… mice expressing human APOE4 showing significance of induction of ABCA1, ABCG1, APOE,
and … (13,15) The role of ABCA1 in AD extends beyond Aβ clearance and includes roles in …

… progression of Alzheimer’s disease and related Dementias (… Apolipoprotein E (APOE) is
a 299 amino acid glycoprotein that exists in 3 different isoforms: APOE-ε2, APOE-ε3, and APOE…

… risk factors and disease among the Framingham Offspring during 2004-2009. HTN
hypertension, CAD coronary artery disease, CVA clinical stroke or TIA, AD Alzheimer'd disease …

… phase of disease. The extensive preclinical disease course of Alzheimer’s disease warrants
… participants for neuroprotective trials, and disease monitoring in trials and clinical practice. …

… ’s disease and related dementia (ADRD), focusing on those that have been approved or
progressed to Phase 2/3 or beyond … of the APOE ε2 allele are now being considered as disease-…

… HSD indicated significant differences in MMSE, AVLT, and APOE status. There was no …
in MCI stage, however transentorhinal connectivity is beyond the scope of this specific study. …

… Body composition as a potential biomarker in Alzheimer’s disease … Development of
Alzheimer’s disease phenotype as a consequence of a multisteppathological cascade activated by …

… individuals who possess the APOE ε4 allele, as those with T2DM and are also APOE ε4
carriers have twice the risk of developing AD compared to non-diabetic APOE ε4 carriers (Peila …

… cognitive decline in patients with neurodegenerative disorders such as Alzheimer's disease
(AD) (23), and biomarkers of AD such as the apolipoprotein E4 (APOE-4) genotype have …

… function for 5 regions, including three regions centromeric to MAPT beyond the H1/H2 …
APOE has been shown to regulate Aβ metabolism both directly and indirectly. APOE binds to Aβ …