Cyclin-dependent kinases 4 and 6 (CDK4/6) are fundamental drivers of the cell cycle and are
required for the initiation and progression of various malignancies 1 , 2 . Pharmacological …

Noble metal electrocatalysts (eg, Pt, Ru, etc.) suffer from sluggish kinetics of water dissociation
for the electrochemical reduction of water to molecular hydrogen in alkaline and neutral …

Background Patients with critical illness due to infection with the 2019 coronavirus disease (COVID-19)
show rapid disease progression to acute respiratory failure. The study aimed to …

Parasitic nematodes that cause elephantiasis and river blindness threaten hundreds of
millions of people in the developing world. We have sequenced the ∼90 megabase (Mb) …

Background The epigenetic regulation of immune response has been demonstrated in recent
studies. Nonetheless, potential roles of RNA N6-methyladenosine (m 6 A) modification in …

Over the past several years, significant advances have been made in developing the discontinuous
Galerkin finite element method for applications in fluid flow and heat transfer. Certain …

PARP inhibitors have shown promising clinical activities for patients with BRCA mutations
and are changing the landscape of ovarian cancer treatment. However, the therapeutic …

Background Severe ill patients with 2019 novel coronavirus (2019-nCoV) infection progressed
rapidly to acute respiratory failure. We aimed to select the most useful prognostic factor …

IL-17-producing T cells (Th17) have recently been implicated in the pathogenesis of
experimental autoimmune encephalomyelitis (EAE), an animal model for the human disease …

Genomic landscapes of 92 adult and 111 pediatric patients with B-cell acute lymphoblastic
leukemia (B-ALL) were investigated using next-generation sequencing and copy number …