Eef1akmt4 (EEF1A lysine methyltransferase 4) - Rat Genome Database

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Gene: Eef1akmt4 (EEF1A lysine methyltransferase 4) Rattus norvegicus
Analyze
Symbol: Eef1akmt4
Name: EEF1A lysine methyltransferase 4
RGD ID: 7732114
Description: Predicted to enable protein-lysine N-methyltransferase activity. Predicted to be involved in methylation. Orthologous to human EEF1AKMT4 (EEF1A lysine methyltransferase 4); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: endothelin-converting enzyme 2; endothelin-converting enzyme 2-like; LOC102551435
RGD Orthologs
Human
Mouse
Bonobo
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81193,796,506 - 93,804,061 (-)NCBIGRCr8
mRatBN7.21180,292,113 - 80,299,670 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1180,291,978 - 80,299,659 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1189,014,805 - 89,022,341 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01181,668,224 - 81,675,760 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01180,729,289 - 80,736,825 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01183,977,841 - 83,985,429 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1183,977,664 - 83,985,385 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01187,050,168 - 87,057,767 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
methylation  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:28391595   PMID:28520920   PMID:28887308  


Genomics

Comparative Map Data
Eef1akmt4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81193,796,506 - 93,804,061 (-)NCBIGRCr8
mRatBN7.21180,292,113 - 80,299,670 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1180,291,978 - 80,299,659 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1189,014,805 - 89,022,341 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01181,668,224 - 81,675,760 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01180,729,289 - 80,736,825 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01183,977,841 - 83,985,429 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1183,977,664 - 83,985,385 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01187,050,168 - 87,057,767 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Cytogenetic Map11q23NCBI
EEF1AKMT4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383184,249,672 - 184,258,759 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3184,249,672 - 184,258,759 (+)EnsemblGRCh38hg38GRCh38
GRCh373183,967,460 - 183,976,547 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map3q27.1NCBI
T2T-CHM13v2.03187,058,960 - 187,068,061 (+)NCBIT2T-CHM13v2.0
Eef1akmt4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391620,430,351 - 20,437,619 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1620,430,343 - 20,437,761 (+)EnsemblGRCm39 Ensembl
GRCm381620,611,601 - 20,618,869 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1620,611,593 - 20,619,011 (+)EnsemblGRCm38mm10GRCm38
Cytogenetic Map16A3NCBI
EEF1AKMT4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22182,120,030 - 182,129,217 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13182,124,866 - 182,133,934 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03181,284,203 - 181,293,301 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13189,766,786 - 189,775,958 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3189,766,786 - 189,811,206 (+)Ensemblpanpan1.1panPan2
EEF1AKMT4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1155,166,130 - 5,175,717 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl155,163,387 - 5,175,200 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606313,943,352 - 13,952,498 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Eef1akmt4
9 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:133
Count of miRNA genes:102
Interacting mature miRNAs:107
Transcripts:ENSRNOT00000002334
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116611332182169223Rat
10450831Scl80Serum cholesterol level QTL 804.70.01blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)117695713183051965Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116944607082846715Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000002334   ⟹   ENSRNOP00000002334
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1180,291,978 - 80,299,659 (-)Ensembl
Rnor_6.0 Ensembl1183,977,664 - 83,985,385 (-)Ensembl
RefSeq Acc Id: NM_001399450   ⟹   NP_001386379
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81193,796,506 - 93,804,061 (-)NCBI
mRatBN7.21180,292,113 - 80,299,670 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001386379 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000002334.5
Ensembl Acc Id: ENSRNOP00000002334   ⟸   ENSRNOT00000002334
RefSeq Acc Id: NP_001386379   ⟸   NM_001399450
- UniProtKB: D4ADU7 (UniProtKB/TrEMBL)
Protein Domains
Methyltransferase type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4ADU7-F1-model_v2 AlphaFold D4ADU7 1-255 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698283
Promoter ID:EPDNEW_R8800
Type:multiple initiation site
Name:LOC102551435_1
Description:endothelin-converting enzyme 2-like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01183,985,382 - 83,985,442EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:7732114 AgrOrtholog
BioCyc Gene G2FUF-20742 BioCyc
Ensembl Genes ENSRNOG00000029529 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002334.8 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.150 UniProtKB/TrEMBL
InterPro Lys/N-term_MeTrsfase_sf UniProtKB/TrEMBL
  Methyltransf_11 UniProtKB/TrEMBL
  SAM-dependent_MTases-like UniProtKB/TrEMBL
NCBI Gene LOC102551435 ENTREZGENE
PANTHER EEF1A LYSINE METHYLTRANSFERASE 4 UniProtKB/TrEMBL
  SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN UniProtKB/TrEMBL
Pfam Methyltransf_11 UniProtKB/TrEMBL
PhenoGen Eef1akmt4 PhenoGen
RatGTEx ENSRNOG00000029529 RatGTEx
Superfamily-SCOP SSF53335 UniProtKB/TrEMBL
UniProt D4ADU7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-10-16 Eef1akmt4  EEF1A lysine methyltransferase 4  LOC102551435  endothelin-converting enzyme 2-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-12-18 LOC102551435  endothelin-converting enzyme 2-like      Symbol and Name status set to provisional 70820 PROVISIONAL