Transverse aortic constriction multi-omics analysis uncovers pathophysiological cardiac molecular mechanisms
E Gjerga, M Dewenter, T Britto-Borges, J Grosso… - Database, 2024 - academic.oup.com
Time-course multi-omics data of a murine model of progressive heart failure (HF) induced by
transverse aortic constriction (TAC) provide insights into the molecular mechanisms that are
causatively involved in contractile failure and structural cardiac remodelling. We employ
Illumina-based transcriptomics, Nanopore sequencing and mass spectrometry-based
proteomics on samples from the left ventricle (LV) and right ventricle (RV, RNA only) of the
heart at 1, 7, 21 and 56 days following TAC and Sham surgery. Here, we present Transverse …
transverse aortic constriction (TAC) provide insights into the molecular mechanisms that are
causatively involved in contractile failure and structural cardiac remodelling. We employ
Illumina-based transcriptomics, Nanopore sequencing and mass spectrometry-based
proteomics on samples from the left ventricle (LV) and right ventricle (RV, RNA only) of the
heart at 1, 7, 21 and 56 days following TAC and Sham surgery. Here, we present Transverse …
Transverse Aortic COnstriction Multi-omics Analysis (TACOMA) uncovers pathophysiological cardiac molecular mechanisms
E Gjerga, M Dewenter, T Britto-Borges, J Grosso… - bioRxiv, 2024 - biorxiv.org
Time-course multi-omics data of a murine model of progressive heart failure induced by
transverse aortic constriction (TAC) provide insights into the molecular mechanisms that are
causatively involved in contractile failure and structural cardiac remodelling. We employ
Illumina-based transcriptomics, Nanopore sequencing, and mass spectrometry-based
proteomics on samples from the left ventricle (LV) and right ventricle (RV, RNA only) of the
heart at 1, 7, 21, and 56 days following TAC and Sham surgery. Here, we present TACOMA …
transverse aortic constriction (TAC) provide insights into the molecular mechanisms that are
causatively involved in contractile failure and structural cardiac remodelling. We employ
Illumina-based transcriptomics, Nanopore sequencing, and mass spectrometry-based
proteomics on samples from the left ventricle (LV) and right ventricle (RV, RNA only) of the
heart at 1, 7, 21, and 56 days following TAC and Sham surgery. Here, we present TACOMA …
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