Computational models of electrical activity and calcium signaling in cardiac myocytes are
important tools for understanding physiology. The sensitivity of these models to changes in …

A Ca 2+ spark arises when a cluster of sarcoplasmic reticulum (SR) channels (ryanodine
receptors or RyRs) opens to release calcium in a locally regenerative manner. Normally …

Heart muscle is characterized by a regular array of proteins and structures that form a repeating
functional unit identified as the sarcomere. This regular structure enables tight coupling …

Ca 2+ efflux from the sarcoplasmic reticulum (SR) is routed primarily through SR Ca 2+ release
channels (ryanodine receptors, RyRs). When clusters of RyRs are activated by trigger Ca …

The Library of Integrated Network-Based Cellular Signatures (LINCS) is an NIH Common
Fund program that catalogs how human cells globally respond to chemical, genetic, and …

A major challenge in computational biology is constraining free parameters in mathematical
models. Adjusting a parameter to make a given model output more realistic sometimes has …

To fully understand the mechanisms of defibrillation, it is critical to know how a given electrical
stimulus causes membrane polarizations in cardiac tissue. We have extended the concept …

Excitation–contraction coupling in the heart depends on the positive feedback process of
Ca 2 + ‐induced Ca 2 + release (CICR). While CICR provides for robust triggering of Ca 2 + …

Across individuals within a population, several levels of variability are observed, from the
differential expression of ion channels at the molecular level, to the various action potential …

Evidence that some high-impact biomedical results cannot be repeated has stimulated interest
in practices that generate findable, accessible, interoperable, and reusable (FAIR) data. …