As organelles of the innate immune system, inflammasomes activate caspase-1 and other
inflammatory caspases that cleave gasdermin D (GSDMD). Caspase-1 also cleaves inactive …

Background: Although the prevalence of hypertension (HTN) continues to increase in
developing countries, including China, recent data are lacking. A nationwide survey was …

Mitochondria from many eukaryotic clades take up large amounts of calcium (Ca 2+ ) via an
inner membrane transporter called the uniporter. Transport by the uniporter is membrane …

Poly (ADP-ribose) polymerases (PARPs) are a family of related enzymes that share the ability
to catalyze the transfer of ADP-ribose to target proteins. PARPs play an important role in …

The incidence of neonatal late-onset sepsis (LOS) is inversely related to the degree of
maturity and varies geographically from 0.61% to 14.2% among hospitalised newborns. …

The enterically transmitted hepatitis E virus (HEV) adopts a unique strategy to exit cells by
cloaking its capsid (encoded by the viral ORF2 gene) and circulating in the blood as “quasi-…

Natural killer/T-cell lymphoma (NKTCL) is a malignant proliferation of CD56 + and cytoCD3
+ lymphocytes with aggressive clinical course, which is prevalent in Asian and South …

Lung cancer is the number one cause of cancer-related deaths in the world. Patients treated
with current chemotherapies for non-small-cell lung cancers (NSCLCs) have a survival rate …

INTRODUCTION The nuclear pore complex (NPC) is the molecular conduit in the nuclear
membrane of eukaryotic cells that regulates import and export of biomolecules between the …

Upon activation, brain macrophages, the microglia, release proinflammatory mediators that
play important roles in eliciting neuroinflammatory responses associated with …