Macrocyclic lactones are chemical compounds that represent the main treatment for
parasitic diseases of animals, not only for helminth infections, but also a number of major …

Macrocyclic lactones (MLs) have many anti-parasitic applications in small companion
animal medicine. They were first developed as chemoprophylactics against heartworm …

The macrocyclic lactones have pharmacokinetic properties which enhance their use against
endo-and ectoparasites in animals and man. The most consistent physico-chemical feature …

Macrocyclic lactones are frequently used dewormers in livestock farms around the world.
Due to their wide spectrum of action against nematodes and arthropods and their practicality …

Macrocyclic lactones (MLs), exemplified by the prototype of the class, ivermectin (IVM), are
mainstays of programs for the control of nematode and arthropod parasites and pests. Since …

We studied the in vitro distribution of macrocyclic lactones (MLs), lipophilic anthelmintic
drugs, in the plasma of several animal species including humans. First, in vitro spiking of …

In the early 1960s our laboratory was engaged in a research program designed to find a
superior anthelmintic drug. We wanted it to be chemically unrelated to known drugs, potent …

Efforts to control the spectrum of diseases that affect humans, our crops and our animals
pose problems which need to be debated opealy. Widespread use of chemicals in such a …

There are three major classes of anthelmintics for veterinary use: the benzimidazoles/
prebenzimidazoles, the tetrahydropyrimidines/imidazothiazoles, and the macrocyclic …

Although there has been extensive veterinary focus on both the effectiveness of macrocyclic
lactones for heartworm prevention in dogs and their adulticidal effects, little attention has …