Mettl21cl1 (methyltransferase like 21C-like 1) - Rat Genome Database

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Gene: Mettl21cl1 (methyltransferase like 21C-like 1) Rattus norvegicus
Analyze
Symbol: Mettl21cl1
Name: methyltransferase like 21C-like 1
RGD ID: 1596736
Description: Predicted to enable protein-lysine N-methyltransferase activity. Predicted to be part of protein-containing complex. Predicted to be active in cytosol. Orthologous to human METTL21EP (methyltransferase like 21E, pseudogene); INTERACTS WITH bisphenol A; trichloroethene; aristolochic acid A (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC681354; protein-lysine methyltransferase METTL21E; similar to RIKEN cDNA 4832428D23
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8953,872,602 - 53,889,356 (+)NCBIGRCr8
mRatBN7.2946,382,141 - 46,397,299 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl946,383,687 - 46,397,266 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0950,998,401 - 51,013,433 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl951,009,116 - 51,013,356 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0950,665,768 - 50,703,174 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4943,323,068 - 43,336,647 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera944,085,243 - 44,100,486 (+)NCBICelera
Cytogenetic Map9q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
methylation  (IEA)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Mettl21cl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8953,872,602 - 53,889,356 (+)NCBIGRCr8
mRatBN7.2946,382,141 - 46,397,299 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl946,383,687 - 46,397,266 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0950,998,401 - 51,013,433 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl951,009,116 - 51,013,356 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0950,665,768 - 50,703,174 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4943,323,068 - 43,336,647 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera944,085,243 - 44,100,486 (+)NCBICelera
Cytogenetic Map9q22NCBI
METTL21EP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813102,880,099 - 102,896,033 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl13102,880,040 - 102,896,033 (+)EnsemblGRCh38hg38GRCh38
GRCh3713103,532,449 - 103,548,383 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3613102,341,011 - 102,347,044 (+)NCBINCBI36Build 36hg18NCBI36
Celera1384,376,936 - 84,392,873 (+)NCBICelera
Cytogenetic Map13q33.1NCBI
HuRef1384,124,685 - 84,140,625 (+)NCBIHuRef
CHM1_113103,501,907 - 103,517,838 (+)NCBICHM1_1
T2T-CHM13v2.013102,098,307 - 102,114,246 (+)NCBIT2T-CHM13v2.0
Mettl21e
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39144,238,651 - 44,258,260 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl144,243,230 - 44,258,121 (-)EnsemblGRCm39 Ensembl
GRCm38144,204,070 - 44,218,931 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl144,204,070 - 44,218,961 (-)EnsemblGRCm38mm10GRCm38
MGSCv37144,260,915 - 44,275,776 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36144,148,616 - 44,163,477 (-)NCBIMGSCv36mm8
Celera144,548,875 - 44,563,804 (-)NCBICelera
Cytogenetic Map1C1.1NCBI
cM Map123.63NCBI
LOC100855548
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12252,373,716 - 52,392,656 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2252,153,364 - 52,175,488 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02252,821,486 - 52,844,008 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12252,473,871 - 52,573,275 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02252,490,234 - 52,512,756 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02252,531,299 - 52,553,821 (+)NCBIUU_Cfam_GSD_1.0
LOC102165734
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1171,174,395 - 71,192,224 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11171,173,756 - 71,202,234 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21178,519,248 - 78,542,472 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Mettl21cl1
51 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:34
Count of miRNA genes:33
Interacting mature miRNAs:34
Transcripts:ENSRNOT00000039313
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)92375402461381613Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)92375402458157242Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)92213332249968732Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)92746863972468639Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
6 10 25 99 47 48 20 19 20 6 130 64 81 32 52 28

Sequence


Ensembl Acc Id: ENSRNOT00000039313   ⟹   ENSRNOP00000032001
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl946,383,687 - 46,397,266 (+)Ensembl
Rnor_6.0 Ensembl951,009,116 - 51,013,356 (+)Ensembl
RefSeq Acc Id: XM_001061373   ⟹   XP_001061373
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8953,872,602 - 53,889,356 (+)NCBI
mRatBN7.2946,382,141 - 46,397,299 (+)NCBI
Rnor_6.0950,998,401 - 51,013,433 (+)NCBI
Rnor_5.0950,665,768 - 50,703,174 (+)NCBI
RGSC_v3.4943,323,068 - 43,336,647 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs XP_001061373 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000032001.5
RefSeq Acc Id: XP_001061373   ⟸   XM_001061373
- UniProtKB: F1M0X4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000032001   ⟸   ENSRNOT00000039313

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M0X4-F1-model_v2 AlphaFold F1M0X4 1-229 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1596736 AgrOrtholog
BioCyc Gene G2FUF-27649 BioCyc
Ensembl Genes ENSRNOG00000022762 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000039313.5 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.150 UniProtKB/TrEMBL
InterPro Nicotinamide_N-MeTfrase-like UniProtKB/TrEMBL
  SAM-dependent_MTases-like UniProtKB/TrEMBL
NCBI Gene 681354 ENTREZGENE
PANTHER METHYLTRANSFERASE-LIKE PROTEIN 21E PSEUDOGENE-RELATED UniProtKB/TrEMBL
  PTHR14614 UniProtKB/TrEMBL
Pfam Methyltransf_16 UniProtKB/TrEMBL
PhenoGen Mettl21cl1 PhenoGen
RatGTEx ENSRNOG00000022762 RatGTEx
Superfamily-SCOP SSF53335 UniProtKB/TrEMBL
UniProt F1M0X4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-01 Mettl21cl1  methyltransferase like 21C-like 1  LOC681354  similar to RIKEN cDNA 4832428D23  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC681354  similar to RIKEN cDNA 4832428D23      Symbol and Name status set to provisional 70820 PROVISIONAL