPRKKSQGKTQQNRKLTDFY PVRRSSRKSKAELQSEERKKIDELIESGKEEGMKIDLIDGKGRGVIATKRFSRGDFVVEYHGDL IEITDAKKREALYAQDPSTGCYMYYFQYLSKTYCVDATQETNRLGRLINHSKCGNCQTKLHDID GVPHLILIASRDIAAGEELLYDYGDRSKASIEAYPWLKH hide sequence

Ensembl Acc Id:

ENSRNOP00000062763 ⟸ ENSRNOT00000066253

RefSeq Acc Id:	XP_038945699 ⟸ XM_039089771
- Peptide Label:	isoform X4
- UniProtKB:	F7J138 (UniProtKB/TrEMBL), D3ZEB9 (UniProtKB/TrEMBL), A0A8J8XFN9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038945701 ⟸ XM_039089773
- Peptide Label:	isoform X5
- UniProtKB:	A0A8I5ZY89 (UniProtKB/TrEMBL), A0A8J8XFN9 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000080894 ⟸ ENSRNOT00000114055

Ensembl Acc Id:

ENSRNOP00000088749 ⟸ ENSRNOT00000111843

Ensembl Acc Id:

ENSRNOP00000084143 ⟸ ENSRNOT00000106166

Ensembl Acc Id:

ENSRNOP00000095821 ⟸ ENSRNOT00000106064

Ensembl Acc Id:

ENSRNOP00000092997 ⟸ ENSRNOT00000108981

RefSeq Acc Id:	NP_001400566 ⟸ NM_001413637
- Peptide Label:	isoform 2
- UniProtKB:	A0A8I6GKG3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063127749 ⟸ XM_063271679
- Peptide Label:	isoform X7

RefSeq Acc Id:	XP_063127745 ⟸ XM_063271675
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_063127747 ⟸ XM_063271677
- Peptide Label:	isoform X5
- UniProtKB:	A0A8I5ZY89 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063127746 ⟸ XM_063271676
- Peptide Label:	isoform X2

Protein Domains

SET

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZEB9-F1-model_v2	AlphaFold	D3ZEB9	1-322	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1587560	AgrOrtholog
BioCyc Gene	G2FUF-19354	BioCyc
Ensembl Genes	ENSRNOG00000001062	Ensembl
	ENSRNOG00000064318	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000066253.3	UniProtKB/TrEMBL
	ENSRNOT00000106064.1	UniProtKB/TrEMBL
	ENSRNOT00000106166.1	UniProtKB/TrEMBL
	ENSRNOT00000108981.1	UniProtKB/TrEMBL
	ENSRNOT00000111843.1	UniProtKB/TrEMBL
	ENSRNOT00000114055.1	UniProtKB/TrEMBL
Gene3D-CATH	2.170.270.10	UniProtKB/TrEMBL
InterPro	Hist_H4-K20_MeTrfase	UniProtKB/TrEMBL
	KMT5A	UniProtKB/TrEMBL
	KMT5A-like_SET	UniProtKB/TrEMBL
	SET_dom	UniProtKB/TrEMBL
	SET_dom_sf	UniProtKB/TrEMBL
KEGG Report	rno:689820	UniProtKB/TrEMBL
NCBI Gene	689820	ENTREZGENE
PANTHER	N-LYSINE METHYLTRANSFERASE KMT5A	UniProtKB/TrEMBL
	N-LYSINE METHYLTRANSFERASE KMT5A	UniProtKB/TrEMBL
Pfam	SET	UniProtKB/TrEMBL
PhenoGen	Kmt5a	PhenoGen
PIRSF	Histone_H4-K20_mtfrase	UniProtKB/TrEMBL
PROSITE	SAM_MT43_7	UniProtKB/TrEMBL
	SET	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000001062	RatGTEx
	ENSRNOG00000064318	RatGTEx
SMART	SET	UniProtKB/TrEMBL
Superfamily-SCOP	SSF82199	UniProtKB/TrEMBL
UniProt	A0A8I5ZQS7	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5ZY89	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6A5Q1_RAT	UniProtKB/TrEMBL
	A0A8I6ANW6_RAT	UniProtKB/TrEMBL
	A0A8I6GKG3	ENTREZGENE, UniProtKB/TrEMBL
	A0A8J8XFN9	ENTREZGENE, UniProtKB/TrEMBL
	A6J0Z8	ENTREZGENE, UniProtKB/TrEMBL
	D3ZEB9	ENTREZGENE, UniProtKB/TrEMBL
	F7J138	ENTREZGENE
UniProt Secondary	F7J138	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-17	Kmt5a	lysine methyltransferase 5A	Kmt5a	lysine (K)-specific methyltransferase 5A	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2015-11-13	Kmt5a	lysine (K)-specific methyltransferase 5A	Setd8	SET domain containing (lysine methyltransferase) 8	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2009-06-15	Setd8	SET domain containing (lysine methyltransferase) 8	LOC687538	similar to SET domain-containing protein	Data merged from RGD:1584227	1643240	APPROVED
2009-01-26	Setd8	SET domain containing (lysine methyltransferase) 8	LOC689820	similar to SET domain-containing protein	Symbol and Name updated	1299863	APPROVED
2006-11-19	LOC689820	similar to SET domain-containing protein			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-11-19	LOC687538	similar to SET domain-containing protein			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)