Plasma clusterin and the risk of Alzheimer disease
EMC Schrijvers, PJ Koudstaal, A Hofman… - Jama, 2011 - jamanetwork.com
Context Variants in the clusterin gene are associated with the risk of Alzheimer disease (AD)
and clusterin levels have been found to be increased in brain and cerebrospinal fluid of
patients with AD. Plasma clusterin was reported to be associated with brain atrophy,
baseline disease severity, and rapid clinical progression in patients with AD. Objective To
evaluate the potential of plasma clusterin as a biomarker of the presence, severity, and risk
of AD. Design, Setting, and Participants A case-cohort study nested within the Rotterdam …
and clusterin levels have been found to be increased in brain and cerebrospinal fluid of
patients with AD. Plasma clusterin was reported to be associated with brain atrophy,
baseline disease severity, and rapid clinical progression in patients with AD. Objective To
evaluate the potential of plasma clusterin as a biomarker of the presence, severity, and risk
of AD. Design, Setting, and Participants A case-cohort study nested within the Rotterdam …
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