Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Setd4 | Rat | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of SETD4 mRNA] | CTD | PMID:31150632 | Setd4 | Rat | (1->4)-beta-D-glucan | multiple interactions | ISO | Setd4 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of SETD4 mRNA | CTD | PMID:36331819 | Setd4 | Rat | 1,2-dichloroethane | decreases expression | ISO | Setd4 (Mus musculus) | 6480464 | ethylene dichloride results in decreased expression of SETD4 mRNA | CTD | PMID:28960355 | Setd4 | Rat | 1,2-dimethylhydrazine | increases expression | ISO | Setd4 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of SETD4 mRNA | CTD | PMID:22206623 | Setd4 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Setd4 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SETD4 mRNA | CTD | PMID:19770486 | Setd4 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Setd4 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of SETD4 mRNA | CTD | PMID:21570461 | Setd4 | Rat | 3,3',4,4'-tetrachlorobiphenyl | multiple interactions | ISO | Setd4 (Mus musculus) | 6480464 | 3 more ... | CTD | PMID:19467301 | Setd4 | Rat | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | SETD4 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SETD4 mRNA | CTD | PMID:28628672 | Setd4 | Rat | 4,4'-diaminodiphenylmethane | decreases expression | ISO | Setd4 (Mus musculus) | 6480464 | 4 and 4'-diaminodiphenylmethane results in decreased expression of SETD4 mRNA | CTD | PMID:18648102 | Setd4 | Rat | 4,4'-sulfonyldiphenol | decreases methylation | ISO | Setd4 (Mus musculus) | 6480464 | bisphenol S results in decreased methylation of SETD4 exon | CTD | PMID:33297965 | Setd4 | Rat | 4,4'-sulfonyldiphenol | affects methylation | ISO | Setd4 (Mus musculus) | 6480464 | bisphenol S affects the methylation of SETD4 gene | CTD | PMID:31683443 | Setd4 | Rat | acetaldehyde | increases expression | ISO | SETD4 (Homo sapiens) | 6480464 | Acetaldehyde results in increased expression of SETD4 mRNA | CTD | PMID:23416264 | Setd4 | Rat | aflatoxin B1 | increases expression | ISO | Setd4 (Mus musculus) | 6480464 | Aflatoxin B1 results in increased expression of SETD4 mRNA | CTD | PMID:19770486 | Setd4 | Rat | all-trans-retinoic acid | decreases expression | ISO | SETD4 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of SETD4 mRNA | CTD | PMID:33167477 | Setd4 | Rat | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of SETD4 mRNA | CTD | PMID:16483693 | Setd4 | Rat | aristolochic acid A | increases expression | ISO | SETD4 (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of SETD4 mRNA | CTD | PMID:33212167 | Setd4 | Rat | benzo[a]pyrene | increases expression | ISO | Setd4 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of SETD4 mRNA | CTD | PMID:19770486 and PMID:21715664 | Setd4 | Rat | benzo[a]pyrene | decreases expression | ISO | Setd4 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of SETD4 mRNA | CTD | PMID:22228805 | Setd4 | Rat | bisphenol A | decreases expression | ISO | SETD4 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of SETD4 mRNA | CTD | PMID:20678512 | Setd4 | Rat | bisphenol A | increases methylation | ISO | SETD4 (Homo sapiens) | 6480464 | bisphenol A results in increased methylation of SETD4 gene | CTD | PMID:31601247 | Setd4 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of SETD4 mRNA | CTD | PMID:25181051 | Setd4 | Rat | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Testosterone] results in increased expression of SETD4 mRNA | CTD | PMID:26496021 | Setd4 | Rat | bisphenol F | multiple interactions | ISO | SETD4 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SETD4 mRNA | CTD | PMID:28628672 | Setd4 | Rat | bisphenol F | decreases expression | ISO | Setd4 (Mus musculus) | 6480464 | bisphenol F results in decreased expression of SETD4 mRNA | CTD | PMID:38685157 | Setd4 | Rat | cadmium atom | multiple interactions | ISO | SETD4 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SETD4 mRNA | CTD | PMID:35301059 | Setd4 | Rat | cadmium dichloride | decreases expression | ISO | SETD4 (Homo sapiens) | 6480464 | Cadmium Chloride results in decreased expression of SETD4 mRNA | CTD | PMID:38568856 | Setd4 | Rat | cadmium dichloride | multiple interactions | ISO | SETD4 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SETD4 mRNA | CTD | PMID:35301059 | Setd4 | Rat | carbon nanotube | decreases expression | ISO | Setd4 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25620056 | Setd4 | Rat | CGP 52608 | multiple interactions | ISO | SETD4 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to SETD4 gene] | CTD | PMID:28238834 | Setd4 | Rat | chlorpyrifos | decreases expression | ISO | Setd4 (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of SETD4 mRNA | CTD | PMID:37019170 | Setd4 | Rat | clofibrate | decreases expression | ISO | Setd4 (Mus musculus) | 6480464 | Clofibrate results in decreased expression of SETD4 mRNA | CTD | PMID:23811191 | Setd4 | Rat | cobalt dichloride | increases expression | EXP | | 6480464 | cobaltous chloride results in increased expression of SETD4 mRNA | CTD | PMID:24386269 | Setd4 | Rat | copper(II) sulfate | decreases expression | ISO | SETD4 (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of SETD4 mRNA | CTD | PMID:19549813 | Setd4 | Rat | crocidolite asbestos | decreases expression | ISO | SETD4 (Homo sapiens) | 6480464 | Asbestos and Crocidolite results in decreased expression of SETD4 mRNA | CTD | PMID:25351596 | Setd4 | Rat | cyclosporin A | increases expression | ISO | Setd4 (Mus musculus) | 6480464 | Cyclosporine results in increased expression of SETD4 mRNA | CTD | PMID:19770486 | Setd4 | Rat | dexamethasone | multiple interactions | ISO | SETD4 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SETD4 mRNA | CTD | PMID:28628672 | Setd4 | Rat | Dibutyl phosphate | affects expression | ISO | SETD4 (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of SETD4 mRNA | CTD | PMID:37042841 | Setd4 | Rat | dibutyl phthalate | decreases expression | ISO | Setd4 (Mus musculus) | 6480464 | Dibutyl Phthalate results in decreased expression of SETD4 mRNA | CTD | PMID:21266533 | Setd4 | Rat | dicrotophos | decreases expression | ISO | SETD4 (Homo sapiens) | 6480464 | dicrotophos results in decreased expression of SETD4 mRNA | CTD | PMID:28302478 | Setd4 | Rat | epoxiconazole | increases expression | ISO | Setd4 (Mus musculus) | 6480464 | epoxiconazole results in increased expression of SETD4 mRNA | CTD | PMID:35436446 | Setd4 | Rat | fipronil | increases expression | EXP | | 6480464 | fipronil results in increased expression of SETD4 mRNA | CTD | PMID:31881178 | Setd4 | Rat | flavonoids | decreases expression | EXP | | 6480464 | Flavonoids results in decreased expression of SETD4 mRNA | CTD | PMID:18035473 | Setd4 | Rat | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of SETD4 mRNA | CTD | PMID:24136188 | Setd4 | Rat | indometacin | multiple interactions | ISO | SETD4 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SETD4 mRNA | CTD | PMID:28628672 | Setd4 | Rat | L-methionine | decreases expression | ISO | Setd4 (Mus musculus) | 6480464 | Methionine deficiency results in decreased expression of SETD4 mRNA and Methionine results in decreased expression of SETD4 mRNA | CTD | PMID:35314295 | Setd4 | Rat | leflunomide | increases expression | EXP | | 6480464 | leflunomide results in increased expression of SETD4 mRNA | CTD | PMID:24136188 | Setd4 | Rat | nefazodone | increases expression | EXP | | 6480464 | nefazodone results in increased expression of SETD4 mRNA | CTD | PMID:24136188 | Setd4 | Rat | nimesulide | increases expression | EXP | | 6480464 | nimesulide results in increased expression of SETD4 mRNA | CTD | PMID:24136188 | Setd4 | Rat | pentachlorophenol | increases expression | ISO | Setd4 (Mus musculus) | 6480464 | Pentachlorophenol results in increased expression of SETD4 mRNA | CTD | PMID:23892564 | Setd4 | Rat | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Setd4 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of SETD4 mRNA | CTD | PMID:36331819 | Setd4 | Rat | phenobarbital | increases expression | ISO | Setd4 (Mus musculus) | 6480464 | Phenobarbital results in increased expression of SETD4 mRNA | CTD | PMID:19270015 | Setd4 | Rat | phenobarbital | affects expression | ISO | Setd4 (Mus musculus) | 6480464 | Phenobarbital affects the expression of SETD4 mRNA | CTD | PMID:23091169 | Setd4 | Rat | piperonyl butoxide | increases expression | EXP | | 6480464 | Piperonyl Butoxide results in increased expression of SETD4 mRNA | CTD | PMID:22484513 | Setd4 | Rat | pirinixic acid | increases expression | ISO | Setd4 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of SETD4 mRNA | CTD | PMID:18301758 | Setd4 | Rat | silicon dioxide | decreases expression | ISO | Setd4 (Mus musculus) | 6480464 | Silicon Dioxide results in decreased expression of SETD4 mRNA | CTD | PMID:23221170 | Setd4 | Rat | silicon dioxide | decreases expression | ISO | SETD4 (Homo sapiens) | 6480464 | Silicon Dioxide results in decreased expression of SETD4 mRNA | CTD | PMID:25351596 | Setd4 | Rat | sodium arsenate | decreases expression | ISO | Setd4 (Mus musculus) | 6480464 | sodium arsenate results in decreased expression of SETD4 mRNA | CTD | PMID:30953684 | Setd4 | Rat | sodium arsenite | decreases expression | ISO | SETD4 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of SETD4 mRNA | CTD | PMID:38568856 | Setd4 | Rat | sodium dichromate | increases expression | EXP | | 6480464 | sodium bichromate results in increased expression of SETD4 mRNA | CTD | PMID:25993096 | Setd4 | Rat | succimer | multiple interactions | ISO | Setd4 (Mus musculus) | 6480464 | [Succimer binds to Magnetite Nanoparticles] which results in increased expression of SETD4 mRNA | CTD | PMID:21641980 | Setd4 | Rat | testosterone | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Testosterone] results in increased expression of SETD4 mRNA | CTD | PMID:26496021 | Setd4 | Rat | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of SETD4 mRNA | CTD | PMID:31150632 | Setd4 | Rat | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of SETD4 mRNA] | CTD | PMID:31150632 | Setd4 | Rat | tetraphene | increases expression | ISO | Setd4 (Mus musculus) | 6480464 | benz(a)anthracene results in increased expression of SETD4 mRNA | CTD | PMID:26377693 | Setd4 | Rat | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of SETD4 mRNA | CTD | PMID:23411599 | Setd4 | Rat | titanium dioxide | increases methylation | ISO | Setd4 (Mus musculus) | 6480464 | titanium dioxide results in increased methylation of SETD4 gene | CTD | PMID:35295148 | Setd4 | Rat | valdecoxib | increases expression | EXP | | 6480464 | valdecoxib results in increased expression of SETD4 mRNA | CTD | PMID:24136188 | Setd4 | Rat | valproic acid | decreases expression | ISO | Setd4 (Mus musculus) | 6480464 | Valproic Acid results in decreased expression of SETD4 mRNA | CTD | PMID:21427059 | |