Airway smooth muscle growth contributes to the mechanism of airway hyperresponsiveness
(AHR) in asthma. Although current steroid use demonstrates anti-inflammatory activity, there
is little reported on the action of corticosteroid on smooth muscle of the asthmatic airway.
The present study investigated the effect of inhaled corticosteroid on the thickening of airway
smooth muscle in bronchial asthma. We developed a mouse model of airway remodeling
including smooth muscle thickening in which ovalbumin (OVA)-sensitized female BALB/c …