User profiles for Yan Daniel Zhao

Yan Daniel Zhao

University of Oklahoma Health Sciences Center
Verified email at ouhsc.edu
Cited by 6421

Dihydrotestosterone synthesis bypasses testosterone to drive castration-resistant prostate cancer

…, L Watumull, YD Zhao… - Proceedings of the …, 2011 - National Acad Sciences
In the majority of cases, advanced prostate cancer responds initially to androgen deprivation
therapy by depletion of gonadal testosterone. The response is usually transient, and …

Nanosomes carrying doxorubicin exhibit potent anticancer activity against human lung cancer cells

…, M Mehta, R Muralidharan, A Chen, YD Zhao… - Scientific reports, 2016 - nature.com
Successful chemotherapeutic intervention for management of lung cancer requires an efficient
drug delivery system. Gold nanoparticles (GNPs) can incorporate various therapeutics; …

Strawberries improve pain and inflammation in obese adults with radiographic evidence of knee osteoarthritis

…, JR Barrett, BT Kurien, N Betts, TJ Lyons, YD Zhao… - Nutrients, 2017 - mdpi.com
Osteoarthritis (OA), the most common form of arthritis, is a significant public health burden in
US adults. Among its many risk factors, obesity is a key player, causing inflammation, pain, …

A non-invasive liquid biopsy screening of urine-derived exosomes for miRNAs as biomarkers in endometrial cancer patients

…, K Moxley, R Ruskin, DN Dhanasekaran, YD Zhao… - The AAPS Journal, 2018 - Springer
Exosomes have great potential to serve as a source of diagnostic and prognostic biomarkers
for endometrial cancer (EC). Urine-derived exosomes from patients with EC and patients …

Folate receptor-targeted nanoparticle delivery of HuR-RNAi suppresses lung cancer cell proliferation and migration

…, K Basalingappa, M Mehta, A Chen, YD Zhao… - Journal of …, 2016 - Springer
Background Human antigen R (HuR) is an RNA binding protein that is overexpressed in many
human cancers, including lung cancer, and has been shown to regulate the expression of …

HuR-targeted small molecule inhibitor exhibits cytotoxicity towards human lung cancer cells

…, R Ahmed, S Roy, L Xu, J Aubé, A Chen, YD Zhao… - Scientific reports, 2017 - nature.com
Human antigen (Hu) R is an RNA-binding protein whose overexpression in human cancer
correlates with aggressive disease, drug resistance, and poor prognosis. HuR inhibition has …

Tumor-targeted Nanoparticle Delivery of HuR siRNA Inhibits Lung Tumor Growth In Vitro and In Vivo By Disrupting the Oncogenic Activity of the RNA-binding Protein …

…, N Amreddy, A Srivastava, A Chen, YD Zhao… - Molecular cancer …, 2017 - AACR
Selective downregulation of the human antigen R (HuR) protein by siRNA may provide a
powerful approach for treating lung cancer. To this end, we investigated the efficacy of …

Exosomes as theranostics for lung cancer

…, N Amreddy, M Razaq, R Towner, YD Zhao… - Advances in cancer …, 2018 - Elsevier
Extensive research in genetics and genomics has revealed that lung cancer is a physiologically
complex and genetically heterogeneous disease. Although molecular targets that can …

Extensive traumatic anterior skull base fractures with cerebrospinal fluid leak: classification and repair techniques using combined vascularized tissue flaps

JB Archer, H Sun, PA Bonney, YD Zhao… - Journal of …, 2016 - thejns.org
OBJECT This article introduces a classification scheme for extensive traumatic anterior skull
base fracture to help stratify surgical treatment options. The authors describe their multilayer …

Preclinical efficacy and involvement of AKT, mTOR, and ERK kinases in the mechanism of sulforaphane against endometrial cancer

…, D Mangiaracina Benbrook, J Garland, Y Daniel Zhao… - Cancers, 2020 - mdpi.com
Sulforaphane exerts anti-cancer activity against multiple cancer types. Our objective was to
evaluate utility of sulforaphane for endometrial cancer therapy. Sulforaphane reduced …